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    POLYMER BRUSHES FOR IMMOBILIZING MOLECULES TO A SURFACE
    1.
    发明申请
    POLYMER BRUSHES FOR IMMOBILIZING MOLECULES TO A SURFACE 审中-公开
    用于将分子固定到表面的聚合物刷

    公开(公告)号：WO02056021A3

    公开(公告)日：2003-09-18

    申请号：PCT/US0200746

    申请日：2002-01-10

    Applicant: SYMYX TECHNOLOGIES INC ,  KLAERNER GERRIT ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  NOMULA SRINIVAS ,  PIOTTI MARCELO E ,  MAZZOLA LAURA T

    Inventor： KLAERNER GERRIT ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  NOMULA SRINIVAS ,  PIOTTI MARCELO E ,  MAZZOLA LAURA T

    IPC: C08F293/00 ,  G01N33/543 ,  C08F220/00 ,  C08J7/16 ,  G01N33/545

    CPC classification number: G01N33/54353 ,  C08F293/005

    Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

    Abstract translation: 用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有用疏水性聚合物链段修饰的表面的基底，其附着在水分散性或水溶性 具有结合探针的官能团的聚合物链段。 合成这种传感器的方法优选包括使用受控的自由基聚合技术，其允许可控结构聚合物改性底物的表面，以及使用具有在探针附着之前不需要活化的官能团的单体。 以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

    CONTROLLED FREE RADICAL EMULSION AND WATER-BASED POLYMERIZATIONS AND SEEDED METHODOLOGIES
    3.
    发明申请
    CONTROLLED FREE RADICAL EMULSION AND WATER-BASED POLYMERIZATIONS AND SEEDED METHODOLOGIES 审中-公开
    控制免费的立体乳液和水基聚合和种子方法

    公开(公告)号：WO0053640B1

    公开(公告)日：2000-12-14

    申请号：PCT/US0006176

    申请日：2000-03-08

    Applicant: SYMYX TECHNOLOGIES INC

    Inventor： KLAERNER GERRIT ,  SAFIR ADAM ,  NIELSEN RALPH B ,  JANDELEIT BERND ,  HUEFNER PETER ,  LI YUNXIAO

    IPC: C08F2/22 ,  C08F2/28 ,  C08F2/38 ,  C08F4/00 ,  C08F220/58 ,  G01N33/543

    CPC classification number: C08F220/58 ,  C08F4/00 ,  G01N33/54353

    Abstract: Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.

    Abstract translation: 具有不饱和部分的α-碳原子的硝基氧化物是用于乳液和水基聚合的有效控制剂，包括从宽范围的单体形成嵌段共聚物。 氮氧自由基可以用作自由基或与来自引发剂的残基一起加成。 乳液具有生物特性，包括聚合物链的重新引发。 此外，公开了一种用于乳液的接种方法，其包括逐步添加单体，提供对各种引发剂类型的接触。

    Polymer brushes for immobilizing molecules to a surface
    4.
    发明专利
    Polymer brushes for immobilizing molecules to a surface 未知

    公开(公告)号：AU2002246978A1

    公开(公告)日：2002-07-24

    申请号：AU2002246978

    申请日：2002-01-10

    Applicant: SYMYX TECHNOLOGIES INC

    Inventor： CHARMOT DOMINIQUE ,  KLAERNER GERRIT ,  PIOTTI MARCELO E ,  BENOIT DIDIER ,  NOMULA SRINIVAS ,  MAZZOLA LAURA T

    IPC: C08F293/00 ,  G01N33/543 ,  C08F220/00 ,  G01N33/545 ,  C08J7/16

    Abstract: Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

    POLYMER ADDITIVE FOR USE IN SEPARATION MEDIA
    5.
    发明申请
    POLYMER ADDITIVE FOR USE IN SEPARATION MEDIA 审中-公开
    聚合物添加剂用于分离介质

    公开(公告)号：WO02101375A3

    公开(公告)日：2003-04-24

    申请号：PCT/US0218583

    申请日：2002-06-12

    Applicant: SYMYX TECHNOLOGIES INC ,  BENOIT DIDIER ,  GHAJARI HASSAN ,  KLAERNER GERRIT

    Inventor： BENOIT DIDIER ,  GHAJARI NASTARAN DI ,  KLAERNER GERRIT

    IPC: G01N27/447

    CPC classification number: G01N27/44752 ,  G01N27/44747

    Abstract: An additive poly(N,N-dimethylacrylamide) polymer having a molecular weight between about 115,000 and 750,000 and a polydispersity of greater than about 1.3 is useful in a capillary electrophoretic separation medium formulation for improving the separation performance of separation of separation media, especially media that includes linear polyacrylamide.

    Abstract translation: 具有约115,000至750,000分子量和大于约1.3的多分散性的添加剂聚（N，N-二甲基丙烯酰胺）聚合物可用于毛细管电泳分离介质制剂中，用于改善分离介质，特别是介质的分离性能 包括线性聚丙烯酰胺。

    9.
    发明专利
    未知

    公开(公告)号：AT323113T

    公开(公告)日：2006-04-15

    申请号：AT00943377

    申请日：2000-07-03

    Applicant: SYMYX TECHNOLOGIES INC

    Inventor： KLAERNER GERRIT ,  NIELSEN RALPH B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA LAURA T

    IPC: C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F292/00 ,  G01N33/48 ,  C12Q1/68

    Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

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