公开(公告)号：WO1997018288A1

公开(公告)日：1997-05-22

申请号：PCT/US1996016050

申请日：1996-10-07

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  ASGHARIAN, Bahram ,  HONG, Bor-Shyue ,  QUINTANA, Ronald, P.

IPC: C11D03/386

CPC classification number: C11D3/0078 ,  A61L12/145 ,  C11D3/386

Abstract: Compositions containing an ophthalmically acceptable, modified enzyme exhibiting a low pI and methods involving the combined use of these compositions with a polymeric antimicrobial agent, are disclosed for the simultaneous cleaning and disinfecting of contact lens.

Abstract translation: 公开了组合物，其包含显示低pI的眼科可接受的修饰酶和涉及将这些组合物与聚合抗微生物剂组合使用的方法，用于同时进行隐形眼镜的清洁和消毒。

公开(公告)号：WO1994025426A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004428

申请日：1994-04-22

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DASSANAYAKE, Nissanke, L. ,  SCHLITZER, Ronald, L. ,  PARK, Joonsup ,  ASGHARIAN, Bahram

IPC: C07C211/10

CPC classification number: C07C211/25 ,  A01N33/04 ,  A01N33/08 ,  A61L12/14 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C211/21 ,  C07C215/14 ,  Y10S514/839 ,  Y10S514/84

Abstract: Certain N,N-dialkyl, N'-alkylethylene diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

Abstract translation: 描述了某些N，N-二烷基，N'-烷基乙烯二胺，其用于消毒和清洁隐形眼镜和保存眼用产品以及相关眼用组合物。

公开(公告)号：WO1998022567A1

公开(公告)日：1998-05-28

申请号：PCT/US1997020057

申请日：1997-11-03

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  VAN DUZEE, Barry, F. ,  STONE, Ralph, P. ,  ASGHARIAN, Bahram

IPC: C11D03/386

CPC classification number: C11D3/38663 ,  A61L12/142 ,  A61L12/145 ,  C11D3/0078

Abstract: Compositions containing an ophthalmically acceptable enzyme of high purity and integrity in a liquid medium and methods involving the use of these compositions for cleaning a contact lens, and in combination with an anti-microbial agent for the simultaneous cleaning and disinfecting of contact lens are disclosed.

Abstract translation: 公开了含有液体介质中高纯度和完整性的眼科可接受的酶的组合物和涉及使用这些组合物来清洁隐形眼镜的方法，以及与用于同时清洁和消毒隐形眼镜的抗微生物剂组合。

公开(公告)号：WO1996003484A1

公开(公告)日：1996-02-08

申请号：PCT/US1995008939

申请日：1995-07-17

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  ASGHARIAN, Bahram ,  CHOWHAN, Masood ,  STACH, Paul

IPC: C11D03/00

CPC classification number: C11D3/48 ,  A61L12/14 ,  C11D1/04 ,  C11D1/72 ,  C11D1/83 ,  C11D3/0078 ,  C11D3/046 ,  C11D3/2065 ,  C11D3/33 ,  Y10S514/839 ,  Y10S514/912 ,  Y10S514/915

Abstract: Improved saline solutions useful in treating contact lenses are described. Unlike prior saline solutions used for similar purposes, the present solutions do not contain conventional antimicrobial agents which are potentially toxic to ocular tissues. Rather, the solutions contain a combinaison of a borate-polyol complex, one or more anionic or nonionic surfactants, and a low molecular weight amino acid (e.g., glycine). It has been found that this combination effectively preserves the saline solutions from antimicrobial contamination, is relatively nontoxic to ocular tissues, and is compatible with oxidizing agents used in certain contact lens disinfecting systems. The combination also facilitates the cleaning of contact lenses.

Abstract translation: 描述了用于治疗隐形眼镜的改进的盐水溶液。 不同于用于类似目的的先前的盐溶液，本溶液不含有对眼组织有潜在毒性的常规抗微生物剂。 相反，溶液含有硼酸盐 - 多元醇配合物，一种或多种阴离子或非离子表面活性剂和低分子量氨基酸（例如甘氨酸）的组合。 已经发现，这种组合有效地保留了抗菌污染的盐溶液，对眼组织相对无毒，并且与某些隐形眼镜消毒系统中使用的氧化剂相容。 该组合也有助于隐形眼镜的清洁。

公开(公告)号：WO1996003158A1

公开(公告)日：1996-02-08

申请号：PCT/US1995008937

申请日：1995-07-17

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CHOWHAN, Masood ,  ASGHARIAN, Bahram ,  STACH, Paul

IPC: A61L02/18

CPC classification number: A61L12/14 ,  A01N37/44 ,  Y10S514/912

Abstract: The use of glycine and other low molecular weight amino acids in ophthalmic compositions (e.g., preserved saline solutions) is described. These compounds have been found to enhance the efficacy of antimicrobial preservatives. The compounds also act as chelating agents, buffers and tonicity agents.

