公开(公告)号：WO2017091598A1

公开(公告)日：2017-06-01

申请号：PCT/US2016/063382

申请日：2016-11-22

Applicant: LIGHTLAB IMAGING, INC.

Inventor： GRIFFIN, Christopher E.

IPC: G06T7/00 ,  G06T7/136

CPC classification number: G06T7/0012 ,  A61B5/0066 ,  A61B5/0082 ,  A61B8/0891 ,  A61B8/12 ,  G06T7/0085 ,  G06T7/136 ,  G06T2207/10101 ,  G06T2207/10136 ,  G06T2207/20012 ,  G06T2207/20148 ,  G06T2207/30101

Abstract: In part, the disclosure relates to shadow detection and shadow validation relative to data sets obtained from an intravascular imaging data collection session. The methods can use locally adaptive thresholds and scan line level analysis relative to candidate shadow regions to determine a set of candidate shadows for validation or rejection. In one embodiment, the shadows are stent strut shadows, guidewire shadows, side branch shadows or other shadows.

Abstract translation: 部分地，本公开涉及相对于从血管内成像数据收集会话获得的数据组的阴影检测和阴影验证。 这些方法可以使用相对于候选阴影区域的局部自适应阈值和扫描线水平分析来确定用于验证或拒绝的一组候选阴影。 在一个实施例中，阴影是支架支柱阴影，导线阴影，侧分支阴影或其他阴影。

公开(公告)号：WO2017087450A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062161

申请日：2016-11-16

Applicant: LIGHTLAB IMAGING, INC.

Inventor： PETERSON, James G. ,  GRIFFIN, Christopher E. ,  AMBWANI, Sonal

IPC: A61B5/00

CPC classification number: A61B8/12 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/061 ,  A61B5/6852 ,  A61B90/36 ,  G06T2207/10101 ,  G06T2207/30021

Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for detecting a delivery catheter using intravascular data. In one embodiment, the delivery catheter is used to position the intravascular data collection probe. The probe can collect data suitable for generating one or more representations of a blood vessel with respect to which the delivery catheter can be detected.

Abstract translation: 部分地，本公开涉及适用于使用血管内数据检测输送导管的基于计算机的方法，装置和系统。 在一个实施例中，输送导管用于定位血管内数据收集探针。 探针可以收集适合于产生血管的一个或多个表征的数据，关于该血管可以检测输送导管。

公开(公告)号：WO2017019626A1

公开(公告)日：2017-02-02

申请号：PCT/US2016/043912

申请日：2016-07-25

Applicant: LIGHTLAB IMAGING, INC.

Inventor： GRIFFIN, Christopher E. ,  AMBWANI, Sonal ,  KAVETI, Satish

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/06

CPC classification number: G06T11/003 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/065 ,  A61B5/6852 ,  A61B5/7217 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/5223 ,  A61M25/09 ,  G06T7/0012 ,  G06T7/194 ,  G06T7/70 ,  G06T2207/10068 ,  G06T2207/10101 ,  G06T2207/30101

Abstract: In part, the disclosure relates to methods of guidewire detection in intravascular data sets such as scan lines, frames, images and combinations thereof. Methods of generating one or more indicia of a guidewire in a representation of blood vessel are also features of the disclosure. A carpet view is generated in one embodiment and regions of relatively higher contrast are detected as candidate guidewire regions. In one embodiment, the disclosure relates to selective removal of guidewire segments from a set of intravascular data and the display of a representation of a blood vessel via a user interface. Representations of a guidewire can be toggled on and off in one embodiment.

Abstract translation: 部分地，本公开涉及血管内数据集（例如扫描线，帧，图像及其组合）中的导丝检测方法。 在血管表示中产生导丝的一个或多个标记的方法也是本公开的特征。 在一个实施例中产生地毯视图，并且检测相对较高对比度的区域作为候选导丝区域。 在一个实施例中，本公开涉及从一组血管内数据中选择性地移除导丝段并经由用户界面显示血管的表示。 在一个实施例中，导丝的表示可以被打开和关闭。

公开(公告)号：WO2014092755A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/030328

申请日：2013-03-12

Applicant: LIGHTLAB IMAGING, INC.

