公开(公告)号：US20140093147A1

公开(公告)日：2014-04-03

申请号：US13998776

申请日：2013-12-03

Applicant: Chemlmage Corporation

Inventor： Shona Stewart ,  Patrick Treado ,  Heather Kirschner ,  Alan Wilson ,  Ryan Priore ,  Jeffrey Cohen ,  Serena Augustine

IPC: G01N21/25

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.

Abstract translation: 一种使用高光谱成像分析器官样品的方法，包括照亮器官样品以产生相互作用的光子，收集相互作用的光子并使相互作用的光子通过可调滤光器。 检测过滤的相互作用的光子以产生高光谱图像。 生成亮场图像并与高光谱图像相关联。 提取并分析来自感兴趣位置的光谱，以评估器官样品的特征。 系统可以包括用于照亮器官样本并产生相互作用的光子的照明源，用于收集相互作用的光子的收集光学器件和用于过滤相互作用的光子的可调滤波器。 检测器被配置为检测滤波的光子并产生至少一个高光谱图像。 检测器还可以被配置为产生代表器官样本的至少一个亮场图像。

公开(公告)号：US20140198315A1

公开(公告)日：2014-07-17

申请号：US14155883

申请日：2014-01-15

Applicant: Chemlmage Corporation

Inventor： Ryan Priore ,  Patrick Treado ,  Matthew Nelson

IPC: G01J3/51

CPC classification number: G01J3/32 ,  G01J3/0224 ,  G01J3/36 ,  G01J3/457 ,  G01J2003/1213 ,  G01N21/31

Abstract: A system and method for detecting at least one target of interest using at least two conformal filters in a dual polarization configuration. A plurality of interacted photons are collected from a sample comprising at least one analyte of interest. The plurality of interacted photons are separated into at least a first and second optical component. The first optical component is passed through a first conformal filter and the second optical component is passed through a second conformal filter. A Data set corresponding to each filtered optical component is generated and an optical computation is applied to assess at least one characteristic of the analyte.

Abstract translation: 一种用于在双极化配置中使用至少两个共形滤波器来检测至少一个感兴趣的目标的系统和方法。 从包含至少一种目的分析物的样品收集多个相互作用的光子。 多个相互作用的光子被分成至少第一和第二光学部件。 第一光学部件通过第一保形过滤器，并且第二光学部件通过第二适形过滤器。 生成对应于每个滤波的光学部件的数据集，并应用光学计算来评估分析物的至少一个特性。

公开(公告)号：US20130082180A1

公开(公告)日：2013-04-04

申请号：US13626474

申请日：2012-09-25

Applicant: Chemlmage Corporation

Inventor： Ryan Priore ,  Shona Stewart ,  Patrick J. Treado ,  Matthew Nelson ,  Alan Wilson

IPC: G01N21/55 ,  G01J3/28 ,  G01N21/59 ,  G01N21/64

CPC classification number: G01N21/55 ,  G01J3/28 ,  G01N21/59 ,  G01N21/64 ,  G01N21/6402 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6417 ,  G02B21/16

Abstract: A system and method for multipoint assessment of a biological sample, which may comprise a bodily fluid. The sample is irradiated to generate a plurality of interacted photons. These photons are assessed to evaluate a component of the sample. The component may comprise at least one of: a protein, a flavonoid, a keratinoid, a metabolite, an electrolyte, an enzyme, and combinations thereof. The component may also comprise at least one of: a chemical agent, a biological toxin, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof. The evaluation may comprise determining at least one of: a disease state, a disease stage, a metabolic state, a hydration state, an inflammatory state, and combinations thereof.

Abstract translation: 用于生物样品的多点评估的系统和方法，其可以包括体液。 照射样品以产生多个相互作用的光子。 评估这些光子以评估样品的组分。 该组分可以包括以下至少一种：蛋白质，类黄酮，角质素，代谢物，电解质，酶及其组合。 该组分还可以包含以下至少一种：化学试剂，生物毒素，微生物，细菌，原生动物，病毒及其组合。 评估可以包括确定疾病状态，疾病阶段，代谢状态，水合状态，炎症状态及其组合中的至少一个。

公开(公告)号：US20140016116A1

公开(公告)日：2014-01-16

申请号：US13987046

申请日：2013-06-28

Applicant: Chemlmage Corporation

Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

IPC: G01N21/84

CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。