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    ENANTIOSELECTIVE SYNTHESIS OF SULFONAMIDE INTERMEDIATES
    95.
    发明申请
    ENANTIOSELECTIVE SYNTHESIS OF SULFONAMIDE INTERMEDIATES 审中-公开
    磺酰胺中间体的选择性合成

    公开(公告)号：WO1996010573A1

    公开(公告)日：1996-04-11

    申请号：PCT/US1995011317

    申请日：1995-09-07

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  HOFF, Roman

    IPC: C07D513/04

    CPC classification number: C07D513/04

    Abstract: Enantioselective syntheses of (S)-6-chloro-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazin-4-ol 1,1-dioxide and related compounds of the formula (1) wherein R is H or Cl; and R' is C1-6 alkyl, CH2(CH2)nOR", wherein R" is CH3 or (CH2)nCH3 and n is 1-4, CH2(CH2)nX, wherein X is Br, Cl, or I, and n is 1-4, or (CH2)nAr, wherein Ar is unsubstituted phenyl, 3-methoxyphenyl, or 4-methoxyphenyl and n is 1 or 2.

    Abstract translation: （S）-6-氯-3,4-二氢-2-（3-甲氧基丙基）-2H-噻吩并[3,2-e] -1,2-噻嗪-4-醇1,1-二氧化物的对映选择性合成 和式（1）的相关化合物，其中R是H或Cl; 和R'是C 1-6烷基，CH 2（CH 2）nOR“，其中R”是CH 3或（CH 2）n CH 3，n是1-4，CH 2（CH 2）n X，其中X是Br，Cl或I， n为1-4或（CH2）nAr，其中Ar为未取代的苯基，3-甲氧基苯基或4-甲氧基苯基，n为1或2。

    USE OF LOW MOLECULAR WEIGHT AMINO ACIDS IN OPHTHALMIC COMPOSITIONS
    96.
    发明申请
    USE OF LOW MOLECULAR WEIGHT AMINO ACIDS IN OPHTHALMIC COMPOSITIONS 审中-公开
    低分子量氨基酸在眼科组合物中的应用

    公开(公告)号：WO1996003158A1

    公开(公告)日：1996-02-08

    申请号：PCT/US1995008937

    申请日：1995-07-17

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  CHOWHAN, Masood ,  ASGHARIAN, Bahram ,  STACH, Paul

    IPC: A61L02/18

    CPC classification number: A61L12/14 ,  A01N37/44 ,  Y10S514/912

    Abstract: The use of glycine and other low molecular weight amino acids in ophthalmic compositions (e.g., preserved saline solutions) is described. These compounds have been found to enhance the efficacy of antimicrobial preservatives. The compounds also act as chelating agents, buffers and tonicity agents.

    Abstract translation: 描述了在眼科组合物（例如，保存的盐水溶液）中使用甘氨酸和其它低分子量氨基酸。 已经发现这些化合物增强了抗微生物防腐剂的功效。 所述化合物还用作螯合剂，缓冲剂和张度剂。

    IMPROVED SYSTEM FOR DISINFECTING CONTACT LENSES WITH HYDROGEN PEROXIDE
    97.
    发明申请
    IMPROVED SYSTEM FOR DISINFECTING CONTACT LENSES WITH HYDROGEN PEROXIDE 审中-公开
    改善用过氧化氢消毒接触镜的系统

    公开(公告)号：WO1996003157A1

    公开(公告)日：1996-02-08

    申请号：PCT/US1995008929

    申请日：1995-07-17

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  CHOWHAN, Masood ,  GAUTAM, Jaya

    IPC: A61L02/18

    CPC classification number: A61L12/124 ,  A61L12/126

    Abstract: Systems and methods for disinfecting contact lenses with hydrogen peroxide solutions are described. The systems and methods are based on the use of an improved means for neutralizing the hydrogen peroxide following disinfection of the lenses. The neutralization component of the present invention includes a hydrogen peroxide neutralizing agent, boric acid and glycine. The neutralization component provides antimicrobial activity sufficient to prevent the lenses from being recontaminated with bacteria or other microbes during the neutralization step.

    Abstract translation: 描述了用过氧化氢溶液消毒隐形眼镜的系统和方法。 该系统和方法基于在消除镜片消毒后使用改进的中和过氧化氢的方法。 本发明的中和成分包括过氧化氢中和剂，硼酸和甘氨酸。 中和组分提供足够的抗微生物活性，以防止在中和步骤期间透镜与细菌或其他微生物再次被分解。

    NOVEL PROCESS FOR PREPARATION OF CLONIDINE DERIVATIVES
    99.
    发明申请
    NOVEL PROCESS FOR PREPARATION OF CLONIDINE DERIVATIVES 审中-公开
    制备CLONIDINE衍生物的新方法

    公开(公告)号：WO1995021818A1

    公开(公告)日：1995-08-17

    申请号：PCT/US1995001641

    申请日：1995-02-07

    Applicant: ALCON LABORATORIES, INC. ,  PIERCE, David, R. ,  DEAN, William, D. ,  DEASON, Michael, E.

    Inventor： ALCON LABORATORIES, INC.

    IPC: C07C335/16

    CPC classification number: C07D239/14 ,  C07C335/16 ,  C07D233/50 ,  C07D243/04

    Abstract: A novel process preparing clonidine derivatives has been discovered which is shorter, less expensive and safer than previously known methods. A new thiourea complex of formula (I) wherein: Ar is a phenyl or naphthyl and unsubstituted or substituted with one or more moieties selected from the group consisting of: Cl, F, Br, I, C1 to C4 alkyl, aryl, C1 to C4 alkoxy or arylalkoxy; NO2 is in the para or ortho position; and n is 1 to 4, has also been discovered which can be directly cyclized to produce the corresponding heterocyclic product.

    Abstract translation: 已经发现制备可乐定衍生物的新方法比以前已知的方法更短，更便宜和更安全。 式（I）的新的硫脲配合物，其中：Ar是苯基或萘基，未取代或被一个或多个选自以下的部分取代：Cl，F，Br，I，C 1至C 4烷基，芳基，C 1至 C4烷氧基或芳基烷氧基; NO2位于对位或邻位; 并且n是1至4，也被发现可以直接环化以产生相应的杂环产物。

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