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公开(公告)号：WO2015017348A3
公开(公告)日：2015-11-05
申请号：PCT/US2014048484
申请日：2014-07-28
Applicant: BIO RAD LABORATORIES
Inventor： SWIHART STEVE , THRUSH EVAN , PEREZ EVELIO , MCDONALD KEVIN
IPC: G02B26/08
CPC classification number: G02B15/14
Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.
Abstract translation: 用于在凝胶或其它基底中观察，成像和分析化学发光或生物发光样品的成像组件，其中具有主要或固定透镜或聚焦透镜的可调节照相机和透镜模块移动以通过移动来改变视场 相机和镜头模块的焦平面。 成像组件还可以包括用于弯曲或折叠相机和透镜模块之间的光路的反射镜和具有样品的目标区域，其中反射镜可以在与相机和透镜模块相同的垂直方向上移动。 此外，相机和透镜模块可以被配置为相对于成像目标区域的位置在对角线方向上更多地移动。 成像组件还可以具有适于根据相机和透镜模块的运动进行调节的管道系统。
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Patent Agency Ranking
公开(公告)号：CA2763369A1
公开(公告)日：2010-12-09
申请号：CA2763369
申请日：2010-06-01
Applicant: BIO RAD LABORATORIES
Inventor： KOTCHOU KEITH , SCHULTZ CHRISTOF , MCDONALD KEVIN , BHATT NEERAJ
IPC: G06K9/00
Abstract: Methods, apparatuses, and systems for imaging biological/chemical samples are provided. A calibrated imaging system can allow a user to obtain an optimal focus setting (position) for any effective distance (e.g. a zoom setting). The optimal focus can be determined from a functional approximation that defines a relationship between effective distance and focus setting. A user can input a size, and an imaging system can determine the appropriate effective distance and focus. An imaging system can also determine a size based on any effective distance. A flat-field correction can also be determined for any effective distance or size.
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公开(公告)号：EP2825867A4
公开(公告)日：2016-02-17
申请号：EP13761630
申请日：2013-03-14
Applicant: BIO RAD LABORATORIES
Inventor： KOTCHOU KEITH , MCDONALD KEVIN , LEE JAMES
IPC: G01N21/76
CPC classification number: G01N21/76
Abstract: An image system for detecting chemiluminescence in a sample uses a highly binned, short exposure initial image to calculate the exposure time for a final image of the sample. After calculation of the exposure time, at least two final images are taken, with saturated pixels removed and replaced in a first image with corresponding unsaturated pixels from a second image. The corresponding pixels are adjusted to reflect the different intensity levels between the first and second images, and the first image becomes the final image reflecting the detected chemiluminescence.
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公开(公告)号：EP2987019A4
公开(公告)日：2016-11-09
申请号：EP14832584
申请日：2014-07-28
Applicant: BIO RAD LABORATORIES
Inventor： SWIHART STEVE , THRUSH EVAN , PEREZ EVELIO , MCDONALD KEVIN
CPC classification number: G02B15/14
Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.
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公开(公告)号：EP2841927A4
公开(公告)日：2015-12-30
申请号：EP13780565
申请日：2013-04-25
Applicant: BIO RAD LABORATORIES
Inventor： FREEBY STEVE , LIU NING , MCDONALD KEVIN , PAULUS ARAN , POSCH ANTON
CPC classification number: G01N33/53 , G01N33/6827 , G06F19/10 , G06T7/0012 , G06T11/60 , G06T2207/30004
Abstract: Disclosed herein are methods of protein quantification and normalization using haloalkylated tryptophan fluorescence. Complex protein samples, i.e., samples that each contain 1,000 or more distinct proteins, from diverse sources that do not have common protein profiles are treated with a halo-substituted organic compound (i.e. haloalkane) that reacts with tryptophan residues to form fluorescent products. Irradiation of the samples with ultraviolet light and the detection and quantification of the resultant fluorescent emissions from all proteins in each sample are then used to obtain comparative values for total protein content among the various samples. The values thus obtained are found to be valid indications of comparative total protein content, despite the fact that the tryptophan levels vary widely among the various proteins in any single sample and the samples, due to the diversity of their origins, tend to differ among themselves in the identities and relative amounts of the proteins that they contain. Protein samples are also normalized to correct for differences in sample dilution, sample loading, and protein transfer inconsistencies, by using stain-free detection of total protein in each of the samples, or detection of subsamples within each sample.
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公开(公告)号：EP2438554A4
公开(公告)日：2015-07-29
申请号：EP10783936
申请日：2010-06-01
Applicant: BIO RAD LABORATORIES
Inventor： KOTCHOU KEITH , SCHULTZ CHRISTOF , MCDONALD KEVIN , BHATT NEERAJ
IPC: G06T7/00
CPC classification number: G06T7/0018 , G06T7/80 , G06T2207/30024 , G06T2207/30208
Abstract: Methods, apparatuses, and systems for imaging biological/chemical samples are provided. A calibrated imaging system can allow a user to obtain an optimal focus setting (position) for any effective distance (e.g. a zoom setting). The optimal focus can be determined from a functional approximation that defines a relationship between effective distance and focus setting. A user can input a size, and an imaging system can determine the appropriate effective distance and focus. An imaging system can also determine a size based on any effective distance. A flat-field correction can also be determined for any effective distance or size.
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