公开(公告)号：WO2012018519A1

公开(公告)日：2012-02-09

申请号：PCT/US2011/044484

申请日：2011-07-19

Applicant: ISP INVESTMENTS INC. ,  NARAYANAN, Kolazi, S. ,  PROSISE, William, E. ,  CORRING, Robert

Inventor： NARAYANAN, Kolazi, S. ,  PROSISE, William, E. ,  CORRING, Robert

IPC: A61K8/02

CPC classification number: A61K8/8176 ,  A61K8/06 ,  A61K8/37 ,  A61K8/463 ,  A61K8/466 ,  A61K8/922 ,  A61K2800/21 ,  A61K2800/30 ,  A61Q11/00

Abstract: An aqueous, heat and cold stable, non-alcoholic or slightly-alcoholic microemulsion based antimicrobial mouthwash composition with improved antimicrobial efficacy. The composition comprises a unique water-soluble matrix composite, at least one water-immiscible or water- insoluble antimicrobial agent, and optionally, a preservative or preservative system, a weak carboxylic acid, a coloring agent and other additives. Examples of antimicrobial agents include menthol, thymol, eucalyptol and/or methyl salicylate. A process for preparing the oral care composition is also disclosed.

Abstract translation: 一种具有改善的抗菌功效的含水，热和冷的稳定的非酒精或微酒精微乳液的抗微生物漱口水组合物。 该组合物包含独特的水溶性基质复合物，至少一种与水不混溶或不溶于水的抗微生物剂，以及任选的防腐剂或防腐剂体系，弱羧酸，着色剂和其它添加剂。 抗微生物剂的实例包括薄荷醇，百里酚，桉树脑油酸和/或水杨酸甲酯。 还公开了一种制备口腔护理组合物的方法。

公开(公告)号：WO2014078613A8

公开(公告)日：2014-05-22

申请号：PCT/US2013/070220

申请日：2013-11-15

Applicant: ISP INVESTMENTS INC.

Inventor： PROSISE, William, E. ,  GIANNONE, Gillian ,  LYNN, Jeffrey ,  GRIGORAS, Cristian

IPC: A61K8/81

Abstract: The present invention provides oral care compositions for treating tooth sensitivity. The composition comprises a synergistic mixture containing a copolymer having at least one repeating unit of alkyl vinyl ether functionality and a monomer having at least one repeating unit of ethylenically unsaturated dicarboxylic acid or anhydride functionality present in an amount of about 0.1 to about 50% (w /w) of the total mixture; and a homo polymer having repeating unit of alkyl vinyl ether functionality present in an amount of about 0.1 to about 50% (w / w) of the total mixture. These synergistic mixtures of polymers act as barriers for dentin flow and reduce pain and discomfort caused by tooth sensitivity and exhibits at least 60% average reduction in dentin flow.

公开(公告)号：WO2007092368A2

公开(公告)日：2007-08-16

申请号：PCT/US2007/003007

申请日：2007-02-05

Applicant: GOSMILE, INC. ,  ISP INVESTMENTS INC.

Inventor： PROSISE, William, E. ,  LEVINE, Jonathan, B.

CPC classification number: A61Q11/02 ,  A61K8/22 ,  A61K8/8176 ,  A61Q11/00

Abstract: A tooth whitening delivery system including a single-dose applicator (10) and a liquid, substantially anhydrous tooth whitener composition of predetermined viscosity contained in said applicator (10) for delivery of a tooth-whitening amount of active whitening ingredient from said applicator onto teeth, with effective bioadhesion and retention thereof, and, thereupon, sufficient penetration of said ingredient through the tooth enamel providing efficacious bleaching of stained teeth, comprising, by weight, (a) 10 % to 75 % of a complex which is (i) a mixture of 78 to 90 % of water soluble polyvinylpyrrolidone (PVP) having K-values of K-12 to K-120 and (ii) 10 to 22 % of H 2 O 2 ; releasing 1 to 20 % of active H 2 O 2 from said complex onto a tooth surface; (b) 0 to 20 % of PVP K-60 to K-90, said PVP being present in said composition at a K-value of the PVP in said complex of less than 30, and/or the amount of PVP therein is less than 20 %, and (c) 30 to 90 % of a substantially anhydrous solvent, said composition having a Brookfield viscosity of 75 to 300 cps, an in vitro bioadhesion/retention on hydroxyapatite (HAP) of at least 10 % after 5 minutes while immersed in water, and a bleaching efficacy defined by Δ E values of at least 5 in the CIE (L*a*b*) color scale.

