公开(公告)号：AU2002344839B2

公开(公告)日：2006-05-11

申请号：AU2002344839

申请日：2002-06-19

Applicant: BIO RAD LABORATORIES

Inventor： NAGHIEH HAMID R ,  GINGRICH JEFFREY ,  KOTCHOU KEITH ,  BHATT NEERAJ

IPC: G01N21/64 ,  G01N27/26 ,  G01N21/27 ,  G01N27/447

Abstract: The optical imaging of two-dimensional solute zone arrays in electrophoresis gels is corrected for nonuniformities in the optical system such as those arising from the light source or from light dispersion underneath the gel. The correction is achieved by the use of a reference plate that responds to a light source uniformly along its length and width by being either uniformly light absorptive or uniformly light transmissive, or by emitting light upon excitation. Thus, any nonuniformities or deviations in the image of the reference plate arise only from nonuniformities or deviations within the optical system. Analogous corrections are made in other two-dimensional assay images, such as microarrays and microtiter plates.

公开(公告)号：DE07865871T1

公开(公告)日：2010-01-07

申请号：DE07865871

申请日：2007-12-19

Applicant: BIO RAD LABORATORIES

Inventor： MEHTA SURESH N ,  BHATT NEERAJ ,  MCDONALD KEVIN A

IPC: G01N30/00

Abstract: Images of two-dimensional chromatograms or other sample arrays are formed on a scanning instrument that utilizes a line of illumination light that sweeps the length of the array either by moving across the array or by the array moving relative to the light, in either case scanning the entire two-dimensional array with a unidirectional pass of the moving component. The use of a CCD equipped with time delay integration allows the instrument to form an enhanced image.

公开(公告)号：CA2672635A1

公开(公告)日：2008-07-03

申请号：CA2672635

申请日：2007-12-19

Applicant: BIO RAD LABORATORIES

Inventor： MEHTA SURESH N ,  BHATT NEERAJ ,  MCDONALD KEVIN A

IPC: G01N30/00

Abstract: Images of two-dimensional chromatograms or other sample arrays are formed on a scanning instrument that utilizes a line of illumination light that sw eeps the length of the array either by moving across the array or by the arr ay moving relative to the light, in either case scanning the entire two-dime nsional array with a unidirectional pass of the moving component. The use of a CCD equipped with time delay integration allows the instrument to form an enhanced image.

公开(公告)号：CA2672635C

公开(公告)日：2016-02-09

申请号：CA2672635

申请日：2007-12-19

Applicant: BIO RAD LABORATORIES

Inventor： MEHTA SURESH N ,  BHATT NEERAJ ,  MCDONALD KEVIN A

IPC: G01N21/84 ,  G01N21/64 ,  G01N21/76

Abstract: Images of two-dimensional chromatograms or other sample arrays are formed on a scanning instrument that utilizes a line of illumination light that sweeps the length of the array either by moving across the array or by the array moving relative to the light, in either case scanning the entire two-dimensional array with a unidirectional pass of the moving component. The use of a CCD equipped with time delay integration allows the instrument to form an enhanced image.

公开(公告)号：CA2763369A1

公开(公告)日：2010-12-09

申请号：CA2763369

申请日：2010-06-01

Applicant: BIO RAD LABORATORIES

Inventor： KOTCHOU KEITH ,  SCHULTZ CHRISTOF ,  MCDONALD KEVIN ,  BHATT NEERAJ

IPC: G06K9/00

Abstract: Methods, apparatuses, and systems for imaging biological/chemical samples are provided. A calibrated imaging system can allow a user to obtain an optimal focus setting (position) for any effective distance (e.g. a zoom setting). The optimal focus can be determined from a functional approximation that defines a relationship between effective distance and focus setting. A user can input a size, and an imaging system can determine the appropriate effective distance and focus. An imaging system can also determine a size based on any effective distance. A flat-field correction can also be determined for any effective distance or size.

公开(公告)号：CA2450385A1

公开(公告)日：2003-01-09

申请号：CA2450385

申请日：2002-06-19

Applicant: BIO RAD LABORATORIES

Inventor： NAGHIEH HAMID R ,  KOTCHOU KEITH ,  BHATT NEERAJ ,  GINGRICH JEFFREY

IPC: G01N21/64 ,  G01N21/27 ,  G01N27/447 ,  G01N27/26

Abstract: The optical imaging of two-dimensional solute zone arrays in electrophoresis gels is corrected for nonuniformities in the optical system such as those arising from the light source or from light dispersion underneath the gel. T he correction is achieved by the use of a reference plate that responds to a light source uniformly along its length and width by being either uniformly light absorptive or uniformly light transmissive, or by emitting light upon excitation. Thus, any nonuniformities or deviations in the image of the reference plate arise only from nonuniformities or deviations within the optical system. Analogous corrections are made in other two-dimensional assa y images, such as microarrays and microtiter plates.

