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公开(公告)号：DE69633768D1
公开(公告)日：2004-12-09
申请号：DE69633768
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I
IPC: A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B1/00 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Systems and methods recommend storage parameters for a prescribed number of platelets in a prescribed gas permeable container and in association with a specified storage medium. The systems and methods receiving as input selected storage criteria information. The systems and methods generate as output, based upon the selected storage criteria information received, recommended storage parameters comprising a recommended number of selected storage containers (PltBAG) to be used and a recommended volume of storage medium (PltMED) to be used.
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公开(公告)号：DE69631282T2
公开(公告)日：2004-11-25
申请号：DE69631282
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I
IPC: A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D17/038 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Blood collection systems and methods minimize citrate toxicity in donors. The systems and methods convey whole blood at a prescribed rate Qb into a separation device for separation into red blood cells and a plasma constituent. The systems and methods add anticoagulant including citrate to the whole blood. The systems and methods control Qb (in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQBCIR, where: where: CIR is a selected nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), AC is a selected anticoagulant ratio, Wgt is the donor's weight (in kg or equivalent), and CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent).
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公开(公告)号：DE69626832T2
公开(公告)日：2003-12-04
申请号：DE69626832
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I , MIN KYUNGYOON
IPC: A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: A blood separation system for separating mono nuclear cells from whole blood is described. The system comprises a chamber (12) that is rotatable about a rotational axis (28). The chamber comprises first and second spaced apart walls (24, 26) that form a separation zone having a high-G side and a low-G side which is located closer to the rotational axis than the high-G side. The chamber also includes an inlet region (74) where whole blood enters the separation zone for separation into red blood cells (96), a plasma constituent carrying platelets (98), and an interface (58) carrying mono nuclear cells between the red blood cells and the plasma constituent. A plasma constituent collection region (76) is also provided in the chamber where the plasma constituent is collected for removal from the chamber. An outlet path (46, 206) communicates with the plasma constituent collection region (76) and provides for removal of the interface (58) from the chamber. The system is operated under the control of a controller (134) that is operable in first and second modes. In the first mode, whole blood is conveyed into the inlet region while red blood cells and the plasma constituent are removed from the chamber and while the interface (58) is maintained at a set location within the chamber. In the second mode, the controller operates to move the interface from the set location for removal from the chamber via the outlet path. Finally, the system is equipped with a sensing element (226) for detecting mono nuclear cells in the interface in the outlet path. A method of separating mono nuclear cells from whole blood is also described.
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公开(公告)号：DE69431653T2
公开(公告)日：2003-07-24
申请号：DE69431653
申请日：1994-03-17
Applicant: BAXTER INT
Inventor： BROWN I , WILLIAMSON P , DIPERNA PAUL
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Patent Agency Ranking
公开(公告)号：DE69633768T2
公开(公告)日：2005-10-27
申请号：DE69633768
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I
IPC: A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B1/00 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Systems and methods recommend storage parameters for a prescribed number of platelets in a prescribed gas permeable container and in association with a specified storage medium. The systems and methods receiving as input selected storage criteria information. The systems and methods generate as output, based upon the selected storage criteria information received, recommended storage parameters comprising a recommended number of selected storage containers (PltBAG) to be used and a recommended volume of storage medium (PltMED) to be used.
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公开(公告)号：DE69330221T2
公开(公告)日：2002-04-18
申请号：DE69330221
申请日：1993-01-08
Applicant: BAXTER INT
Inventor： OFSTHUN J , HENDERSON W , BROWN I , PAULEY G
IPC: A61M1/18 , B01D61/14 , B01D61/18 , B01D61/24 , B01D63/02 , B01D69/02 , B01D69/08 , B01D71/68 , C12M1/12 , C12M3/06 , B01D63/08
Abstract: The invention employs dual-skinned membranes useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have sieving coefficient characteristics different for flow of liquids in one direction from that in the opposite direction. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties. Improved bioreactors are formed by using bundles of hollow fiber as a growth vessel having rectifying properties.
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