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公开(公告)号：CA2915475A1
公开(公告)日：2014-11-27
申请号：CA2915475
申请日：2014-05-27
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , FOSTER EVAN , FONSECA JORGE , NURSE JAMES , STRAUB THEODORE
IPC: B01L3/00
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
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Patent Agency Ranking
公开(公告)号：WO2013138706A3
公开(公告)日：2014-01-16
申请号：PCT/US2013032002
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , NURSE JAMES C , MAHER KEVIN , FONSECA JORGE , GHENCIU ELIODOR , FOSTER EVAN
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L2200/141 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.
Abstract translation: 用于保持多个生物样品的制品包括基材，其包含基材中的第一表面和相对的第二表面和多个反应位点。 每个反应位点从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状并且被配置为通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应部位的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。
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公开(公告)号：SG11201406039WA
公开(公告)日：2014-11-27
申请号：SG11201406039W
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , NURSE JAMES C , MAHER KEVIN , FONSECA JORGE , GHENCIU ELIODOR , FOSTER EVAN
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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公开(公告)号：SG11201510642UA
公开(公告)日：2016-02-26
申请号：SG11201510642U
申请日：2014-05-27
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , FOSTER EVAN , FONSECA JORGE , NURSE JAMES , STRAUB THEODORE
IPC: B01L3/00
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The suppose is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
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公开(公告)号：SG11202108157WA
公开(公告)日：2021-08-30
申请号：SG11202108157W
申请日：2020-01-30
Applicant: LIFE TECH HOLDINGS PTE LIMITED , LIFE TECHNOLOGIES CORP
Inventor： BOO KUAN MOON , TEO WEI FUH , TAN ZEQI , LAU SOO YONG , SIA MING TIONG , SOH WOON LIANG , LAM CHING YEE , DONG SHAN HUA , HABERSTROH MARC , PALLAS MICHAEL , SANGHA HARDEEP
Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.
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公开(公告)号：AU2014268299A1
公开(公告)日：2016-01-21
申请号：AU2014268299
申请日：2014-05-27
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , FOSTER EVAN , FONSECA JORGE , NURSE JAMES , STRAUB THEODORE
IPC: B01L3/00
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
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