公开(公告)号：KR1020120078687A

公开(公告)日：2012-07-10

申请号：KR1020120056983

申请日：2012-05-29

Applicant: 한국과학기술연구원

Inventor： 오창현 ,  조정혁

IPC: C12P35/00 ,  A61K31/545

CPC classification number: C12P35/06 ,  A61K31/545 ,  C07B2200/13 ,  C07D501/16 ,  C12N9/84 ,  C12Y305/01011

Abstract: PURPOSE: A method for preparing a cephalosporin-based antibiotic intermediate is provided to industrially synthesize crystalline hydrate of the intermediate and to develop the antibiotics. CONSTITUTION: A method for preparing a cephalosporin-based antibiotic intermediate of chemical formula 1 comprises: a step of adding cresol and phenol to a compound of chemical formula 2 and stirring for deprotecting protection groups of a carboxyl group; a step of adding syntha CLEC-PA(cross-linked enzyme crystal-penicillin g amidase/acylase) while adjusting pH concentration using alkaline; a step of adjusting pH concentration using inorganic acid. The alkaline is hydrocarbon alkali metal, alkali hydroxide metal, ammonia solution, or trialkyl amine. The hydrocarbon alkali metal is sodium carbonate or potassium carbonate.

Abstract translation: 目的：提供一种制备头孢菌素类抗生素中间体的方法，以工业合成中间体的结晶水合物并开发抗生素。 构成：一种制备化学式1的头孢菌素类抗生素中间体的方法，包括：向化学式2的化合物中加入甲酚和苯酚并搅拌使羧基保护基团脱保护的步骤; 在使用碱性调节pH浓度的同时加入合成CLEC-PA（交联酶结晶 - 青霉素g酰胺酶/酰基转移酶）的步骤; 使用无机酸调节pH浓度的步骤。 碱性为烃类碱金属，碱金属氢氧化物，氨溶液或三烷基胺。 烃类碱金属是碳酸钠或碳酸钾。

公开(公告)号：KR1020120040980A

公开(公告)日：2012-04-30

申请号：KR1020100102522

申请日：2010-10-20

Applicant: 한국과학기술연구원

Inventor： 오창현 ,  정명호 ,  엘가말모하메드 ,  유경호 ,  심태보 ,  최원경 ,  조정혁

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: PURPOSE: A pyrrolo[3,2-c]pyridine derivative and a pharmaceutical composition containing the same are provided to ensure anti-proliferatioin activity of melanoma and to prevent or treat melanoma. CONSTITUTION: A pyrrolo[3,2-c]pyridine derivative is denoted by chemical formula I. A method for preparing the pyrrolo[3,2-c]pyridine derivative of chemical formula I' or pharmaceutically acceptable salt thereof comprises: a step of reacting 4-chloro-1-pyrrolo[2,3-b]pyridine of chemical formula II with nitroaniline to prepare a compound of chemical formula III; a step of reacting a compound of chemical formula III with benzoyl chloride to prepare a compound of chemical formula IV; a step of reducing the compound of chemical formula IV to prepare a compound of chemical formula V; and a step of reacting the compound of chemical formula V with a compound of chemical formula VI or formula VII.

Abstract translation: 目的：提供吡咯并[3,2-c]吡啶衍生物和含有它们的药物组合物，以确保黑色素瘤的抗增殖活性并预防或治疗黑素瘤。 构成：化学式I表示吡咯并[3,2-c]吡啶衍生物。制备化学式I'吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐的方法包括： 使化学式II的4-氯-1-吡咯并[2,3-b]吡啶与硝基苯胺反应制备化学式Ⅲ化合物; 使化学式III的化合物与苯甲酰氯反应以制备化学式IV的化合物的步骤; 降低化学式IV化合物以制备化学式V的化合物的步骤; 以及使化学式V的化合物与化学式VI或式VII的化合物反应的步骤。

