公开(公告)号：US20130135609A1

公开(公告)日：2013-05-30

申请号：US13729171

申请日：2012-12-28

Applicant: Chemlmage Corporation

Inventor： Charles Gardner, JR. ,  Matthew Nelson

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0264 ,  G01J3/2823 ,  G01J3/36 ,  G01N21/6456 ,  G01N21/65 ,  G01N33/22 ,  G01N2021/1738 ,  G01N2021/174 ,  G01N2021/1744

Abstract: The present disclosure provides for a system and method for detecting unknown materials. A test data set, which may comprise a hyperspectral data set, is generated representative of a first location. The test data set may be analyzed to determine a second location which may be interrogated using a Raman spectroscopic device to generate a Raman data set. The Raman data set may be analyzed to associated an unknown material with a known material such as: a chemical material, a biological material, an explosive material, a hazardous material, a drug material, and combinations thereof.

Abstract translation: 本公开提供了用于检测未知材料的系统和方法。 产生代表第一位置的测试数据集，其可以包括高光谱数据集。 可以分析测试数据集以确定可以使用拉曼光谱装置询问的第二位置，以产生拉曼数据集。 可以分析拉曼数据集，以将已知材料与未知材料相关联，例如：化学材料，生物材料，爆炸材料，危险材料，药物材料及其组合。

公开(公告)号：US20130038877A1

公开(公告)日：2013-02-14

申请号：US13651600

申请日：2012-10-15

Applicant: Chemlmage Corporation

Inventor： Matthew Nelson

IPC: G01N21/25

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A high passband transmission ratio is obtained by splitting a light beam from an objective lens into two orthogonally-polarized components processed along distinct paths through two independently controllable liquid crystal tunable filters (LCTFs). The filtered portions may be combined at an imaging plane or may be separately processed without recombining. Using two LCTFs, the arrangements discussed herein may ideally achieve 100% transmission in a single passband when two orthogonal components of a single wavelength are tuned, or 50% transmission at two distinct passbands when two orthogonal components from two different wavelengths (one component from each wavelength) are tuned. The dual polarization configuration described herein may be used to improve contrast or detected signal intensity in various microscopy and spectroscopic/chemical imaging applications and to increase the speed of detection.

Abstract translation: 通过将来自物镜的光束分成通过两个独立可控的液晶可调滤波器（LCTF）沿不同路径处理的两个正交极化分量，获得高通带传输比。 过滤部分可以在成像平面处组合，或者可以在不重新组合的情况下分开处理。 使用两个LCTF，当两个不同波长的两个正交分量（来自两个不同波长的一个分量）（两个不同波长的两个正交分量） 波长）调整。 本文描述的双极化配置可用于改善各种显微镜和分光/化学成像应用中的对比度或检测信号强度，并提高检测速度。

公开(公告)号：US20140198315A1

公开(公告)日：2014-07-17

申请号：US14155883

申请日：2014-01-15

Applicant: Chemlmage Corporation

Inventor： Ryan Priore ,  Patrick Treado ,  Matthew Nelson

IPC: G01J3/51

CPC classification number: G01J3/32 ,  G01J3/0224 ,  G01J3/36 ,  G01J3/457 ,  G01J2003/1213 ,  G01N21/31

Abstract: A system and method for detecting at least one target of interest using at least two conformal filters in a dual polarization configuration. A plurality of interacted photons are collected from a sample comprising at least one analyte of interest. The plurality of interacted photons are separated into at least a first and second optical component. The first optical component is passed through a first conformal filter and the second optical component is passed through a second conformal filter. A Data set corresponding to each filtered optical component is generated and an optical computation is applied to assess at least one characteristic of the analyte.