公开(公告)号：WO2014172269A3

公开(公告)日：2015-10-29

申请号：PCT/US2014033978

申请日：2014-04-14

Applicant: BIO RAD LABORATORIES

Inventor： MCKEE CLAYTON T ,  STRONG WILLIAM ,  BHATT NEERAJ

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6456

Abstract: Systems and methods for simultaneously exciting a fluorescently labeled specimen and capturing fluorescent light emitted therefrom using a smartphone, tablet, or similar mobile computing device, are disclosed herein. The system includes a light-emitting diode ("LED") light source coupled with the smartphone to excite the specimen and an imaging device coupled with the smartphone to capture fluorescent light emitted from the specimen. The system further includes a hood adapted to be coupled with the smartphone that has an excitation filter configured to produce a first wavelength of electromagnetic radiation to strike the specimen when light from the LED light source passes through it and an emission filter configured to receive the light emitted from the specimen and to produce a second wavelength of electromagnetic radiation to be captured by the imaging device.

Abstract translation: 本文公开了同时激发荧光标记的样本并使用智能电话，平板电脑或类似的移动计算设备捕获从其发射的荧光的系统和方法。 该系统包括与智能手机耦合以激发样本的发光二极管（“LED”）光源和与智能手机耦合的成像装置以捕获从样品发射的荧光。 该系统还包括适于与智能电话耦合的罩，其具有激励滤波器，该激励滤波器被配置为产生第一波长的电磁辐射以在来自LED光源的光穿过其时撞击样本;以及发射滤波器，被配置为接收光 从样品发射并产生将被成像装置捕获的第二波长的电磁辐射。

公开(公告)号：CA2750112A1

公开(公告)日：2010-08-05

申请号：CA2750112

申请日：2010-01-27

Applicant: BIO RAD LABORATORIES

Inventor： WALDBESER DAVID E ,  BHATT NEERAJ ,  MCDONALD KEVIN A

IPC: H05B35/00

Abstract: An adaptor is designed as an accessory to an ultraviolet transilluminator for the excitation of fluorescent molecules or labels in a planar array of biochemical samples such as a two-dimensional electrophoresis gel to enable the emissions resulting from the excitation to be detected and quantified. The adaptor is constructed to overlay the transilluminator and contains both a fluorescent dye that upon excitation by ultraviolet light emits light in the visible spectrum, and a conditioning substance that selects a portion of the wavelength band of the visible light produced by the fluorescent dye. The adaptor converts the ultraviolet light from the transilluminator to visible light while limiting the emissions reaching the detector to those that emanate from the sample. By the use of this adaptor, the transilluminator is adapted for use with samples labeled with dyes that are excitable by visible light and avoids exposure of the samples and the user to ultraviolet light.

公开(公告)号：CA2450385C

公开(公告)日：2007-11-13

申请号：CA2450385

申请日：2002-06-19

Applicant: BIO RAD LABORATORIES

Inventor： NAGHIEH HAMID R ,  BHATT NEERAJ ,  KOTCHOU KEITH ,  GINGRICH JEFFREY

IPC: G01N21/64 ,  G01N21/93 ,  G01N21/27 ,  G01N27/447 ,  G01N33/483

Abstract: The optical imaging of two-dimensional solute zone arrays in electrophoresis gels is corrected for nonuniformities in the optical system such as those arising from the light source or from light dispersion underneath the gel. T he correction is achieved by the use of a reference plate that responds to a light source uniformly along its length and width by being either uniformly light absorptive or uniformly light transmissive, or by emitting light upon excitation. Thus, any nonuniformities or deviations in the image of the reference plate arise only from nonuniformities or deviations within the optical system. Analogous corrections are made in other two-dimensional assa y images, such as microarrays and microtiter plates.

公开(公告)号：EP2095104A4

公开(公告)日：2010-03-10

申请号：EP07865871

申请日：2007-12-19

Applicant: BIO RAD LABORATORIES

Inventor： MEHTA SURESH N ,  BHATT NEERAJ ,  MCDONALD KEVIN A

IPC: G01N30/95 ,  G01N27/447

CPC classification number: G01N27/44726 ,  G01N21/5911 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N30/95 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/062

Abstract: Images of two-dimensional chromatograms or other sample arrays are formed on a scanning instrument that utilizes a line of illumination light that sweeps the length of the array either by moving across the array or by the array moving relative to the light, in either case scanning the entire two-dimensional array with a unidirectional pass of the moving component. The use of a CCD equipped with time delay integration allows the instrument to form an enhanced image.