Abstract translation: 一种牙齿增白递送系统，包括单剂量施用器（10）和包含在所述施用器（10）中的预定粘度的液体，基本上无水的牙齿增白剂组合物，用于将牙齿增白量的活性美白成分从所述施用器递送到牙齿上 具有有效的生物粘附和保留，并且因此所述成分通过牙釉质的充分穿透提供染色牙齿的有效漂白，其包含（a）10重量％至75重量％的复合物，其为（i） 具有K-12至K-120的K值的78至90％的水溶性聚乙烯吡咯烷酮（PVP）和（ii）H 2 O 2 O 2的10至22％ SUB>; 将1〜20％的活性H 2 O 2 O 2从所述络合物释放到牙齿表面上; （b）0至20％的PVP K-60至K-90，所述PVP以所述复合物中的PVP的K值小于30存在于所述组合物中，和/或其中PVP的量较少 20％以上，（c）30〜90％的基本无水溶剂，所述组合物的布氏粘度为75〜300cps，羟基磷灰石（HAP）的体外生物粘附/保留在5分钟后至少为10％，而 浸在水中，漂白效果定义为？ CIE（L * a * b *）色标中的E值至少为5。

公开(公告)号：WO1991014716A1

公开(公告)日：1991-10-03

申请号：PCT/US1991001455

申请日：1991-03-04

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  TAZI, Mohammed ,  LOGIN, Robert, B. ,  PLOCHOCKA, Krystyna ,  HALDAR, Rama, K. ,  GANGADHARAN, Balgopal ,  PROSISE, William, E.

IPC: C08F08/12

CPC classification number: C08F220/06 ,  A61K6/0026 ,  C08L33/08 ,  C08L33/10 ,  C08L35/08 ,  C08L1/08 ,  C08L39/06 ,  C08L31/04 ,  C08L1/28 ,  C08L89/04 ,  C08L5/04

Abstract: Slurry copolymerization of maleic anhydride with (meth)acrylic acid and, optionally, with C1-C4 alkyl vinyl ether in a cosolvent system of cyclohexane and ethyl acetate yields a pumpable slurry, from which uniform, fine, white powders having a predetermined weight average molecular weight of about 10,000 to one million, preferably about 30,000 to 400,000 are obtained. The copolymers are useful in a denture adhesive composition which is a mixed partial salt of the copolymer.

Abstract translation: 马来酸酐与（甲基）丙烯酸和任选地与C 1 -C 4烷基乙烯基醚在环己烷和乙酸乙酯的共溶剂体系中的淤浆共聚产生可泵送的浆料，从其中可以得到具有预定重均分子量的均匀的细的白色粉末 重量约10,000至100万，优选约30,000至400,000。 共聚物可用于义齿粘合剂组合物，其是共聚物的混合的部分盐。

公开(公告)号：WO2011130009A1

公开(公告)日：2011-10-20

申请号：PCT/US2011/030642

申请日：2011-03-31

Applicant: ISP INVESTMENTS INC. ,  PROSISE, William, E. ,  CORRING, Robert

Inventor： PROSISE, William, E. ,  CORRING, Robert

IPC: A61K8/21

CPC classification number: A61K8/8176 ,  A61K8/21 ,  A61K8/25 ,  A61K2800/48 ,  A61Q11/00

Abstract: Oral care compositions containing an oral care ingredient and a thickening agent, wherein the thickening agent comprises a strongly swellable, lightly to moderately crosslinked polyvinyl pyrrolidone. The polyvinyl pyrrolidone thickening agent is characterized by an aqueous gel volume of about 15 to 150 ml/g and a Brookfield viscosity of at least 10,000 cps for a 5% aqueous solution at 25° C.

Abstract translation: 含有口腔护理成分和增稠剂的口腔护理组合物，其中所述增稠剂包含强溶胀，轻度至中度交联的聚乙烯吡咯烷酮。 聚乙烯吡咯烷酮增稠剂的特征在于在25℃下5％水溶液的水凝胶体积为约15至150ml / g，Brookfield粘度为至少10,000cps。

公开(公告)号：WO2007001828A1

公开(公告)日：2007-01-04

申请号：PCT/US2006/022940

申请日：2006-06-13

Applicant: ISP INVESTMENTS INC. ,  PROSISE, William, E.

