公开(公告)号：KR1020080098814A

公开(公告)日：2008-11-12

申请号：KR1020070044150

申请日：2007-05-07

Applicant: 한국과학기술연구원

Inventor： 김동현 ,  유혜현 ,  정혜진 ,  이상규

IPC: A61K36/254 ,  A61P35/00

Abstract: A pharmaceutical composition for aidding anti-cancer drug is provided to suppress CYP3A4 enzyme engaging in a metabolism of the anti-cancer drug by comprising a Jirisan Aralia extract or a lignan based compound separated from the Jirisan Aralia extract as an active ingredient, to enhance a concentration in blood of the anti-cancer drug, to reduce a side effect according to an excessive medication of the anticancer medicine and to exhibit an excellent drug effect. A Jirisan Aralia extract is manufactured by extracting Jirisan Aralia using water, an alcohol or a mixed solvent thereof. The alcohol is a methanol or an ethanol. A lignan based compound is obtained by refining the Jirisan Aralia extract. A pharmaceutical composition for aidding anti-cancer drug is manufactured by comprising the Jirisan Aralia extract or the lignan based compound separated from the Jirisan Aralia extract as an active ingredient.

Abstract translation: 本发明提供了一种药物组合物，其用于抑制抗癌药物的代谢中的CYP3A4酶，其特征在于，含有Jirisan Aralia提取物或从Jirisan Aralia提取物中分离出的木脂素类化合物作为活性成分，以增强抗癌药物的代谢 浓度在抗癌药物的血液中，根据抗癌药物的过量药物减少副作用并显示出优异的药物作用。 Jirisan Aralia提取物通过使用水，酒精或其混合溶剂提取Jirisan Aralia来制造。 醇是甲醇或乙醇。 通过精炼Jirisan Aralia提取物获得木脂素基化合物。 通过包含Jirisan Aralia提取物或从Jirisan Aralia提取物中分离出的木酚素基化合物作为活性成分制造用于启动抗癌药物的药物组合物。

公开(公告)号：KR100027036B1

公开(公告)日：1989-01-12

申请号：KR1019860002080

申请日：1986-03-20

Applicant: 한국과학기술연구원 ,  대한민국(농촌진흥청장)

Inventor： 민태익 ,  유익동 ,  김창진 ,  김성훈 ,  이윤 ,  김석동 ,  이상규

IPC: C12N1/00

公开(公告)号：KR1019880002313B1

公开(公告)日：1988-10-22

申请号：KR1019860002080

申请日：1986-03-20

Applicant: 한국과학기술연구원 ,  대한민국(농촌진흥청장)

Inventor： 민태익 ,  유익동 ,  김창진 ,  김성훈 ,  이윤 ,  김석동 ,  이상규

IPC: C12N1/00

Abstract: Root-nodle bacteria inocula for leguminous plants were prepd. Thus, Rhizobium japonicum KLTL 8182p was cultured on the medium contg. 10 mannitol. 1.0 yeast extract, 0.2 MgSO4, 0.2 NaCl, and 0.2g K2HPO4 per liter of water for 3 days at 28↿C. 100 peat, or 100 lignite, or 100 zelite, or 100 g leaf mold was pulverized to > 100 mesh particles, autoclaved for 3 hr at 121↿C,and mixed with the above cultures (40ml), 0.5 g Me, and 5 g B. The mixt. was packed into a polyethylenevinyl bag, sealed, and incubated for 2 weeks at room temp. to provide inocula availible for 1000m2 soils.

Abstract translation: 豆科植物根瘤细菌接种物 因此，日本根瘤菌KLTL 8182p在培养基上培养。 10甘露醇。 1.0酵母提取物，0.2 MgSO 4，0.2 NaCl和0.2g K 2 HPO 4 /升水，在28℃下3天。 将100个泥炭或100个褐煤或100个zelite或100g叶霉粉碎至> 100目的颗粒，在121℃下高压灭菌3小时，并与上述培养物（40ml），0.5g Me和5g 混合 装入聚乙烯乙烯基袋中，密封，并在室温下孵育2周。 提供可用于1000m2土壤的接种物。