Abstract translation: 描述了在眼科组合物（例如，保存的盐水溶液）中使用甘氨酸和其它低分子量氨基酸。 已经发现这些化合物增强了抗微生物防腐剂的功效。 所述化合物还用作螯合剂，缓冲剂和张度剂。

公开(公告)号：EP0948357B1

公开(公告)日：2002-06-12

申请号：EP97947519.1

申请日：1997-11-17

Applicant: ALCON LABORATORIES, INC.

Inventor： ASGHARIAN, Bahram

IPC: A61K47/18 ,  A61L2/18 ,  G02C13/00

CPC classification number: A61K33/22 ,  A61K9/0048 ,  A61K31/13 ,  A61K31/138 ,  A61K47/18 ,  A61L12/147 ,  Y10S514/839 ,  Y10S514/84 ,  Y10S514/912 ,  A61K2300/00

Abstract: The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.

公开(公告)号：EP0948357A1

公开(公告)日：1999-10-13

申请号：EP97947519.0

申请日：1997-11-17

Applicant: ALCON LABORATORIES, INC.

Inventor： ASGHARIAN, Bahram

IPC: A61K9 ,  A61K31 ,  A61K33 ,  A61K47 ,  A61L2 ,  A61L12 ,  A61P27 ,  G02C13

CPC classification number: A61K33/22 ,  A61K9/0048 ,  A61K31/13 ,  A61K31/138 ,  A61K47/18 ,  A61L12/147 ,  Y10S514/839 ,  Y10S514/84 ,  Y10S514/912 ,  A61K2300/00

Abstract: The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.

公开(公告)号：EP0771347A1

公开(公告)日：1997-05-07

申请号：EP96921427.0

申请日：1996-06-07

Applicant: ALCON LABORATORIES, INC.

Inventor： CHOWHAN, Masood, A. ,  QUINTANA, Ronald, P. ,  ASGHARIAN, Bahram ,  HONG, Bor-Shyue ,  BILBAULT, Thierry ,  ROSENTHAL, Ruth, Ann

IPC: G02C13 ,  A61L2 ,  A61L12 ,  C11D3 ,  C11D7 ,  C11D17

CPC classification number: C11D3/046 ,  A61L12/082 ,  A61L12/145 ,  C11D3/0078 ,  C11D3/042 ,  C11D3/2044 ,  C11D3/2065 ,  C11D3/38618 ,  C11D3/38663 ,  C11D3/48

Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lenses. Methods for a daily use regimen are also disclosed.

公开(公告)号：EP0999854A1

公开(公告)日：2000-05-17

申请号：EP98936846.9

申请日：1998-07-17

Applicant: ALCON LABORATORIES, INC.

Inventor： ASGHARIAN, Bahram

IPC: A61K47/36 ,  A61K47/02 ,  A61K9/00

CPC classification number: A61L31/16 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/36 ,  A61L31/041 ,  A61L31/042 ,  A61L31/14 ,  A61L2300/00 ,  A61L2430/16 ,  Y10S514/944 ,  C08L5/00 ,  C08L71/00

Abstract: The present invention is directed to viscoelastic systems comprising a combination of a galactomannan polysaccharide containing composition and borate containing composition. The two compositions gel or partially gel upon combination. The present invention also discloses methods of using the systems during surgery and, in particular, eye surgery.

公开(公告)号：EP0970175A1

公开(公告)日：2000-01-12

申请号：EP98935663.9

申请日：1998-07-17

Applicant: ALCON LABORATORIES, INC.

Inventor： ASGHARIAN, Bahram

IPC: C11D3/22 ,  C11D3/02

CPC classification number: C11D3/046 ,  A61L2/0023 ,  A61L2/04 ,  A61L12/08 ,  C11D3/0078 ,  C11D3/042 ,  C11D3/222 ,  C11D3/225 ,  C11D17/003 ,  Y10S514/912 ,  Y10S514/944

Abstract: Contact lens care compositions for the treatment of hard contact lenses are disclosed. The compositions are useful for rinsing, cleaning, disinfecting and storing of hard contact lenses. The compositions contain a unique gelling system involving galactomannan polysaccharides and borates to allow for the conditioning of the lens when it is reinserted in the eye of the user. Methods of using these compositions are also disclosed.