Inventor： PROSISE, William, E.

IPC: A61K8/20 ,  A61K8/22 ,  A61K8/30 ,  A61K8/38 ,  A61Q11/00

CPC classification number: A61Q11/00 ,  A61K8/22 ,  A61K8/8176 ,  A61K2800/31

Abstract: A liquid, substantially anhydrous tooth whitener composition for delivery of a tooth-whitening amount of active whitening ingredient onto teeth, with effective bioadhesion and retention thereof, and, thereupon, sufficient penetration of said ingredient through the tooth enamel, providing efficacious bleaching of stained teeth, comprising, by weight, (a) 10% to 75% of a complex which is (i) a mixture of 78 to 90% of water soluble polyvinylpyrrolidone (PVP) having K-values of K-12 to K-120 and (ii) 10 to 22% of H2O2; releasing 1 to 20% of active H 2 O 2 from said complex onto a tooth surface; (b) 0 to 20% of PVP K-60 to K-90, said PVP being present in said composition at a K-value of the PVP in said complex of less than 30, and/or the amount of PVP therein is less than 20%, and (c) 30 to 90% of a substantially anhydrous solvent, said composition having a Brookfield viscosity of 50 to 10,000 cps, an in vitro bioadhesion/retention on hydroxyapatite (HAP) of at least 10% after 5 minutes while immersed in water, and a bleaching efficacy defined by Δ E values of at least 5 in the CIE (L*a*b*) color scale.

Abstract translation: 一种液体，基本上无水的牙齿增白剂组合物，用于将牙齿增白剂量的活性增白成分递送到牙齿上，具有有效的生物粘附和保留，并且因此足以使所述成分穿透牙釉质，从而提供染色牙齿的有效漂白 ，包含（a）10％至75％的复合物，其为（i）具有K-12至K-120的K值的78至90％的水溶性聚乙烯吡咯烷酮（PVP）的混合物和（ ii）10〜22％的H 2 O 2; 将1〜20％的活性H 2 O 2 O 2从所述络合物释放到牙齿表面上; （b）0至20％的PVP K-60至K-90，所述PVP以所述复合物中的PVP的K值小于30存在于所述组合物中，和/或其中PVP的量较少 20％以上，（c）30〜90％的基本无水溶剂，所述组合物的布氏粘度为50〜10,000cps，5分钟后羟基磷灰石（HAP）的体外生物粘附/保留率为10％以上，而 浸在水中，漂白效果定义为？ CIE（L * a * b *）色标中的E值至少为5。

公开(公告)号：WO2004041102A2

公开(公告)日：2004-05-21

申请号：PCT/US2003/032404

申请日：2003-10-14

Applicant: ISP INVESTMENTS INC.

Inventor： PROSISE, William, E. ,  BEE, Timothy, G. ,  DRZEWINSKI, Michael, A.

IPC: A61C

CPC classification number: A61K8/0208 ,  A61C19/066 ,  A61K8/22 ,  A61K8/345 ,  A61K8/8176 ,  A61Q11/00

Abstract: A delivery system for delivering a tooth whitening substance to a surface of an oral cavity, comprising a film of flexible malleable polymer material having a tooth whitening substance as an integral component of said film, thus providing an active on said oral surface when said film is adhered to the oral surface, said film having a dissolution rate in the aqueous medium of the oral cavity such that the tooth whitening substance can release its active upon said oral surface to act effectively thereon within a predetermined period of time, said film being disintegrable thereafter after effecting its tooth whitening action.

