公开(公告)号：UA84175C2

公开(公告)日：2008-09-25

申请号：UAA200606021

申请日：2004-11-18

Applicant: ARRAY BIOPHARMA INC

Inventor： MARLOW ALLISON L ,  WALLACE ELI ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  YANG HONG WOON ,  BLAKE JIM

IPC: A01N33/02 ,  A01N43/42 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/64 ,  A01N43/90 ,  A61K20060101 ,  A61K31/40 ,  A61K31/415 ,  A61K31/416 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/655 ,  C07D20060101 ,  C07D209/44 ,  C07D209/46 ,  C07D213/80 ,  C07D213/82 ,  C07D215/48 ,  C07D221/04 ,  C07D231/56 ,  C07D237/24 ,  C07D237/26 ,  C07D237/28 ,  C07D237/32 ,  C07D239/74 ,  C07D401/04 ,  C07D401/06 ,  C07D403/02 ,  C07D413/02 ,  C07D413/04 ,  C07D413/14 ,  C07D417/02 ,  C07D417/04 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

公开(公告)号：HK1106131A1

公开(公告)日：2008-03-07

申请号：HK07111370

申请日：2007-10-22

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  LYSSIKATOS JOSEPH P ,  AICHER TOM ,  LAIRD ELLEN ,  ROBINSON JOHN ,  ALLEN SHELLEY

IPC: A61K20060101 ,  C07D20060101

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：MX2007013539A

公开(公告)日：2008-01-24

申请号：MX2007013539

申请日：2006-05-01

Applicant: ARRAY BIOPHARMA INC

Inventor： ZHAO QIAN ,  WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  ROBINSON JOHN E ,  HANS JEREMY ,  LAIRD ELLEN ,  ALLEN SHELLEY ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  VOEGTLI WALTER CHARLES

IPC: C07D417/04

Abstract: Esta invencion se relaciona a inhibidores de cinesinas mitoticas, particularmente KSP, y metodos para producir estos inhibidores. La invencion tambien proporciona composiciones farmaceuticas las cuales comprenden los inhibidores de la invencion y metodos para utilizar los inhibidores y composiciones farmaceuticas en el tratamiento y prevencion de varios desordenes.

公开(公告)号：CA2608201A1

公开(公告)日：2007-04-19

申请号：CA2608201

申请日：2006-05-17

Applicant: ARRAY BIOPHARMA INC ,  ASTRAZENECA AB

Inventor： MARLOW ALLISON L ,  BOOTH REBECCA JANE ,  STOREY RICHARD ANTHONY ,  PITTAM JOHN DAVID ,  SEO JEONGBEOB ,  FIELDING MARK RICHARD ,  LEONARD JOHN ,  BLAKE JIM ,  YANG HONG WOON ,  LYSSIKATOS JOSEPH P ,  WALLACE ELI

IPC: C07D213/84 ,  A61K31/44 ,  C07D213/63

Abstract: This invention relates to a series of novel heterocyclic compounds that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：AU2006242380A1

公开(公告)日：2006-11-09

申请号：AU2006242380

申请日：2006-05-01

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  DELISLE ROBERT KIRK ,  VOEGTLI WALTER CHARLES ,  ROBINSON JOHN E ,  LYSSIKATOS JOSEPH P ,  LAIRD ELLEN ,  ALLEN SHELLEY ,  WALLACE ELI M ,  CORRETTE CHRISTOPHER P ,  ZHAO QIAN

IPC: C07D417/04

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：BRPI0413152A

公开(公告)日：2006-10-03

申请号：BRPI0413152

申请日：2004-08-20

Applicant: ARRAY BIOPHARMA INC

Inventor： WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  MARLOW ALLISON L ,  HURLEY T BRIAN ,  KOCH KEVIN

IPC: C07D235/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07F9/6506 ,  C07F9/6558 ,  A61K31/4184 ,  C07D235/08

Abstract: Disclosed are amino acid prodrugs of compounds of the formula I and pharmaceutically acceptable salts thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.

公开(公告)号：NO20061432A

公开(公告)日：2006-08-25

申请号：NO20061432

申请日：2006-03-29

Applicant: ARRAY BIOPHARMA INC

Inventor： WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  MARLOW ALLISON L ,  HURLEY BRIAN T ,  KOCH KEVIN

IPC: C07D235/08 ,  C07D235/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07F9/6506 ,  C07F9/6558

CPC classification number: C07D235/06 ,  C04B35/632 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07F9/65068 ,  C07F9/65586

公开(公告)号：NO20062692A

公开(公告)日：2006-08-14

申请号：NO20062692

申请日：2006-06-12

Applicant: ARRAY BIOPHARMA INC

Inventor： WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  MARLOW ALLISON L ,  BLAKE JIM ,  SEO JEONGBEOB ,  YANG HONG WOON

IPC: A01N33/02 ,  A01N43/42 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/64 ,  A01N43/90 ,  A61K20060101 ,  A61K31/40 ,  A61K31/415 ,  A61K31/416 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/655 ,  C07D20060101 ,  C07D209/44 ,  C07D209/46 ,  C07D213/80 ,  C07D213/82 ,  C07D215/48 ,  C07D221/04 ,  C07D231/56 ,  C07D237/24 ,  C07D237/26 ,  C07D237/28 ,  C07D237/32 ,  C07D239/74 ,  C07D401/04 ,  C07D401/06 ,  C07D403/02 ,  C07D413/02 ,  C07D413/04 ,  C07D413/14 ,  C07D417/02 ,  C07D417/04 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

CPC classification number: C07D209/46 ,  C07D213/80 ,  C07D213/82 ,  C07D215/48 ,  C07D231/56 ,  C07D237/24 ,  C07D237/28 ,  C07D237/32 ,  C07D239/74 ,  C07D401/04 ,  C07D401/06 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

公开(公告)号：CA2584866A1

公开(公告)日：2006-04-27

申请号：CA2584866

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  ZHAO QIAN ,  ROBINSON JOHN ,  ALLEN SHELLEY ,  LYSSIKATOS JOSEPH P ,  LAIRD ELLEN ,  AICHER TOM ,  WALLACE ELI M

IPC: A61K31/4245 ,  C07D413/00 ,  C07D417/00

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：IS8392A

公开(公告)日：2006-03-31

申请号：IS8392

申请日：2006-03-31

Applicant: ARRAY BIOPHARMA INC

Inventor： WALLACE ELI M ,  HURLEY BRIAN ,  YANG HOON WOON ,  LYSSIKATOS JOSEPH P ,  MARLOW ALLISON L ,  BLAKE JIM

IPC: A61K31/42 ,  C07D20060101 ,  C07D261/20 ,  C07D471/04