Abstract translation: 一种用于在双极化配置中使用至少两个共形滤波器来检测至少一个感兴趣的目标的系统和方法。 从包含至少一种目的分析物的样品收集多个相互作用的光子。 多个相互作用的光子被分成至少第一和第二光学部件。 第一光学部件通过第一保形过滤器，并且第二光学部件通过第二适形过滤器。 生成对应于每个滤波的光学部件的数据集，并应用光学计算来评估分析物的至少一个特性。

公开(公告)号：US20130082180A1

公开(公告)日：2013-04-04

申请号：US13626474

申请日：2012-09-25

Applicant: Chemlmage Corporation

Inventor： Ryan Priore ,  Shona Stewart ,  Patrick J. Treado ,  Matthew Nelson ,  Alan Wilson

IPC: G01N21/55 ,  G01J3/28 ,  G01N21/59 ,  G01N21/64

CPC classification number: G01N21/55 ,  G01J3/28 ,  G01N21/59 ,  G01N21/64 ,  G01N21/6402 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6417 ,  G02B21/16

Abstract: A system and method for multipoint assessment of a biological sample, which may comprise a bodily fluid. The sample is irradiated to generate a plurality of interacted photons. These photons are assessed to evaluate a component of the sample. The component may comprise at least one of: a protein, a flavonoid, a keratinoid, a metabolite, an electrolyte, an enzyme, and combinations thereof. The component may also comprise at least one of: a chemical agent, a biological toxin, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof. The evaluation may comprise determining at least one of: a disease state, a disease stage, a metabolic state, a hydration state, an inflammatory state, and combinations thereof.

Abstract translation: 用于生物样品的多点评估的系统和方法，其可以包括体液。 照射样品以产生多个相互作用的光子。 评估这些光子以评估样品的组分。 该组分可以包括以下至少一种：蛋白质，类黄酮，角质素，代谢物，电解质，酶及其组合。 该组分还可以包含以下至少一种：化学试剂，生物毒素，微生物，细菌，原生动物，病毒及其组合。 评估可以包括确定疾病状态，疾病阶段，代谢状态，水合状态，炎症状态及其组合中的至少一个。

公开(公告)号：US20140268104A1

公开(公告)日：2014-09-18

申请号：US13913303

申请日：2013-06-07

Applicant: Chemlmage Corporation

Inventor： Patrick J. Treado ,  Matthew Nelson ,  Charles W. Gardner

IPC: G01J3/44 ,  G01J3/51

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/32 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.

Abstract translation: 包含未知材料的第一位置可以使用双极化配置中的SWIR高光谱成像进行扫描。 还可以进行测量，从而确定人是否存在。 本次测量可能会实现我对LWIR数据的评估，运动传感器获取的数据及其组合。 如果不存在人，则可以使用拉曼光谱技术询问第二位置，从而获得表示感兴趣区域的拉曼数据集。 可以评估该拉曼数据集以将未知材料与已知材料相关联。 可以通过将拉曼数据集与参考数据库中的一个或多个参考数据集进行比较来实现该评估，其中每个参考数据集与已知材料相关联。

公开(公告)号：US20130214162A1

公开(公告)日：2013-08-22

申请号：US13758742

申请日：2013-02-04

Applicant: Chemlmage Corporation

Inventor： Patrick J. Treado ,  Matthew Nelson ,  Charles W. Gardner

IPC: G01J3/28

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/32 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/0057

Abstract: A system and method for analyzing unknown materials on surfaces including, but not limited to, chemical materials, biological materials, hazardous materials, drug materials, and non-threat materials using SWIR and/or extended range SWIR hyperspectral and spectroscopic techniques. A system comprising a collection optics, a tunable filter, and a first detector for generating a test data set representative of the unknown sample. A second detector, comprising a visible imaging device, may be configured to operate in a scanning mode to locate areas of interest for further interrogation using SWIR. A method comprising generating a SWIR test data set representative of the unknown sample and analyzing the unknown sample to detect, identify and/or distinguish an unknown material as a known material. This analysis may be achieved by comparing the test data set to a reference data set using at least one chemometric technique.

Abstract translation: 用于使用SWIR和/或扩展范围的SWIR高光谱和光谱技术分析表面上的未知材料的系统和方法，包括但不限于化学材料，生物材料，危险材料，药物材料和非威胁材料。 一种包括收集光学器件，可调谐滤波器和用于生成表示未知样品的测试数据集的第一检测器的系统。 包括可见成像装置的第二检测器可以被配置为以扫描模式操作，以使用SWIR来定位要进一步询问的感兴趣区域。 一种方法，包括生成代表未知样品的SWIR测试数据集，并分析未知样品以检测，识别和/或区分未知材料作为已知材料。 可以通过使用至少一种化学计量技术将测试数据集与参考数据集进行比较来实现该分析。