公开(公告)号：KR1020100031837A

公开(公告)日：2010-03-25

申请号：KR1020080090659

申请日：2008-09-16

Applicant: 한국과학기술연구원

Inventor： 오창현 ,  조정혁

IPC: C07D413/10 ,  C07D413/02

CPC classification number: C07D413/10

Abstract: PURPOSE: A novel oxazolidinone derivative having dilfuorophenyl derivative is provided to ensure antibacterial activity to Vancomycin-Resistant Enterococcus including Haemophilus influenza and Coagulase negative staphylococci. CONSTITUTION: A novel oxazolidinone derivative with a dilfuorophenyl derivative is denoted by chemical formula 1. A method for preparing the oxazolidinone derivative comprises: a step of reacting a compound of chemical formula 2 with trifluorenitrobenzene of chemical formula 3 to prepare a compound of chemical formula 4; a step of reducing the compound of chemical formula 4 to prepare a compound of chemical formula 5; a step of introducing carbobenzyloxy(CBZ) group to amine group of the compound of chemical formula 5 to obtain a compound of chemical formula 6; a step of adding n-butyl lithium and (R)-glycidyl butyrate to the compound of chemical formula 6 to prepare a compound of chemical formula 7; a step of performing methylation of hydroxyl group of the compound of chemical formula 7 to obtain a compound of chemical formula 8; a step of reacting the compound of chemical formula 8 with sodium azide to obtain a compound of chemical formula 9; a step of performing reduction and acetylation of the compound of chemical formula 9 to obtain a compound of chemical formula 10; a step of deprotecting the compound of chemical formula 10 to obtain a compound of chemical formula 11; and a step of reducing the compound of chemical formula 11 to obtain a compound of chemical formula 1a.

Abstract translation: 目的：提供一种具有二氟代苯基衍生物的新型恶唑烷酮衍生物，以确保对耐万古霉素肠球菌的抗菌活性，包括流感嗜血杆菌和凝固酶阴性葡萄球菌。 构成：具有二氟苯基衍生物的新型恶唑烷酮衍生物由化学式1表示。制备恶唑烷酮衍生物的方法包括：使化学式2的化合物与化学式3的三氟硝基苯反应以制备化学式4的化合物 ; 还原化学式4的化合物以制备化学式5的化合物的步骤; 将苄氧羰基（CBZ）基团引入到化学式5的化合物的胺基上以获得化学式6的化合物的步骤; 向化学式6化合物中加入正丁基锂和（R） - 缩水甘油基丁酸酯以制备化学式7的化合物的步骤; 进行化学式7的化合物的羟基的甲基化的步骤，得到化学式8的化合物; 使化学式8的化合物与叠氮化钠反应的步骤，得到化学式9的化合物; 进行化学式9的化合物的还原和乙酰化以获得化学式10的化合物的步骤; 使化学式10的化合物脱保护以获得化学式11的化合物的步骤; 以及还原化学式11化合物以获得化学式1a化合物的步骤。

公开(公告)号：KR1020090021644A

公开(公告)日：2009-03-04

申请号：KR1020070086301

申请日：2007-08-27

Applicant: 한국과학기술연구원

Inventor： 조정혁 ,  김성규

IPC: A61K36/62 ,  A61K36/8994 ,  A61K36/54 ,  A61P3/04

CPC classification number: A61K36/00 ,  A23V2200/332 ,  A61K9/0053 ,  A61K36/484 ,  A61K36/54 ,  A61K36/62 ,  A61K36/734 ,  A61K36/899 ,  A61K2236/33 ,  Y10S514/909

Abstract: A composition for obesity suppression and treatment including leaves extract of nelumbo nucifera is provided to facilitate provision of raw materials for a herbal medicine with low cost and ensure an effect of suppressing absorption of carbohydrate and lipid. A composition for obesity suppression and treatment including leaves extract of nelumbo nucifera comprises 140-180wt% of leaves extract of nelumbo nucifera, 30-50wt% of Cinnamomi Ramulus, 20-40wt% of ginger, 80-100wt% of Coicis semen, 30-50wt% of Polygoni Multiflori Radix, 20-40wt% of Phaseolus angularis Wight, 20-30wt% of Saliconia herbacea, 15-25wt% of dried chestnut shell, 10-30wt% of cottonseed, 30-50wt% of Raphani Semen, 30-40wt% of Atractyodis Rhizoma, 15-25wt% of Atractylodes macrocephala, 1-7wt% of Zingiberis Rhizoma, 30-40wt% of Crataegi Fructus, and 15-25wt% of extract obtained by extracting licorice using alcohol.

