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公开(公告)号：WO2014046618A8
公开(公告)日：2015-04-30
申请号：PCT/SG2013000408
申请日：2013-09-19
Applicant: UNIV NANYANG TECH , UNIV SINGAPORE
Inventor： PHEE SOO JAY LOUIS , HUYNH VAN AN , WANG ZHENG , PENNY ISAAC DAVID , HO KHEK YU
CPC classification number: A61B1/00098 , A61B1/00135 , A61B1/00183 , A61B1/0057 , A61B1/0125 , A61B1/018 , A61B8/12 , A61B8/4466 , A61B34/30 , A61B34/37 , A61B34/71 , A61B2017/2906 , A61B2034/303 , F04C2270/0421
Abstract: FIG. 3A: 140 Canal à endoscope 200 Endoscope de petite taille 130 Canal pour le robot 180 Canal d'aspiration 104 Extrémité distale 100 Endoscope de grande taille A master - slave robotic endoscopy system includes a flexible primary endoscope probe having at least one tool channel for carrying a tendon-sheath driven robot arm and corresponding end effector, and a secondary endoscope probe channel for carrying an imaging endoscope. The imaging endoscope provides enhanced image capture range relative to a distal end of the primary endoscope probe by way of a secondary endoscope probe channel distal opening proximally offset from the primary endoscope probe distal end; a ramp structure disially carried by the primary endoscope probe; and/or one or more actuatable distal imaging endoscope regions. Robot arms can include joint primitives that enable robot arm / end effector manipulation in accordance with intended degrees of freedom. A set of quick connect / disconnect interfaces couple an actuation controller to one or more actuation assemblies insertable into the tool channel(s), where each actuation assembly includes tendon-sheath elements, a robot arm, and its corresponding end effector.
Abstract translation: 图。 3A：140运河à内窥镜200内窥镜小型尾巴130运河灌注机器人180运河抽吸104Extrémitédistale 100内窥镜大型尾巴主从机器人内窥镜系统包括一个灵活的主要内窥镜探头，至少有一个工具通道用于携带 腱鞘驱动的机器人臂和相应的末端执行器，以及用于承载成像内窥镜的辅助内窥镜探针通道。 成像内窥镜通过从主内窥镜探针远端向近侧偏移的辅助内窥镜探针通道远侧开口提供相对于主内窥镜探针的远端的增强的图像捕获范围; 由主内窥镜探针分别承载的斜坡结构; 和/或一个或多个可致动的远端成像内窥镜区域。 机器人手臂可以包括根据预期自由度使机器人手臂/末端执行器操纵的关节基元。 一组快速连接/断开接口将致动控制器耦合到可插入到工具通道中的一个或多个致动组件，其中每个致动组件包括腱鞘元件，机器人臂及其对应的端部执行器。
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公开(公告)号：EP2959275A4
公开(公告)日：2016-12-14
申请号：EP14754054
申请日：2014-02-19
Applicant: NAT UNIV SINGAPORE
Inventor： HUANG ZHIWEI , BERGHOLT MADS SYLVEST , ZHENG WEI , HO KHEK YU
CPC classification number: A61B5/0075 , A61B1/00165 , A61B5/0084 , G01J3/0218 , G01J3/0272 , G01J3/18 , G01J3/28 , G01J3/44 , G01N21/65 , G01N2201/129 , G02B23/2469 , G02B23/26
Abstract: A diagnostic instrument comprises a monochromatic light source, transmission means to transmit light from the light source to a test site, collection means to transmit scattered light from the test site, and spectral analysis apparatus to receive light from the collection means, the spectral analysis apparatus comprising a diffraction grating having a first grating element and a second grating element, wherein the first grating element diffracts light within a first wavelength range and the second grating element diffracts light within a second wavelength range, the spectral analysis apparatus further comprising a light-sensing apparatus, the first grating element arranged to diffract light onto a first area of the light-sensing apparatus and the second grating element arranged to diffract light onto a second area of the light-sensing apparatus.
Abstract translation: 诊断仪器包括单色光源，将光从光源透射到测试部位的传输装置，用于传输来自测试部位的散射光的收集装置，以及用于从收集装置接收光的光谱分析装置，光谱分析装置 包括具有第一光栅元件和第二光栅元件的衍射光栅，其中所述第一光栅元件衍射第一波长范围内的光，所述第二光栅元件在第二波长范围内衍射光，所述光谱分析设备还包括光感测 装置，第一光栅元件被布置成将光衍射到光感测装置的第一区域上，第二光栅元件被布置成将光衍射到光感测装置的第二区域上。
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公开(公告)号：WO2010138083A1
公开(公告)日：2010-12-02
申请号：PCT/SG2010000200
申请日：2010-05-31
Applicant: UNIV NANYANG TECH , UNIV SINGAPORE , PHEE SOO JAY LOUIS , LOW SOON CHIANG , HO KHEK YU , CHUNG SHEUNG CHEE
Inventor： PHEE SOO JAY LOUIS , LOW SOON CHIANG , HO KHEK YU , CHUNG SHEUNG CHEE
CPC classification number: A61B19/2203 , A61B1/00147 , A61B18/14 , A61B34/30 , A61B34/37 , A61B34/77 , A61B2017/00278 , A61B2017/00292 , A61B2017/00296 , A61B2017/2906 , A61B2017/2929 , A61B2018/1422 , A61B2018/1495 , A61B2034/301 , A61B2090/064 , Y10S901/34
Abstract: A robotic manipulator (100), controller (300) and system for use in flexible endoscopy, the manipulator (100) comprising a flexible member configured to be coupled to an endoscope, and an arm connected to and movable by the flexible member, wherein the flexible member has a first end connected to the arm and a second end connectable to the controller (300) to allow a physical movement of the arm to be controllable by a physical movement of the controller (300).
