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    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    3.
    发明专利
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 未知

    公开(公告)号：SG11201401919TA

    公开(公告)日：2014-10-30

    申请号：SG11201401919T

    申请日：2012-09-28

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： MAHER KEVIN ,  CHEN MINGSONG ,  FREUDENTHAL JACOB ,  BOO KUAN MOON ,  LAU SOO YONG ,  FORTESCUE DAVID ,  SHEN MING ,  SOH WOON LIANG TERENCE

    IPC: G01N21/64

    Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

    SYSTEMS AND METHODS FOR CONTAINING BIOLOGICAL SAMPLES
    5.
    发明申请
    SYSTEMS AND METHODS FOR CONTAINING BIOLOGICAL SAMPLES 审中-公开
    包含生物样品的系统和方法

    公开(公告)号：WO2013138706A3

    公开(公告)日：2014-01-16

    申请号：PCT/US2013032002

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： PALLAS MICHAEL ,  NURSE JAMES C ,  MAHER KEVIN ,  FONSECA JORGE ,  GHENCIU ELIODOR ,  FOSTER EVAN

    IPC: B01L3/00 ,  B81C1/00 ,  C03C15/00 ,  C03C23/00

    CPC classification number: B01L3/50857 ,  B01L3/50 ,  B01L3/50851 ,  B01L2200/141 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/161 ,  C12Q1/6806 ,  C12Q1/686 ,  G03F7/2002

    Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.

    Abstract translation: 用于保持多个生物样品的制品包括基材，其包含基材中的第一表面和相对的第二表面和多个反应位点。 每个反应位点从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状并且被配置为通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应部位的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。

    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    7.
    发明专利
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 未知

    公开(公告)号：IN3441DEN2014A

    公开(公告)日：2015-06-05

    申请号：IN3441DEN2014

    申请日：2014-04-29

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： MAHER KEVIN ,  CHEN MINGSONG ,  FREUDENTHAL JACOB ,  BOO KUAN MOON ,  LAU SOO YONG ,  FORTESCUE DAVID ,  SHEN MING ,  SOH WOON LIANG TERENCE

    IPC: G01N21/64

    Abstract: An instrument (1000) for processing and/or measuring a biological process contains an excitation source (110) a sample holder (204) an optical sensor (118) an excitation optical system (120) and an emission optical system (125). The sample holder (204) is configured to receive a plurality of biological samples. The optical sensor (118) is configured to receive an emission from the biological samples. The excitation optical system (120) is disposed along an excitation optical path (126) and is configured to direct the electromagnetic radiation from the excitation source (110) to the biological samples. The emission optical system (125) is disposed along an emission optical path (128) and is configured to direct electromagnetic emissions from the biological samples to the optical sensor (118). The instrument further contains a plurality of filter assemblies (130 132) configured to be interchangeably located along at least one of the optical paths. The plurality of filter components (131) includes a first filter component (138) characterized by a first optical power and a first filter (140) having a first filter function the first filter function characterized by at least one of a first low pass wavelength or a first high pass wavelength. The second filter assembly (142) is characterized by a second optical power and a second filter (145) having a second filter function the second filter function comprising at least one of a second low pass wavelength that is different than the first low pass wavelength or a second high pass wavelength that is different than the first high pass wavelength. The second optical power differs from the first optical power by an amount sufficient to at least partially compensate for an aberration introduced by the second filter (145) relative to the first filter (140).

    SYSTEMS AND METHODS FOR ASSESSING OF BIOLOGICAL SAMPLES
    10.
    发明专利
    SYSTEMS AND METHODS FOR ASSESSING OF BIOLOGICAL SAMPLES 未知

    公开(公告)号：SG11201406040SA

    公开(公告)日：2014-11-27

    申请号：SG11201406040S

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： MAHER KEVIN

    IPC: B01L7/00 ,  C12Q1/68

    Abstract: A system for determining the number of target nucleotide molecules in a sample includes a sample holder, an excitation optical system, an optical sensor, and an emission optical system. The sample holder is configured to receive an article comprising at least 20,000 separate reaction sites. The excitation optical system comprises a light source configured to simultaneously illuminate the at least 20,000 separate reaction sites. The optical sensor comprises a predetermined number of pixels, the predetermined number of pixels being at least 20 times the number of separate reaction sites. The emission optical system comprises a system working distance from the sample holder, wherein the working distance is less than or equal to 60 millimeters.

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