Abstract translation: 本发明提供一种用于肥胖抑制和治疗的组合物，包括非特异性结肠炎叶片提取物，以便于低成本地提供中草药原料，并确保抑制碳水化合物和脂质吸收的作用。 用于肥胖抑制和治疗的组合物，包括Nelumbo nucifera的叶提取物，其包含140-180wt％的叶片提取物，Nelumbo nucifera的叶提取物，30-50wt％的Cinnamomi Ramulus，20-40wt％的姜，80-100wt％的Coicis精液， 50％重量百里香，20-40％（重量），20-30％（重）百里香，15-25％（重）干燥栗壳，10-30％（重）棉籽，30-50％（重量） （Atractyodis Rhizoma），重量百分比（Abractyodis Rhizoma）的重量百分比为40wt％，白术百分之十五至25wt％，刺槐根茎占1-7wt％，禾谷镰刀菌30-40wt％，醇提取甘草提取物为15-25wt％。

公开(公告)号：KR1020070105679A

公开(公告)日：2007-10-31

申请号：KR1020060038179

申请日：2006-04-27

Applicant: 한국과학기술연구원

Inventor： 조정혁 ,  안덕균 ,  김영옥 ,  이승채

IPC: A61K36/69 ,  A61K36/882 ,  A61P25/28

CPC classification number: A61K36/69 ,  A23V2200/322 ,  A61K36/258 ,  A61K36/882 ,  A61K2236/33

Abstract: A composition for improving memory is provided to prevent and treat various diseases caused by severe decline of recognition ability associated with both cholinergic and non-cholinergic nerve system without side effects to human body. A composition for improving memory comprises extracts of the mixture containing 10-30 wt.% of Polygala tenuifolia Willdenow, 10-30 wt.% of Acorus gramineus, 5-10 wt.% of Panax ginseng, 5-20 wt.% of Angelica gigas, 10-30 wt.% of Ginkgo biloba leaf, 10-30 wt.% of Schisandra chinensis and 10-30 wt.% of Cnidium officinale as effective ingredients, and further comprises vitamins, minerals and blood circulation-improving agents including gamma linoleic acid, EPA(eicosapentaenoic acid) and tocopherol as subsidiary ingredients, wherein the mixture extracts are prepared by extracting the mixture with alcohol or hot water.

Abstract translation: 提供一种改善记忆的组合物，用于预防和治疗由胆碱能和非胆碱能神经系统相关识别能力严重下降引起的各种疾病，对人体无副作用。 用于改善记忆的组合物包括含有10-30重量％的Polygala tenuifolia Willdenow，10-30重量％的Acorus gramineus，5-10重量％的人参，5-20重量％的当归的混合物的提取物 小檗，10-30重量％的银杏叶，10-30重量％的五味子和10-30重量％的芫荽作为有效成分，还包括维生素，矿物质和血液循环改善剂，包括γ 亚油酸，EPA（二十碳五烯酸）和生育酚作为辅助成分，其中混合物提取物通过用醇或热水萃取混合物来制备。

公开(公告)号：KR100761660B1

公开(公告)日：2007-10-04

申请号：KR1020060021965

申请日：2006-03-08

Applicant: 한국과학기술연구원

Inventor： 조정혁

IPC: A61K8/97 ,  A61Q7/00

Abstract: 본 발명은 하수오, 측백엽, 골쇄보, 상백피, 백작약, 당귀, 구기자, 황정, 숙지황, 다시마, 복분자 및 대추로 이루어진 혼합 추출물을 함유하는 조성물에 관한 것으로서, 이러한 조성물은 인체에 안전하며, 모발 성장을 촉진시키는 효과가 뛰어나다.
하수오, 측백엽, 모발 성장

公开(公告)号：KR1020050001254A

公开(公告)日：2005-01-06

申请号：KR1020030042835

申请日：2003-06-27

Applicant: 주식회사 엔에스케이텍 ,  한국과학기술연구원

Inventor： 윤범덕 ,  홍종진 ,  유가이비탈리 ,  조정혁

IPC: A61K36/066 ,  A61P3/10

CPC classification number: A61K36/068 ,  A23L33/105 ,  A61K9/0053 ,  A61K33/08 ,  A61K36/42 ,  A61K2300/00

Abstract: PURPOSE: Provided is a composition which has excellent hypoglycemic effect by comprising Paecilomyces japonica, Momordica charantia and magnesium. Therefore, the composition is used to effectively control high blood sugar level caused by diabetes. CONSTITUTION: The composition having excellent hypoglycemic effect is characterized by comprising 40-75 wt.% of Paecilomyces japonica, 20-50 wt.% of Momordica charantia and 5-10 wt.% of magnesium. The composition is orally administered to control high blood sugar level effectively.

