公开(公告)号：AT323113T

公开(公告)日：2006-04-15

申请号：AT00943377

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  NIELSEN RALPH B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA LAURA T

IPC: C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F292/00 ,  G01N33/48 ,  C12Q1/68

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

公开(公告)号：AU3733800A

公开(公告)日：2000-09-28

申请号：AU3733800

申请日：2000-03-08

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  SAFIR ADAM ,  NIELSEN RALPH B ,  JANDELEIT BERND ,  HUEFNER PETER ,  LI YUNXIAO

IPC: C08F2/22 ,  C08F2/28 ,  C08F2/38 ,  C08F4/00 ,  C08F220/58 ,  G01N33/543

Abstract: Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.

公开(公告)号：CA2377739A1

公开(公告)日：2001-01-11

申请号：CA2377739

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MANSKY PAUL ,  BENOIT DIDIER ,  KLAERNER GERRIT ,  CHARMOT DOMINIQUE ,  NIELSEN RALPH B ,  JANDELEIT BERND ,  MAZZOLA LAURA T

IPC: C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F292/00 ,  G01N33/48 ,  C12Q1/68

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which compris e a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled fr ee radical polymerization techniques which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

公开(公告)号：AU5469599A

公开(公告)日：2000-02-28

申请号：AU5469599

申请日：1999-08-05

Applicant: SYMYX TECHNOLOGIES INC

Inventor： GURAM ANIL ,  BEI XIAOHONG ,  POWERS TIMOTHY ,  JANDELEIT BERND ,  CREVIER THOMAS

IPC: B01J31/24 ,  C07B61/00 ,  C07C209/10 ,  C07C211/48 ,  C07D295/023 ,  C07D295/073 ,  C07F9/50 ,  C07F9/655 ,  C07F15/00

公开(公告)号：DE60027309T2

公开(公告)日：2006-08-31

申请号：DE60027309

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  NIELSEN B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA T

IPC: C08F292/00 ,  C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  C12Q1/68 ,  G01N27/447 ,  G01N33/48 ,  G01N33/543

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

公开(公告)号：DE60027309D1

公开(公告)日：2006-05-24

申请号：DE60027309

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  NIELSEN B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA T

IPC: C08F292/00 ,  C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  C12Q1/68 ,  G01N27/447 ,  G01N33/48 ,  G01N33/543

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

公开(公告)号：AU5785400A

公开(公告)日：2001-01-22

申请号：AU5785400

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  NIELSEN RALPH B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA LAURA T

IPC: C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F292/00 ,  G01N33/48 ,  C12Q1/68

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

公开(公告)号：WO0102452A9

公开(公告)日：2002-07-25

申请号：PCT/US0018339

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  NIELSEN RALPH B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA LAURA T

IPC: C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F292/00 ,  C12Q1/68 ,  G01N33/48

CPC classification number: G01N33/54353 ,  C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/44747 ,  Y10T428/8305 ,  Y10T436/10

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

Abstract translation: 用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有表面的基底，所述基底具有用水分散性或水溶性聚合物链段修饰，所述水分散性或水溶性聚合物链段具有结合 探头。 合成这种传感器的方法优选包括使用受控的自由基聚合技术，其允许受控的结构聚合物改性基底的表面。 以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

公开(公告)号：WO0053640B1

公开(公告)日：2000-12-14

申请号：PCT/US0006176

申请日：2000-03-08

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  SAFIR ADAM ,  NIELSEN RALPH B ,  JANDELEIT BERND ,  HUEFNER PETER ,  LI YUNXIAO

IPC: C08F2/22 ,  C08F2/28 ,  C08F2/38 ,  C08F4/00 ,  C08F220/58 ,  G01N33/543

CPC classification number: C08F220/58 ,  C08F4/00 ,  G01N33/54353

Abstract: Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.

Abstract translation: 具有不饱和部分的α-碳原子的硝基氧化物是用于乳液和水基聚合的有效控制剂，包括从宽范围的单体形成嵌段共聚物。 氮氧自由基可以用作自由基或与来自引发剂的残基一起加成。 乳液具有生物特性，包括聚合物链的重新引发。 此外，公开了一种用于乳液的接种方法，其包括逐步添加单体，提供对各种引发剂类型的接触。