Inventor： SCHMITT, Joseph, M ,  BEZERRA, Hiram ,  PETROFF, Christopher ,  GOPINATH, Ajay

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/107

CPC classification number: A61F2/86 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/1076 ,  A61B2090/061 ,  A61F2/82 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/006 ,  G06F19/00 ,  G06F19/321

Abstract: In part, the invention relates to a method for sizing a stent for placement in a vessel. In one embodiment, the method includes the steps of: dividing the vessel into a plurality of segments, each segment being defined as the space between branches of the vessel; selecting a starting point that appears to have substantially no disease; defining the diameter at this point to be the maximum diameter; calculating the maximal diameter of the next adjacent segment according to a power law; measuring the actual diameter of the next adjacent segment; selecting either the calculated maximum diameter or the measured maximum diameter depending upon which diameter is larger; using the selected maximum diameter to find the maximum diameter of this next segment; iteratively proceeding until the entire length of the vessel is examined; and selecting a stent in response to the diameters of the end proximal and distal segments.

Abstract translation: 部分地，本发明涉及一种用于定位用于放置在容器中的支架的尺寸的方法。 在一个实施例中，该方法包括以下步骤：将容器分成多个段，每个段被定义为容器的分支之间的空间; 选择似乎没有疾病的起点; 此时将直径定义为最大直径; 根据幂律计算下一相邻段的最大直径; 测量下一个相邻段的实际直径; 选择计算的最大直径或测量的最大直径取决于哪个直径较大; 使用所选择的最大直径来找到该下一段的最大直径; 反复进行，直到检查船舶的整个长度; 以及响应于末端近端和远端段的直径选择支架。

公开(公告)号：WO2014077871A3

公开(公告)日：2014-05-22

申请号：PCT/US2013/024628

申请日：2013-02-04

Applicant: LIGHTLAB IMAGING, INC.

Inventor： HUTCHINS, Christopher ,  ATLAS, Michael ,  SHIP, Alexander

IPC: A61B8/12

Abstract: In one aspect, the invention relates to one or more rotatable elements and one or more stationary element such that the elements are arranged along a common axis of rotation co- linear with or substantially parallel to an optical path. The optical path is a portion of a sample arm of an interferometer. Further, the rotatable and stationary elements are configured to couple electrical signals and optical signals between a data collection probe and an interface unit or other component of an imaging system. In one embodiment, the data collection probe is a combination ultrasound and OCT probe. In one aspect, the invention relates to a rotary joint in which the optical fiber and a fiber optic rotary joint lie in the center of one or more conductive elements of an electrical rotary joint which are annularly disposed around one or both of the optical fiber and optical rotary joint.

公开(公告)号：WO2014077871A2

公开(公告)日：2014-05-22

申请号：PCT/US2013024628

申请日：2013-02-04

Applicant: LIGHTLAB IMAGING INC

Inventor： HUTCHINS CHRISTOPHER ,  ATLAS MICHAEL ,  SHIP ALEXANDER

IPC: A61B8/00

CPC classification number: A61B8/4416 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B8/12 ,  A61B2562/0204 ,  A61B2562/0233

Abstract: In one aspect, the invention relates to one or more rotatable elements and one or more stationary element such that the elements are arranged along a common axis of rotation co- linear with or substantially parallel to an optical path. The optical path is a portion of a sample arm of an interferometer. Further, the rotatable and stationary elements are configured to couple electrical signals and optical signals between a data collection probe and an interface unit or other component of an imaging system. In one embodiment, the data collection probe is a combination ultrasound and OCT probe. In one aspect, the invention relates to a rotary joint in which the optical fiber and a fiber optic rotary joint lie in the center of one or more conductive elements of an electrical rotary joint which are annularly disposed around one or both of the optical fiber and optical rotary joint.

Abstract translation: 在一个方面，本发明涉及一个或多个可旋转元件和一个或多个固定元件，使得元件沿着与光路共线或基本上平行的共同旋转轴线布置。 光路是干涉仪的样品臂的一部分。 此外，可旋转和固定元件被配置为在数据采集探针与成像系统的接口单元或其他部件之间耦合电信号和光信号。 在一个实施例中，数据采集探针是组合超声和OCT探针。 一方面，本发明涉及一种旋转接头，其中光纤和光纤旋转接头位于电旋转接头的一个或多个导电元件的中心，环形设置在光纤和 光学旋转接头。

公开(公告)号：WO2013003267A1

公开(公告)日：2013-01-03

申请号：PCT/US2012/043969

申请日：2012-06-25

Applicant: LIGHTLAB IMAGING, INC. ,  DOUK, Nareak ,  BRUSHETT, Christopher ,  MCCARTIN, Stephen, M. ,  MIZOGUCHI, Hirofumi ,  PETERSEN, Christopher ,  PETROFF, Christopher

Inventor： DOUK, Nareak ,  BRUSHETT, Christopher ,  MCCARTIN, Stephen, M. ,  MIZOGUCHI, Hirofumi ,  PETERSEN, Christopher ,  PETROFF, Christopher

IPC: A61M25/00

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61M25/0015 ,  A61M25/003 ,  A61M25/09 ,  A61M2025/0183 ,  Y10T29/49826