Abstract translation: 一种用于柔性内窥镜检查的机器人操纵器（100），控制器（300）和系统，所述操纵器（100）包括构造成联接到内窥镜的柔性构件以及连接到柔性构件并可由所述柔性构件移动的臂 柔性构件具有连接到臂的第一端和可连接到控制器（300）的第二端，以允许臂的物理移动由控制器（300）的物理运动控制。
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公开(公告)号：SG10201508118WA
公开(公告)日：2015-11-27
申请号：SG10201508118W
申请日：2011-09-30
Applicant: AGENCY SCIENCE TECH & RES , MULTICLONAL THERAPEUTICS INC , BRIGHAM & WOMENS HOSPITAL , UNIV SINGAPORE , UNIV HARVARD
Inventor： XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
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公开(公告)号：WO2012044992A3
公开(公告)日：2012-06-14
申请号：PCT/US2011054323
申请日：2011-09-30
Applicant: AGENCY SCIENCE TECH & RES , MULTICLONAL THERAPEUTICS INC , BRIGHAM & WOMENS HOSPITAL , UNIV SINGAPORE , UNIV HARVARD , XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
Inventor： XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
IPC: G01N33/50 , C12N5/09 , G01N33/574
CPC classification number: C12N5/0695 , C12N5/068 , C12Q1/6886 , G01N33/5011 , G01N33/5073 , G01N33/57407 , G01N33/57446
Abstract: The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.
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Patent Agency Ranking6.发明申请METHODS AND REAGENTS FOR DETECTION AND TREATMENT OF ESOPHAGEAL METAPLASIA 审中-公开用于检测和治疗食管鳞状细胞癌的方法和试剂
公开(公告)号：WO2012044992A2
公开(公告)日：2012-04-05
申请号：PCT/US2011054323
申请日：2011-09-30
Applicant: AGENCY SCIENCE TECH & RES , MULTICLONAL THERAPEUTICS INC , BRIGHAM & WOMENS HOSPITAL , UNIV SINGAPORE , UNIV HARVARD , XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
Inventor： XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
IPC: G01N33/50 , C12N5/09 , G01N33/574
CPC classification number: C12N5/0695 , C12N5/068 , C12Q1/6886 , G01N33/5011 , G01N33/5073 , G01N33/57407 , G01N33/57446
Abstract: The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.
Abstract translation: 本文描述的发明涉及各种癌症的治疗，检测和诊断，包括食管癌或胃腺癌和相关的化生。 本发明还包括巴雷特食管祖细胞的克隆群体及其用于治疗，检测和诊断巴雷特食管的方法。
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公开(公告)号：EP2897543A4
公开(公告)日：2016-09-07
申请号：EP13838406
申请日：2013-09-19
Applicant: UNIV NANYANG TECH , UNIV SINGAPORE
Inventor： PHEE SOO JAY LOUIS , HUYHN VAN AN , WANG ZHENG , PENNY ISSAC DAVID , HO KHEK YU
IPC: A61B17/94 , A61B1/00 , A61B1/005 , A61B1/012 , A61B1/018 , A61B1/05 , A61B8/00 , A61B8/12 , A61B17/29 , A61B34/00 , A61B34/30 , A61B34/37
CPC classification number: A61B1/00098 , A61B1/00135 , A61B1/00183 , A61B1/0057 , A61B1/0125 , A61B1/018 , A61B8/12 , A61B8/4466 , A61B34/30 , A61B34/37 , A61B34/71 , A61B2017/2906 , A61B2034/303 , F04C2270/0421
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公开(公告)号：EP2434977A4
公开(公告)日：2014-01-01
申请号：EP10780898
申请日：2010-05-31
Applicant: UNIV NANYANG TECH , UNIV SINGAPORE
Inventor： PHEE SOO JAY LOUIS , LOW SOON CHIANG , HO KHEK YU , CHUNG SHEUNG CHEE
CPC classification number: A61B19/2203 , A61B1/00147 , A61B18/14 , A61B34/30 , A61B34/37 , A61B34/77 , A61B2017/00278 , A61B2017/00292 , A61B2017/00296 , A61B2017/2906 , A61B2017/2929 , A61B2018/1422 , A61B2018/1495 , A61B2034/301 , A61B2090/064 , Y10S901/34
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公开(公告)号：CA2917308C
公开(公告)日：2021-07-13
申请号：CA2917308
申请日：2013-07-02
Applicant: NAT UNIV SINGAPORE
Inventor： HUANG ZHIWEI , HO KHEK YU , BERGHOLT MADS SYLVEST , ZHENG WEI , YEOH KHAY GUAN , DURAIPANDIAN SHIYAMALA
IPC: G01N21/65 , A61B5/00 , A61B6/00 , G01J3/44 , G01N33/574
Abstract: A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.
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公开(公告)号：GB2513343A
公开(公告)日：2014-10-29
申请号：GB201307338
申请日：2013-04-23
Applicant: UNIV SINGAPORE
Inventor： HUANG ZHIWEI , BERGHOLT MADS SYLVEST , ZHENG WEI , HO KHEK YU , YEOH KHAY GUAN , DURAPAIPANDIAN SHIYAMALA
Abstract: A method of calibrating a fibre-optic Raman spectroscope system 20 comprising a laser source 21, a spectroscope 30 and a fibre-optic probe 11 to transmit light from the laser source to a target and return scattered light to the spectroscope, comprises transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration spectrum and generating a transfer function, and storing the transfer function. The transfer function is then used on further spectral measurements using the spectroscope system. A method of estimating laser power in the system and a method of subtracting a background signal from a Raman spectrum is also disclosed.
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