公开(公告)号：US20030169638A1

公开(公告)日：2003-09-11

申请号：US10408812

申请日：2003-04-08

Applicant: Symyx Technologies, Inc.

Inventor： Ralph B. Nielsen

IPC: B01F007/00

CPC classification number: B01F13/1022 ,  B01F7/00033 ,  B01F7/0015 ,  B01F7/002 ,  B01F7/18 ,  B01F13/1013 ,  B01J2219/00283 ,  B01J2219/00306 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14

Abstract: Method and apparatus for mixing small volumes of reaction components. In one application, a plurality of removable vessels are placed in a parallel reactor, and reaction components are delivered to each vessel. An impeller is rotated in each vessel to mix the components. Each impeller has a rotary shaft and at least one blade on the shaft for placement in the reaction components. The blade is dimensioned so that one rotation of the impeller causes the blade to sweep out a sweep volume representing a large amount of the fill volume of the vessel.

Abstract translation: 用于混合少量反应组分的方法和装置。 在一个应用中，将多个可移除的容器放置在平行的反应器中，并将反应组分输送到每个容器。 在每个容器中旋转叶轮以混合组分。 每个叶轮具有旋转轴和轴上的至少一个叶片，用于放置在反应部件中。 叶片的尺寸被设计成使得叶轮的一个旋转使叶片扫出表示容器的大量填充体积的扫掠体积。

公开(公告)号：US20030125484A1

公开(公告)日：2003-07-03

申请号：US10315512

申请日：2002-12-09

Applicant: Symyx Technologies, Inc.

Inventor： J. Christopher Freitag ,  Damian Hajduk ,  Ralph B. Nielsen ,  Adam Safir ,  Richard Tiede

IPC: C08F002/00

CPC classification number: B01J19/0046 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  Y10S526/92 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A method and apparatus for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel, the reactor vessels combined into a reactor block. Reactant(s) to be added during the reaction are kept in a header barrel, which has a plunger to feed reactant(s) from the header barrel through a transfer line into the reactor vessel. The plunger is moved using a drive system. The header barrels are optionally combined in a header block. The header block is sealed to a plate containing the transfer lines, which in turn is sealed to the reactor block. A latch mechanism is provided for easy sealing of the reactor and header blocks to the plate. The entire apparatus may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.

Abstract translation: 提供了以半批或连续模式并行地进行多种不同混合物的方法和装置。 每个反应都包含在反应器容器中，反应器容器组合成反应器块。 在反应过程中加入的反应物保持在集管筒中，其具有柱塞，以通过输送管将反应物从集管筒送入反应器容器。 柱塞使用驱动系统移动。 标题桶可选地组合在标题块中。 集管块被密封到含有输送管线的板上，转移管路又与反应器块密封。 提供了一种闭锁机构，用于容易地将反应堆和集管块密封到板上。 当反应进行时，整个装置可以放置在摇臂或旋转板上用于混合。

公开(公告)号：US20030100119A1

公开(公告)日：2003-05-29

申请号：US10269362

申请日：2002-10-11

Applicant: Symyx Technologies, Inc.

Inventor： W. Henry Weinberg ,  Eric McFarland ,  Isy Goldwasser ,  Thomas Boussie ,  Howard Turner ,  Johannes A.M. Van Beek ,  Vince Murphy ,  Tim Powers

IPC: G01N001/10

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

Abstract translation: 本发明尤其涉及有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法。 本发明的方法提供了负载和未负载的有机金属化合物和催化剂（例如均相催化剂）的文库的组合合成，筛选和表征。 本发明的方法可用于大量有机金属化合物的制备和筛选，所述有机金属化合物不仅可用作催化剂（例如均相催化剂），而且可用作添加剂和治疗剂。

公开(公告)号：US20020155036A1

公开(公告)日：2002-10-24

申请号：US10134556

申请日：2002-04-29

Applicant: Symyx Technologies, Inc.