Abstract: In part, the invention relates to a catheter suitable for flushing a vessel. The catheter can include separated lumens and components that improve image data collection. In one embodiment, the catheter includes a catheter wall; a distal portion defining a distal lumen (62), the distal lumen having a first end terminating at the distal end of the catheter and a second end (30) terminating at an exit port in the catheter wall; a proximal portion defining proximal lumen (42), the proximal lumen having a first end terminating at the proximal end of the catheter and a second end terminating at a vent port (34) in the catheter wall; and a valve (50,54) positioned adjacent the vent port, the valve permitting fluid to exit the proximal lumen, but preventing particulate matter from the environment from entering the proximal lumen. In one embodiment, the valve comprises a piston (50) and spring (54) located in the proximal lumen (42). In another embodiment, the valve is a filter located in the proximal lumen adjacent the vent port.

Abstract translation: 部分地，本发明涉及适于冲洗血管的导管。 导管可以包括分离的腔和组件，其改善图像数据采集。 在一个实施例中，导管包括导管壁; 限定远端内腔（62）的远侧部分，远端腔具有终止于导管远端的第一端和终止于导管壁中的出口处的第二端（30）; 限定近端内腔（42）的近端部分，所述近端内腔具有终止于所述导管近端的第一端和终止于所述导管壁中的通气口（34）的第二端; 以及邻近所述通气口定位的阀门（50,54），所述阀允许流体离开所述近端内腔，但防止来自所述环境的颗粒物质进入所述近端内腔。 在一个实施例中，阀包括位于近端内腔（42）中的活塞（50）和弹簧（54）。 在另一个实施例中，阀是位于邻近排气口的近端腔内的过滤器。

公开(公告)号：WO2011090744A2

公开(公告)日：2011-07-28

申请号：PCT/US2010/062330

申请日：2010-12-29

Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M. ,  PETROFF, Christopher

Inventor： SCHMITT, Joseph, M. ,  PETROFF, Christopher

IPC: A61B5/00 ,  A61B5/0215

CPC classification number: A61B5/02154 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/6852 ,  A61B5/742

Abstract: An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.

Abstract translation: 光学相干断层扫描系统和集成压力测量方法。 在一个实施例中，系统包括干涉仪，包括：波长扫描激光; 与波长扫描激光器通信的源臂; 与参考反射器连通的参考臂; 具有信号输出的第一光电检测器; 与第一光电检测器连通的检测器臂，探针接口; 与所述探针接口的第一光学连接器连通的样品臂; 一种采集和显示系统，包括：具有与第一光电检测器信号输出通信的信号输入的信号输出的A / D转换器; 与A / D转换器信号输出通信的处理器系统; 以及与处理器系统通信的显示器; 以及探针，其包括压力传感器并且被配置为连接到所述探针接口的所述第一光学连接器，其中所述压力传感器包括光学压力传感器。

公开(公告)号：WO2009149131A1

公开(公告)日：2009-12-10

申请号：PCT/US2009/046035

申请日：2009-06-02

Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M. ,  XU, Chenyang

Inventor： SCHMITT, Joseph, M. ,  XU, Chenyang

IPC: A61B5/00 ,  G01N21/47

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/7264

Abstract: A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.

Abstract translation: 用于确定通过光学相干断层摄影（OCT）成像的组织或组织的性质的方法和装置。 在一个实施例中，测量OCT光束的后向散射和衰减，并且基于这些测量，并且针对对应于该部分的后向散射和衰减的特定值的图像的每个部分分配诸如颜色的标记。 然后用标记显示图像，然后用户可以确定组织特征。 在替代实施例中，通过给出反向散射和衰减值的组合的程序，组织特征被自动分类。

公开(公告)号：WO2008086017A1

公开(公告)日：2008-07-17

申请号：PCT/US2008/000341

申请日：2008-01-10

Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M.

Inventor： SCHMITT, Joseph, M.

IPC: A61B5/00 ,  G01B9/02

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02004 ,  G01B9/02043 ,  G01B9/02069 ,  G01B2290/25 ,  G01B2290/60 ,  H01S3/1062 ,  H01S5/141 ,  H01S5/146 ,  H01S5/5036

Abstract: In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.

Abstract translation: 在本发明的一个实施例中，选择激光环中的半导体光放大器（SOA）以提供低偏振相关增益（PDG），并且选择在环外部的升压半导体光放大器以提供高偏振相关 获得。 使用具有低偏振相关增益的半导体光放大器几乎消除了在激光器的输出处的光的偏振状态的变化，但是不消除激光器的输出处的偏振状态的扫描内变化， 这可能会降低SS-OCT系统的性能。