Abstract translation: 目的：提供一种具有优异的降血糖作用的组合物，其包括j comprising ica，苦瓜和镁。 因此，该组合物用于有效控制由糖尿病引起的高血糖水平。 构成：具有优异的降血糖效果的组合物的特征在于包含40-75重量％的拟青藓，20-50重量％的苦瓜和5-10重量％的镁。 口服组合物以有效控制高血糖水平。

公开(公告)号：KR100378117B1

公开(公告)日：2003-03-29

申请号：KR1020000001329

申请日：2000-01-12

Applicant: 한국과학기술연구원

Inventor： 조정혁 ,  오창현 ,  오창석 ,  이기수

IPC: A01N29/00

Abstract: PURPOSE: A removing method for noxious tide using chlorine dioxide is provided, which can remove noxious tide effectively without secondary pollution by spreading chlorine dioxide solution on a sea area with red tide or green tide. CONSTITUTION: The chlorine dioxide is produced by reacting sodium chlorite with chlorine; 2NaClO2 + Cl2 → 2ClO2 + 2NaCl, which exists as a yellow-green gas at normal temperature, is used in an aqueous solution by dissolving in water to make the concentration at a ratio of 0.1-1ppm, and removes noxious tide with microorganisms(such as Cochlodinium, Chaetoceros, Mesodinium, Gymnodinium, and Gyrodinium) as well as toxic substances produced by them due to strong oxidizing power thereof. But a halogenide is not produced as a by-product, and the chlorine dioxide is easily resolved into oxygen molecule and chlorine ion by sunlight.

Abstract translation: 目的：提供一种利用二氧化氯的有毒潮汐的去除方法，该方法通过在赤潮或绿潮的海域散布二氧化氯溶液来有效去除有害潮汐而无二次污染。 组成：二氧化氯由亚氯酸钠与氯反应产生; 2NaClO 2 + Cl 2＆amp; 在常温下以黄绿色气体形式存在的2ClO 2 + 2NaCl在水溶液中使用，通过溶解在水中使浓度达到0.1-1ppm，并用微生物（如Cochlodinium，Chaetoceros ，中子，（Mesodinium），Gymnodinium和Gyrodinium）以及由于其强氧化能力而产生的有毒物质。 但是，卤化物不作为副产物产生，并且二氧化氯通过日光很容易分解成氧分子和氯离子。

公开(公告)号：KR100355344B1

公开(公告)日：2002-10-12

申请号：KR1020000001496

申请日：2000-01-13

Applicant: 한국과학기술연구원

Inventor： 조정혁 ,  오창현 ,  오창석

IPC: C02F9/00 ,  C02F1/52 ,  C02F1/38

Abstract: 본 발명은 이동형 정수장치에 관한 것으로서, 특히, 정수에 필요한 장치를 효율적으로 조합함으로써 소형으로 축합 설치하여 이동성을 가지는 이동형 정수장치에 관한 것이다. 본 발명은 원수에 소독제를 투입하기 위한 제 1 소독제공급부와; 상기 소독제가 투입된 물에 응집제를 투입하기 위한 응집제공급부와; 상기 응집제가 투입된 물에 포함된 이물질을 원심분리하기 위한 원심분리기와; 상기 원심분리기를 거친 물에 포함된 이물질을 침전시키기 위한 침전장치와; 상기 침전장치를 거친 물을 여과하기 위한 여과장치와; 상기 여과장치를 거친 물에 소독제를 투입하기 위한 제 2 소독제공급부로 이루어지는 이동성을 갖는 정수장치를 제공한다.

公开(公告)号：KR1020020059042A

公开(公告)日：2002-07-12

申请号：KR1020000087302

申请日：2000-12-30

Applicant: 한국과학기술연구원

Inventor： 오창석 ,  조정혁 ,  오창현 ,  이기수

IPC: C07F9/38

CPC classification number: C07F9/40

Abstract: PURPOSE: Provided is a manufacturing method for dialkyl(4-hydroxy-3,5-di(t-butyl)benzyl)phosphonate(DAP) in high yield , thereby mass-producing DAP without generating carcinogens not by using a strong base. CONSTITUTION: Dialkyl(4-hydroxy-3,5-di(t-butyl)benzyl)phosphonate is manufactured by reacting N, N-dialkyl-(4-hydroxy-3,5-di(t-butyl)benzyl)amine or its salt with dialkyl phosphate or trialkyl phosphate in the presence of an alkylating agent, at 60-120 deg.C.

Abstract translation: 目的：提供高收率的（4-羟基-3,5-二（叔丁基）苄基）膦酸二烷基酯（DAP）的制造方法，从而大量生产DAP而不产生致癌物质而不是使用强碱。 构成：通过使N，N-二烷基 - （4-羟基-3,5-二（叔丁基）苄基）胺反应制得二（2,4-羟基-3,5-二（叔丁基）苄基） 其盐与磷酸二烷基酯或磷酸三烷基酯在烷基化剂存在下，在60-120℃。