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公开(公告)号：EP2959275A4
公开(公告)日：2016-12-14
申请号：EP14754054
申请日：2014-02-19
Applicant: NAT UNIV SINGAPORE
Inventor： HUANG ZHIWEI , BERGHOLT MADS SYLVEST , ZHENG WEI , HO KHEK YU
CPC classification number: A61B5/0075 , A61B1/00165 , A61B5/0084 , G01J3/0218 , G01J3/0272 , G01J3/18 , G01J3/28 , G01J3/44 , G01N21/65 , G01N2201/129 , G02B23/2469 , G02B23/26
Abstract: A diagnostic instrument comprises a monochromatic light source, transmission means to transmit light from the light source to a test site, collection means to transmit scattered light from the test site, and spectral analysis apparatus to receive light from the collection means, the spectral analysis apparatus comprising a diffraction grating having a first grating element and a second grating element, wherein the first grating element diffracts light within a first wavelength range and the second grating element diffracts light within a second wavelength range, the spectral analysis apparatus further comprising a light-sensing apparatus, the first grating element arranged to diffract light onto a first area of the light-sensing apparatus and the second grating element arranged to diffract light onto a second area of the light-sensing apparatus.
Abstract translation: 诊断仪器包括单色光源，将光从光源透射到测试部位的传输装置，用于传输来自测试部位的散射光的收集装置，以及用于从收集装置接收光的光谱分析装置，光谱分析装置 包括具有第一光栅元件和第二光栅元件的衍射光栅，其中所述第一光栅元件衍射第一波长范围内的光，所述第二光栅元件在第二波长范围内衍射光，所述光谱分析设备还包括光感测 装置，第一光栅元件被布置成将光衍射到光感测装置的第一区域上，第二光栅元件被布置成将光衍射到光感测装置的第二区域上。
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2.发明公开
公开(公告)号：EP2885628A4
公开(公告)日：2016-07-20
申请号：EP13829581
申请日：2013-08-16
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , BERGHOLT MADS SYLVEST , ZHENG WEI , HO KHEK YU
IPC: G01N21/65 , A61B5/00 , A61B6/00 , A61B6/08 , A61B18/22 , G01B9/02 , G01J3/02 , G01J3/44 , G02B6/34
CPC classification number: A61B5/0075 , A61B5/0086 , A61B5/4233 , A61B5/4238 , A61B5/441 , A61B5/7221 , A61B5/7282 , A61B2562/0233 , G01J3/0221 , G01J3/0289 , G01J3/44 , G01N21/65
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3.发明公开METHODS RELATED TO REAL-TIME CANCER DIAGNOSTICS AT ENDOSCOPY UTILIZING FIBER-OPTIC RAMAN SPECTROSCOPY 审中-公开对于实时的癌症诊断方法用内窥镜使用光纤拉曼光谱
公开(公告)号：EP2870462A4
公开(公告)日：2016-03-23
申请号：EP13813251
申请日：2013-07-02
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , HO KHEK YU , BERGHOLT MADS SYLVEST , ZHENG WEI , YEOH KHAY GUAN , DURAIPANDIAN SHIYAMALA
CPC classification number: A61B5/0075 , A61B1/00165 , A61B5/0084 , A61B2560/0233 , G01J2003/4424 , G01N21/274 , G01N21/65 , G01N2021/656 , G01N2201/08 , G01N2201/12753 , G01N2201/129
Abstract: A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.
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公开(公告)号：CA2920765A1
公开(公告)日：2014-02-20
申请号：CA2920765
申请日：2013-08-16
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , BERGHOLT MADS SYLVEST , ZHENG WEI , HO KHEK YU
Abstract: A probe head for a diagnostic instrument using Raman spectroscopy for tissue measurements, the probe head comprising; a transmission optical fiber, a plurality of collection optical fibers, and a lens to transmit light from the transmission optical fiber to a test site, wherein the ends of the collection optical fibers are beveled or angled. The beveled surfaces can face towards or away from the end of the transmission fiber. Optical elements are used to gather and filter light scattered from tissue, and analysed to identify abnormal tissue.
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公开(公告)号：CA2917308C
公开(公告)日：2021-07-13
申请号：CA2917308
申请日：2013-07-02
Applicant: NAT UNIV SINGAPORE
Inventor： HUANG ZHIWEI , HO KHEK YU , BERGHOLT MADS SYLVEST , ZHENG WEI , YEOH KHAY GUAN , DURAIPANDIAN SHIYAMALA
IPC: G01N21/65 , A61B5/00 , A61B6/00 , G01J3/44 , G01N33/574
Abstract: A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.
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Patent Agency Ranking
公开(公告)号：GB2513343A
公开(公告)日：2014-10-29
申请号：GB201307338
申请日：2013-04-23
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , BERGHOLT MADS SYLVEST , ZHENG WEI , HO KHEK YU , YEOH KHAY GUAN , DURAPAIPANDIAN SHIYAMALA
Abstract: A method of calibrating a fibre-optic Raman spectroscope system 20 comprising a laser source 21, a spectroscope 30 and a fibre-optic probe 11 to transmit light from the laser source to a target and return scattered light to the spectroscope, comprises transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration spectrum and generating a transfer function, and storing the transfer function. The transfer function is then used on further spectral measurements using the spectroscope system. A method of estimating laser power in the system and a method of subtracting a background signal from a Raman spectrum is also disclosed.
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公开(公告)号：SG11201501082RA
公开(公告)日：2015-03-30
申请号：SG11201501082R
申请日：2013-08-16
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , BERGHOLT MADS SYLVEST , ZHENG WEI , HO KHEK YU
Abstract: A probe head for a diagnostic instrument, the probe head comprising; a transmission optical fiber, a plurality of collection optical fibers, and a lens to transmit light from the transmission optical fiber to a test site, wherein the ends of the collection optical fibers are bevelled.
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公开(公告)号：ES2930428T3
公开(公告)日：2022-12-12
申请号：ES13813251
申请日：2013-07-02
Applicant: NAT UNIV SINGAPORE
Inventor： HUANG ZHIWEI , HO KHEK YU , BERGHOLT MADS SYLVEST , ZHENG WEI , YEOH KHAY GUAN , DURAIPANDIAN SHIYAMALA
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公开(公告)号：SG11201408793XA
公开(公告)日：2015-01-29
申请号：SG11201408793X
申请日：2013-07-02
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , HO KHEK YU , BERGHOLT MADS SYLVEST , ZHENG WEI , YEOH KHAY GUAN , DURAIPANDIAN SHIYAMALA
IPC: G01N21/65 , A61B5/00 , A61B6/00 , G01J3/44 , G01N33/574
Abstract: A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.
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10.发明专利
公开(公告)号：CA2917308A1
公开(公告)日：2014-01-09
申请号：CA2917308
申请日：2013-07-02
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , HO KHEK YU , BERGHOLT MADS SYLVEST , ZHENG WEI , YEOH KHAY GUAN , DURAIPANDIAN SHIYAMALA
IPC: G01N21/65 , A61B5/00 , A61B6/00 , G01J3/44 , G01N33/574
Abstract: A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.
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