Abstract translation: 一种用于将牙齿增白物质递送至口腔表面的递送系统，该递送系统包括具有牙齿增白物质作为所述薄膜的整体组分的柔性可延展聚合物材料的薄膜，从而提供活性成分 当所述膜粘附到口腔表面时，所述膜在口腔的水性介质中具有溶解速率，使得牙齿增白物质可以在所述口腔表面上释放其活性物质，以在预定时间段内有效地作用于其上 在影响牙齿美白作用之后，所述胶片可以分解。

公开(公告)号：WO1998016565A1

公开(公告)日：1998-04-23

申请号：PCT/US1997017575

申请日：1997-09-30

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  PROSISE, William, E. ,  KWAK, Yoon, Tae

IPC: C08F222/06

CPC classification number: C09J135/08 ,  C08L1/26 ,  C08L2666/26 ,  A61K6/0026 ,  C08L35/08 ,  C08L33/10

Abstract: This invention relates to an improved denture adhesive composition having extended holding power accompanied by adhesion building properties during use and having increased gel adhesion, which composition consists essentially of (a) from about 10 to about 35 wt.% lower alkyl vinyl ether-maleic acid copolymer wherein from 0 to about 90 wt.% of the copolymer carboxyl units are converted to a mixture of salts selected from the group of calcium, sodium, strontium, aluminum, zinc, magnesium and potassium; (b) 10-35 wt.% of a crosslinked terpolymer of alkyl vinyl ether, maleic anhydride and a C16-C20 alkyl acrylate or methacrylate, or vinyl ether; crosslinked with a C6-C14 diene, e.g. 9-decadiene, and their salts; (c) 10-35 wt.% of a cohesive agent; in a weight ratio of between about 2:1 and about 1:2 with respect to the copolymer; and (d) from about 30 to about 70 wt.% of an oil base as a carrier.

Abstract translation: 本发明涉及具有延长的保持力的改进的义齿粘合剂组合物，其在使用期间具有粘附建立性能并且具有增加的凝胶粘附性，该组合物基本上由（a）约10至约35重量％的低级烷基乙烯基醚 - 马来酸 共聚物，其中0至约90重量％的共聚物羧基单元转化为选自钙，钠，锶，铝，锌，镁和钾的盐的混合物; （b）10-35重量％的烷基乙烯基醚，马来酸酐和C16-C20烷基丙烯酸酯或甲基丙烯酸酯或乙烯基醚的交联三元共聚物; 与C 6 -C 14二烯交联，例如。 9-癸二烯及其盐; （c）10-35重量％的内聚剂; 相对于共聚物的重量比为约2:1至约1:2; 和（d）约30至约70重量％的油基作为载体。

公开(公告)号：EP1040144A1

公开(公告)日：2000-10-04

申请号：EP98948527.1

申请日：1998-09-22

Applicant: ISP INVESTMENTS INC.

Inventor： PLOCHOCKA, Krystyna ,  PROSISE, William, E. ,  ZHANG, Huixiang

IPC: C08F222/04 ,  C08F222/06 ,  C08F216/12 ,  C08F210/10 ,  C08L35/08 ,  C08K5/09

CPC classification number: C08F222/06 ,  A61K8/347 ,  A61K8/8164 ,  A61Q11/00 ,  C08K5/0008 ,  C08L35/08 ,  A61K6/0026

Abstract: This invention relates to high molecular weight terpolymers of maleic anhydride, C1-C4 alkyl vinyl ethers and isobutylene, and to a solvent-free process for making such terpolymers, which are particularly useful in denture adhesive and dentifrice compositions.

公开(公告)号：EP2919750A1

公开(公告)日：2015-09-23

申请号：EP13854702.1

申请日：2013-11-15

Applicant: Isp Investments Inc.

Inventor： PROSISE, William, E. ,  GIANNONE, Gillian ,  LYNN, Jeffrey ,  GRIGORAS, Cristian

IPC: A61K8/81

CPC classification number: A61K8/8164 ,  A61K8/8129 ,  A61K2800/594 ,  A61K2800/92 ,  A61Q11/00

Abstract: The present invention provides oral care compositions for treating tooth sensitivity. The composition comprises a synergistic mixture containing a copolymer having at least one repeating unit of alkyl vinyl ether functionality and a monomer having at least one repeating unit of ethylenically unsaturated dicarboxylic acid or anhydride functionality present in an amount of about 0.1 to about 50% (w /w) of the total mixture; and a homo polymer having repeating unit of alkyl vinyl ether functionality present in an amount of about 0.1 to about 50% (w / w) of the total mixture. These synergistic mixtures of polymers act as barriers for dentin flow and reduce pain and discomfort caused by tooth sensitivity and exhibits at least 60% average reduction in dentin flow.