公开(公告)号：KR1020080098814A

公开(公告)日：2008-11-12

申请号：KR1020070044150

申请日：2007-05-07

Applicant: 한국과학기술연구원

Inventor： 김동현 ,  유혜현 ,  정혜진 ,  이상규

IPC: A61K36/254 ,  A61P35/00

Abstract: A pharmaceutical composition for aidding anti-cancer drug is provided to suppress CYP3A4 enzyme engaging in a metabolism of the anti-cancer drug by comprising a Jirisan Aralia extract or a lignan based compound separated from the Jirisan Aralia extract as an active ingredient, to enhance a concentration in blood of the anti-cancer drug, to reduce a side effect according to an excessive medication of the anticancer medicine and to exhibit an excellent drug effect. A Jirisan Aralia extract is manufactured by extracting Jirisan Aralia using water, an alcohol or a mixed solvent thereof. The alcohol is a methanol or an ethanol. A lignan based compound is obtained by refining the Jirisan Aralia extract. A pharmaceutical composition for aidding anti-cancer drug is manufactured by comprising the Jirisan Aralia extract or the lignan based compound separated from the Jirisan Aralia extract as an active ingredient.

Abstract translation: 本发明提供了一种药物组合物，其用于抑制抗癌药物的代谢中的CYP3A4酶，其特征在于，含有Jirisan Aralia提取物或从Jirisan Aralia提取物中分离出的木脂素类化合物作为活性成分，以增强抗癌药物的代谢 浓度在抗癌药物的血液中，根据抗癌药物的过量药物减少副作用并显示出优异的药物作用。 Jirisan Aralia提取物通过使用水，酒精或其混合溶剂提取Jirisan Aralia来制造。 醇是甲醇或乙醇。 通过精炼Jirisan Aralia提取物获得木脂素基化合物。 通过包含Jirisan Aralia提取物或从Jirisan Aralia提取物中分离出的木酚素基化合物作为活性成分制造用于启动抗癌药物的药物组合物。

公开(公告)号：KR100829122B1

公开(公告)日：2008-05-13

申请号：KR1020060122415

申请日：2006-12-05

Applicant: 한국과학기술연구원

Inventor： 김동현 ,  유혜현 ,  이민우 ,  김남선

IPC: A61K36/232 ,  A61K31/37 ,  A61P35/00

CPC classification number: A61K31/37 ,  A61K36/232

Abstract: A composition comprising the extract of Angelica gigas Nakai or coumarin based compounds isolated therefrom is provided to inhibit activity of CYP2A6 enzyme as a major enzyme causing lung cancer, so that the composition is useful for prevention of lung cancer. A composition for prevention of lung cancer comprises the extract of Angelica gigas Nakai or coumarin based compounds isolated therefrom represented by the formula(1) or formula(2) wherein R1 is hydroxyl group or C2-C10 alkenylcarbonyloxy group; R2 and R3 are each independently hydrogen, C1-C5 alkyl group or C1-C5 alkyl group having hydroxyl group; R4 is hydrogen, C1-C5 alkoxy or C2-C5 alkenyloxy group; n is 0 or 1; and R5 is linear or branched C2-C10 alkenyl group, wherein the coumarin based compounds include decursin represented by the formula(3), decursinol angelate represented by the formula(5), 7-dimethyl suberosine represented by the formula(6) or isoimperatorin represented by the formula(7).

Abstract translation: 提供了包含从其中分离出的当归提取物或基于香豆素的化合物的组合物以抑制CYP2A6酶作为引起肺癌的主要酶的活性，使得该组合物可用于预防肺癌。 用于预防肺癌的组合物包括由式（1）或式（2）表示的其中R 1为羟基或C 2 -C 10烯基羰基氧基的分离自其的分离的当归粉末或香豆素基化合物的提取物; R2和R3各自独立地为氢，C1-C5烷基或具有羟基的C1-C5烷基; R4是氢，C1-C5烷氧基或C2-C5烯氧基; n为0或1; 其中所述香豆素类化合物包括由式（3）表示的前胡素，由式（5）表示的当归酸前胡酯，由式（6）表示的7-二甲基异亮氨酸或异精氨酸 由式（7）表示。