公开(公告)号：CA2067224C

公开(公告)日：2001-02-13

申请号：CA2067224

申请日：1990-11-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS W

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/58 ,  A61K47/48 ,  A61P7/02 ,  C07K14/815 ,  C07K17/08 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K17/06

Abstract: Hirudin/polyalkylene glycol derivatives of the formula (A-(CH2)n-¢O-(CH2)n!m-B-!p Hir ¢sic! I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：LV5809B4

公开(公告)日：1997-04-20

申请号：LV960306

申请日：1996-07-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS W

IPC: A61K38/58 ,  A61K47/48 ,  C07K14/815 ,  C07K17/08

公开(公告)号：AT135374T

公开(公告)日：1996-03-15

申请号：AT91900751

申请日：1990-11-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS WOLFGANG

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/58 ,  A61K47/48 ,  A61P7/02 ,  C07K14/815 ,  C07K17/08 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

Abstract: PCT No. PCT/EP90/01998 Sec. 371 Date May 29, 1992 Sec. 102(e) Date May 29, 1992 PCT Filed Nov. 22, 1990 PCT Pub. No. WO91/08229 PCT Pub. Date Jun. 13, 1991Hirudin/polyalkylene glycol derivatives of the formula[A-(CH2)n-[O-(CH2)nlm-B-]p Hir [sic]I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：DK587688A

公开(公告)日：1989-06-14

申请号：DK587688

申请日：1988-10-21

Applicant: BASF AG

Inventor： KOERWER WOLFGANG ,  KURFUERST MANFRED ,  BALDINGER VERENA ,  DOERPER THOMAS ,  SCHWARZ MARGARETE

IPC: A61K38/46 ,  A61P7/02 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91 ,  C07K13/00 ,  C07H21/04

公开(公告)号：DK587588A

公开(公告)日：1989-06-14

申请号：DK587588

申请日：1988-10-21

Applicant: BASF AG

Inventor： KOERWER WOLFGANG ,  KURFUERST MANFRED ,  BALDINGER VERENA ,  DOERPER THOMAS

IPC: A61K38/46 ,  A61P7/02 ,  C07K1/22 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91 ,  C07K13/00 ,  C07H21/04

公开(公告)号：DK587688D0

公开(公告)日：1988-10-21

申请号：DK587688

申请日：1988-10-21

Applicant: BASF AG

Inventor： KOERWER WOLFGANG ,  KURFUERST MANFRED ,  BALDINGER VERENA ,  DOERPER THOMAS ,  SCHWARZ MARGARETE

IPC: A61K38/46 ,  A61P7/02 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91 ,  C07K13/00 ,  C07H21/04

公开(公告)号：HU211658A9

公开(公告)日：1995-12-28

申请号：HU9500710

申请日：1995-06-30

Applicant: BASF AG

Inventor： BACH ALFRED ,  STRUBE KARL-HERMANN ,  KOERWER WOLFGANG

IPC: A61K38/36 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C07K14/46 ,  C07K14/75 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/22 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/57 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12R1/19 ,  C12R1/91

Abstract: PCT No. PCT/EP89/01427 Sec. 371 Date May 14, 1991 Sec. 102(e) Date May 14, 1991 PCT Filed Nov. 25, 1989 PCT Pub. No. WO90/06362 PCT Pub. Date Jun. 14, 1990Pure glycosylated, partially glycosylated or unglycosylated polypeptides have the amino-acid sequence of ancrod, in which up to 5 amino acid residues can be replaced by residues of other natural amino acids, and are suitable for controlling diseases.

公开(公告)号：AT119571T

公开(公告)日：1995-03-15

申请号：AT90917037

申请日：1990-11-22

Applicant: BASF AG

Inventor： MEYER THOMAS ,  FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  STRUBE KARL-HERMANN ,  BIALOJAN SIEGFRIED

IPC: A61K35/62 ,  A61K38/00 ,  C12N9/48

公开(公告)号：DE59006998D1

公开(公告)日：1994-10-06

申请号：DE59006998

申请日：1990-12-04

Applicant: BASF AG

Inventor： KOERWER WOLFGANG

IPC: C07K1/02 ,  C07K14/00 ,  C07K14/31 ,  C07K14/815 ,  C07K19/00 ,  C12N15/09 ,  C12N15/15 ,  C12N15/31 ,  C12N15/62 ,  C12P21/02 ,  C12P21/06 ,  C12R1/19 ,  C07K7/10

公开(公告)号：MX9206055A

公开(公告)日：1993-04-01

申请号：MX9206055

申请日：1992-10-21

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  KROEGER BRUKHARD ,  BIALOJAN SIEGFRIED

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/14 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C07K15/00

Abstract: PCT No. PCT/EP92/02198 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Sep. 23, 1992 PCT Pub. No. WO93/09231 PCT Pub. Date May 13, 1993A novel thrombin inhibitory protein from ticks with a molecular weight of about 26000 dalton and the partial amino acid sequences Val-Ala-Lys-Phe-Ala-X-Asn-Ser-Gly-Ser-Glu-Thr-Gly (SEQ ID NO: 8), His-Ala-Y-Phe-Glu (SEQ ID NO: 3), Arg-Val-Ser-Asp-Phe-Glu (SEQ ID NO: 4), Phe-Val-Tyr-Thr-Ile-Glu (SEQ ID NO: 6), where X and Y can be identical or different and each is a naturally occurring amino acid, is suitable for controlling diseases.