公开(公告)号：ES2080326T3

公开(公告)日：1996-02-01

申请号：ES91912909

申请日：1991-07-19

Applicant: BASF AG

Inventor： BACH ALFRED ,  HILLEN HEINZ ,  BIALOJAN SIEGFRIED

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57

公开(公告)号：CA2195242A1

公开(公告)日：1996-02-01

申请号：CA2195242

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: C07D233/84 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18 ,  A61K31/52 ,  A61K31/505 ,  A61K31/53

Abstract: The present invention relates to the use of heterocyclic compounds of formula (I) Het - A - B - Ar in which Het A, B and Ar have the meanings given in the description. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.

公开(公告)号：CA2195240A1

公开(公告)日：1996-02-01

申请号：CA2195240

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12

Abstract: The use is disclosed of thiazole and thiadiazole compounds having the formula (I), in which R1, A, B and Ar have the meanings given in the description. These compounds have a high affinity to the dopamine D3 receptor and are therefore useful for treating diseases of the central nervous system.

公开(公告)号：DK0540560T3

公开(公告)日：1995-12-27

申请号：DK91912909

申请日：1991-07-19

Applicant: BASF AG

Inventor： BIALOJAN SIEGFRIED ,  BACH ALFRED ,  HILLEN HEINZ

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57 ,  A61K37/54

公开(公告)号：DE58909261D1

公开(公告)日：1995-06-29

申请号：DE58909261

申请日：1989-11-25

Applicant: BASF AG

Inventor： BACH ALFRED ,  STRUBE KARL-HERMANN ,  KOERWER WOLFGANG

IPC: A61K38/36 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C07K14/46 ,  C07K14/75 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/22 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/57 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12R1/19 ,  C12R1/91

Abstract: PCT No. PCT/EP89/01427 Sec. 371 Date May 14, 1991 Sec. 102(e) Date May 14, 1991 PCT Filed Nov. 25, 1989 PCT Pub. No. WO90/06362 PCT Pub. Date Jun. 14, 1990Pure glycosylated, partially glycosylated or unglycosylated polypeptides have the amino-acid sequence of ancrod, in which up to 5 amino acid residues can be replaced by residues of other natural amino acids, and are suitable for controlling diseases.

公开(公告)号：AT123056T

公开(公告)日：1995-06-15

申请号：AT90900807

申请日：1989-11-25

Applicant: BASF AG

Inventor： BACH ALFRED ,  STRUBE KARL-HERMANN ,  KOERWER WOLFGANG

IPC: A61K38/36 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C07K14/46 ,  C07K14/75 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/22 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/57 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12R1/19 ,  C12R1/91

Abstract: PCT No. PCT/EP89/01427 Sec. 371 Date May 14, 1991 Sec. 102(e) Date May 14, 1991 PCT Filed Nov. 25, 1989 PCT Pub. No. WO90/06362 PCT Pub. Date Jun. 14, 1990Pure glycosylated, partially glycosylated or unglycosylated polypeptides have the amino-acid sequence of ancrod, in which up to 5 amino acid residues can be replaced by residues of other natural amino acids, and are suitable for controlling diseases.

公开(公告)号：ES2033212A6

公开(公告)日：1994-05-01

申请号：ES8904164

申请日：1989-12-07

Applicant: BASF AG

Inventor： BACH ALFRED ,  STRUBE KARL-HERMANN ,  KOERWER WOLFGANG

IPC: A61K38/36 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C07K14/46 ,  C07K14/75 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/22 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/57 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12R1/19 ,  C12R1/91 ,  C12N5/16 ,  C07K13/00

Abstract: Procedimiento para la obtención de péptidos puramente glicosilados, parcialmente glicosilados o no glicosilados con la secuencia de aminoácidos: 1 viggdecnin ehrflvavye gtx 1 wtficgg vlihpewvit aehcarrrmn 51 lvfgmhrkse kfddeqeryp kkryfircx 2k trtswdedim lirlnkpvx 3n 101 sehiaplslp snppivgsdc rvmgwgsinr rihvlsdepr caninlhx 4ft 151 mchglfrkmp kkgrvlcagd lrgrrdscns dsggplicne elhgivargp 201 npcaqpnkpa lytsvydyrd wvnnviagx 5a tcsp Comprende aislar el mRNA de un organismo adecuado; traducirlo en cDNA de doble hebras; aplicar este cDNA en un vector de clonación; y aplicar posteriormente una biblioteca cDNA, para expresar así secuencias de DNA en dicho organismo huesped que codifiquen las secuencias de péptido anteriormente indicados. Los péptidos son adecuados para la lucha contra enfermedades.

公开(公告)号：CA2098706A1

公开(公告)日：1992-06-23

申请号：CA2098706

申请日：1991-12-12

Applicant: BASF AG

Inventor： BACH ALFRED ,  UNGER LILIANE ,  BIALOJAN SIEGFRIED ,  SEEBURG PETER

IPC: A61K38/00 ,  C07K14/00 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12P21/02 ,  C12Q1/02 ,  C12R1/91 ,  G01N33/554 ,  G01N33/566

Abstract: 2098706 9211362 PCTABS00014 The description relates to novel polypeptides which are 5HT1X receptors. The polypeptides are produced by genetic engineering.

公开(公告)号：CA2083286A1

公开(公告)日：1992-01-27

申请号：CA2083286

申请日：1991-07-19

Applicant: BASF AG

Inventor： BIALOJAN SIEGFRIED ,  HILLEN HEINZ ,  BACH ALFRED

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57 ,  A61K38/48

Abstract: Glycosylated, partially glycosylated and non-glycosylated polypeptides which have the amino-acid sequences indicated in the sequence listing and in which up to 10 amino-acid residues can be replaced by residues of other natural amino acids are described. The peptides are suitable for controlling diseases.

公开(公告)号：AU4664489A

公开(公告)日：1990-06-26

申请号：AU4664489

申请日：1989-11-25

Applicant: BASF AG

Inventor： BACH ALFRED ,  STRUBE KARL-HERMANN ,  KOERWER WOLFGANG

IPC: A61K38/36 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C07K14/46 ,  C07K14/75 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/22 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/57 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12R1/19 ,  C12R1/91 ,  A61K37/547

Abstract: PCT No. PCT/EP89/01427 Sec. 371 Date May 14, 1991 Sec. 102(e) Date May 14, 1991 PCT Filed Nov. 25, 1989 PCT Pub. No. WO90/06362 PCT Pub. Date Jun. 14, 1990Pure glycosylated, partially glycosylated or unglycosylated polypeptides have the amino-acid sequence of ancrod, in which up to 5 amino acid residues can be replaced by residues of other natural amino acids, and are suitable for controlling diseases.