公开(公告)号：US20140093147A1

公开(公告)日：2014-04-03

申请号：US13998776

申请日：2013-12-03

Applicant: Chemlmage Corporation

Inventor： Shona Stewart ,  Patrick Treado ,  Heather Kirschner ,  Alan Wilson ,  Ryan Priore ,  Jeffrey Cohen ,  Serena Augustine

IPC: G01N21/25

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.

Abstract translation: 一种使用高光谱成像分析器官样品的方法，包括照亮器官样品以产生相互作用的光子，收集相互作用的光子并使相互作用的光子通过可调滤光器。 检测过滤的相互作用的光子以产生高光谱图像。 生成亮场图像并与高光谱图像相关联。 提取并分析来自感兴趣位置的光谱，以评估器官样品的特征。 系统可以包括用于照亮器官样本并产生相互作用的光子的照明源，用于收集相互作用的光子的收集光学器件和用于过滤相互作用的光子的可调滤波器。 检测器被配置为检测滤波的光子并产生至少一个高光谱图像。 检测器还可以被配置为产生代表器官样本的至少一个亮场图像。

公开(公告)号：US20130082180A1

公开(公告)日：2013-04-04

申请号：US13626474

申请日：2012-09-25

Applicant: Chemlmage Corporation

Inventor： Ryan Priore ,  Shona Stewart ,  Patrick J. Treado ,  Matthew Nelson ,  Alan Wilson

IPC: G01N21/55 ,  G01J3/28 ,  G01N21/59 ,  G01N21/64

CPC classification number: G01N21/55 ,  G01J3/28 ,  G01N21/59 ,  G01N21/64 ,  G01N21/6402 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6417 ,  G02B21/16

Abstract: A system and method for multipoint assessment of a biological sample, which may comprise a bodily fluid. The sample is irradiated to generate a plurality of interacted photons. These photons are assessed to evaluate a component of the sample. The component may comprise at least one of: a protein, a flavonoid, a keratinoid, a metabolite, an electrolyte, an enzyme, and combinations thereof. The component may also comprise at least one of: a chemical agent, a biological toxin, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof. The evaluation may comprise determining at least one of: a disease state, a disease stage, a metabolic state, a hydration state, an inflammatory state, and combinations thereof.

Abstract translation: 用于生物样品的多点评估的系统和方法，其可以包括体液。 照射样品以产生多个相互作用的光子。 评估这些光子以评估样品的组分。 该组分可以包括以下至少一种：蛋白质，类黄酮，角质素，代谢物，电解质，酶及其组合。 该组分还可以包含以下至少一种：化学试剂，生物毒素，微生物，细菌，原生动物，病毒及其组合。 评估可以包括确定疾病状态，疾病阶段，代谢状态，水合状态，炎症状态及其组合中的至少一个。