Inventor： Damian A. Hajduk ,  Ralph B. Nielsen ,  Adam Safir ,  Leonid Matsiev ,  Eric McFarland ,  Paul Mansky

IPC: B01J019/00

CPC classification number: B01F15/00207 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00357 ,  B01F15/00396 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28D15/00 ,  F28D2021/0077 ,  F28F27/00 ,  G01K13/00 ,  G01N21/253 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/25

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

Abstract translation: 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的​​装置。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。

公开(公告)号：US20020137845A1

公开(公告)日：2002-09-26

申请号：US09992760

申请日：2001-11-06

Applicant: Symyx Technologies, Inc.

Inventor： Thomas R. Boussie ,  Gary M. Diamond ,  Christopher Goh ,  Keith A. Hall ,  Anne M. LaPointe ,  Margarete K. Leclerc ,  Cheryl Lund ,  Vince Murphy

IPC: C08F004/44

CPC classification number: C07D213/74 ,  B01J2219/00722 ,  C07B2200/11 ,  C07D213/38 ,  C07D213/61 ,  C07D213/68 ,  C07F7/00 ,  C07F7/003 ,  C07F9/58 ,  C08F4/65908 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/06 ,  C08F210/02 ,  C08F210/16 ,  C40B40/14 ,  C08F4/659 ,  C08F4/65904 ,  C08F2500/15 ,  C08F2500/02 ,  C08F210/10 ,  C08F212/08 ,  C08F210/14 ,  C08F4/64144 ,  C08F4/64113 ,  C08F4/64044

Abstract: New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions.

Abstract translation: 公开了新配体，组合物，金属 - 配体络合物和具有吡啶基 - 胺配体的阵列，其催化单体聚合成聚合物。 这些具有铪金属中心的这些催化剂中的某些具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，异丁烯或苯乙烯。 某些催化剂在各种聚合条件下在溶液过程中将丙烯聚合成高分子量全同立构聚丙烯是特别有效的。

公开(公告)号：US20020127146A1

公开(公告)日：2002-09-12

申请号：US10092364

申请日：2002-03-06

Applicant: Symyx Technologies, Inc.

Inventor： H. Sam Bergh ,  Daniel M. Pinkas

IPC: B01J019/00 ,  G01N030/02 ,  B01L003/00

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K7/14 ,  F16K27/003 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N30/20 ,  G01N2030/205 ,  Y10T436/2575

Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.

Abstract translation: 提供了一种用于将离散的气体注入流动相或载流子的新颖的气体注入阀。 本发明的注射阀包括能够接收不同压力的气体并以大致相同的压力发射离散的气体的多个微型阀。 本发明还提供了能够基本上同时喷射多个样品的平行喷射阀阵列以及将受控压力的离散气体样品注入高分辨率气相色谱仪的方法。

公开(公告)号：US20020110493A1

公开(公告)日：2002-08-15

申请号：US10040988

申请日：2002-01-07

Applicant: Symyx Technologies , Inc

Inventor： G. Cameron Dales ,  Gary Diamond ,  Trevor G. Frank ,  J. Christopher Freitag ,  Kenneth S. Higashihara ,  Dave Huffman ,  Jonah R. Troth

IPC: B01L003/02

CPC classification number: B01F7/167 ,  B01F7/00258 ,  B01F7/00266 ,  B01F7/00291 ,  B01F7/00416 ,  B01F7/00575 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F2215/0037 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00342 ,  B01J2219/00351 ,  B01J2219/00353 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00466 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/2226 ,  G01N21/253 ,  G01N35/0099 ,  G01N35/1004 ,  G01N35/1079 ,  G01N2035/00514 ,  G01N2035/0406 ,  Y10T436/2575

Abstract: A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition.

Abstract translation: 用于转移少量流体材料的插管，例如在平行的反应过程中。 套管包括具有各种端部（端口）构造的长细针，以及用于将针连接到流体管线的适配器。 适配器可以包括储存器和转换器的组合，或简单地转换。

公开(公告)号：US20010033375A1

公开(公告)日：2001-10-25

申请号：US09874758

申请日：2001-06-05

Applicant: Symyx Technologies, Inc.

Inventor： Eric W. McFarland ,  Earl Danielson ,  William Archibald

IPC: G01N021/21

CPC classification number: G01N21/6402 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01J4/00 ,  G01N21/6452 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/348 ,  G01N29/4427 ,  G01N2291/106 ,  C08F4/70

Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials.

Abstract translation: 提供了筛选各种材料阵列的方法和装置。 特别地，提供了用于快速表征材料阵列中的化合物以发现和/或优化具有特定期望性质的新材料的技术。 对于具有有用性质的材料，可以对基材进行筛选，和/或可以对所得到的材料进行相对于有用性质或其它特性的相对性能的评价或以其它方式比较。 特别地，提供了系统和方法，用于通过对其单独的光学克尔旋转进行成像来筛选磁性材料库的体积磁化，饱和磁化强度和矫顽力，通过对其介电系数进行成像来筛选介电材料库， 通过在各种激发条件下成像其各自的发光性质来旋转和筛选发光材料库。 还提供光学或可见发光系统以及其应用于筛选不同材料的文库。

公开(公告)号：CA2562090C

公开(公告)日：2014-12-02

申请号：CA2562090

申请日：2005-04-28

Applicant: SYMYX TECHNOLOGIES INC

Inventor： BOUSSIE THOMAS R ,  BRUEMMER OLIVER ,  DIAMOND GARY M ,  LAPOINTE ANNE M ,  LECLERC MARGARETE K ,  MICKLATCHER CYNTHIA ,  SUN PU ,  BEI XIAOHONG

IPC: C07F7/00 ,  C07F5/00 ,  C07F9/00 ,  C07F11/00 ,  C08F4/659 ,  C08F10/00 ,  C08F110/06 ,  C08F210/16

Abstract: Ligands, compositions, metal-ligand complexes and arrays with substituted bridged bis-biaromatic ligands and method of making and using the same, are disclosed that are useful in the catalysis of transformations such as the polymerization of monomers into polymers. The catalysts have high performance characteristics, including higher comonomer incorporation into ethylene ethylene/olefin copolymers, where such olefins are for example, 1-ocetene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.

公开(公告)号：DE60044254D1

公开(公告)日：2010-06-02

申请号：DE60044254

申请日：2000-06-19

Applicant: AGFA HEALTHCARE NV ,  SYMYX TECHNOLOGIES INC

Inventor： DEVENNEY MARTIN ,  REAVES CASPER ,  LEBLANS PAUL ,  STRUYE LUC

IPC: G01J3/443 ,  H01J9/22 ,  A61B6/00 ,  C01F17/00 ,  C09K3/00 ,  C09K11/00 ,  C09K11/08 ,  C09K11/55 ,  C09K11/61 ,  C09K11/85 ,  C23C14/06 ,  C23C16/30 ,  G01N23/04 ,  G01T1/00 ,  G01T1/105 ,  G01T1/202 ,  G01T1/29 ,  G01T7/00 ,  G03B42/02 ,  G03B42/08 ,  G03C5/16 ,  G06T1/00 ,  G11B7/135 ,  G21K4/00 ,  H01L31/09 ,  H04N1/04 ,  H04N1/113

Abstract: A CsX:Eu phosphor produced by heating a cesium halide with a Europium compound containing one or more halides selected from the group consisting of F, Cl, Br and I. Preferably the Europium compound is selected from the group consisting of EuX'2, and EuX'3 and EuX', X' being one or more halides selected from the group consisting of F, Cl, Br and I. The invention also includes novel phosphors having properties inherent to the manufacturing process as well as other phosphors containing a mixture of Br and Cl in the cesium halide, europium doped phosphor.A method for preparing a binderless phosphor screen using these phosphors and a method for recording and reproducing an X-ray image using such screens are also disclosed.