公开(公告)号：JP2004043502A

公开(公告)日：2004-02-12

申请号：JP2003358317

申请日：2003-10-17

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/715 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K14/7151

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα (tumor necrusis factor α).
SOLUTION: This protein has molecular weight of about 42,000 daltons measured by SDS gel electrophoresis and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and a mutein is obtained by subjecting the protein having the TNFα suppressing action to a proper substitution, deletion or addition of an amino acid or peptide or the change of a glycoside group without strongly lowering the TNFα suppressing action.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2002302500A

公开(公告)日：2002-10-18

申请号：JP2002013319

申请日：2002-01-22

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα. SOLUTION: The protein has a molecular weight of about 42,000 daltons in the first glycosylated form and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and the protein and a mutein obtained by the proper substitution, deletion or addition of an amino acid or peptide for/ from/or to/the protein or the change of a glycoside group without strongly lowering the action of the protein are used for suppressing the abnormal increase in the TNF-α.

公开(公告)号：WO0061608A3

公开(公告)日：2001-01-11

申请号：PCT/EP0002710

申请日：2000-03-28

Applicant: BASF AG

Inventor： HILLEN HEINZ ,  SCHMIDT MARTIN ,  MACK HELMUT ,  SEITZ WERNER ,  HAUPT ANDREAS ,  ZECHEL JOHANN-CHRISTIAN ,  KLING ANDREAS

IPC: C12N9/99 ,  A61K38/00 ,  A61P1/04 ,  A61P1/18 ,  A61P5/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/02 ,  C07B43/00 ,  C07D401/12 ,  C07K5/06 ,  C07K5/065 ,  C07K5/062 ,  A61K38/05 ,  C07D409/12 ,  C07K5/068 ,  C07K5/072 ,  C07K5/078

CPC classification number: C07D401/12 ,  A61K38/00 ,  C07B43/00 ,  C07K5/06078

Abstract: The invention relates to peptidic substances, to the production of said substances and to their use as complement inhibitors. In particular, the invention relates to substances with a guanidine or amidine radical as the terminal group, especially inhibitors of the complement proteases C1s and C1r.

Abstract translation: 本发明涉及肽的物质，它们的制备和它们作为补体抑制剂的用途。 具体而言，存在与一个胍或脒基作为末端基团的物质。 特别地，本发明涉及的C1s和C1R Komplementproteasen的抑制剂。

公开(公告)号：WO9201794A3

公开(公告)日：1992-03-05

申请号：PCT/EP9101361

申请日：1991-07-19

Applicant: BASF AG

Inventor： BACH ALFRED ,  HILLEN HEINZ ,  BIALOJAN SIEGFRIED

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57 ,  A61K37/54

CPC classification number: C12N9/6418 ,  A61K38/00

Abstract: Described are glycosylated, partially glycosylated or unglycosylated polypeptides with the amino-acid sequence given in the sequence protocol and in which up to 10 amino acid groups can be replaced by other, naturally occurring, amino acids. The peptides are suitable for use in treating illnesses.

公开(公告)号：TR200102913T2

公开(公告)日：2002-01-21

申请号：TR200102913

申请日：2000-03-28

Applicant: BASF AG

Inventor： HILLEN HEINZ ,  SCHMIDT MARTIN ,  MACK HELMUT ,  SEITZ WERNER ,  HAUPT ANDREAS ,  ZECHEL JOHANN-CHRISTIAN ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/55 ,  A61P1/04 ,  A61P1/18 ,  A61P5/14 ,  A61P7/02 ,  C12N9/99 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/02 ,  C07B43/00 ,  C07D401/12 ,  C07D409/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/068 ,  C07K5/072 ,  C07K5/078 ,  A61K38/05

Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.

公开(公告)号：CA2369378A1

公开(公告)日：2000-10-19

申请号：CA2369378

申请日：2000-03-28

Applicant: BASF AG

Inventor： HILLEN HEINZ ,  SCHMIDT MARTIN ,  SEITZ WERNER ,  MACK HELMUT ,  ZECHEL JOHANN-CHRISTIAN ,  KLING ANDREAS ,  HAUPT ANDREAS

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61P1/04 ,  A61P1/18 ,  A61P5/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/02 ,  C07B43/00 ,  C07D401/12 ,  C07D409/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/068 ,  C07K5/072 ,  C07K5/078 ,  A61K38/05

Abstract: The invention relates to peptidic substances, to the production of said substances and to their use as complement inhibitors. In particular, the invention relates to substances with a guanidine or amidine radical as the terminal group, especially inhibitors of the complement proteases C1s and C1 r.

公开(公告)号：ZA9809312B

公开(公告)日：2000-04-13

申请号：ZA9809312

申请日：1998-10-13

Applicant: BASF AG

Inventor： PUHL MICHAEL ,  ZECHEL JOHANN-CHRISTIAN ,  DITRICH KLAUS ,  HILLEN HEINZ ,  KOHL TANJA ,  ERHARDT MELANIE ,  HERGENROEDER STEFAN ,  MARKERT CLAUS OTTO

IPC: C07D333/40 ,  A61K31/198 ,  A61K31/27 ,  A61K31/381 ,  A61K31/4704 ,  A61K31/498 ,  A61P1/04 ,  A61P1/18 ,  A61P7/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  C07C271/12 ,  C07C271/20 ,  C07C323/56 ,  C07D215/48 ,  C07D241/44 ,  C07D333/38 ,  C07D ,  A61K ,  C07C

CPC classification number: C07C271/20 ,  C07C323/56 ,  C07C2603/18 ,  C07D241/44 ,  C07D333/38

公开(公告)号：NO20001846L

公开(公告)日：2000-04-10

申请号：NO20001846

申请日：2000-04-10

Applicant: BASF AG

Inventor： PUHL MICHAEL ,  ZECHEL JOHANN-CHRISTIAN ,  DITRICH KLAUS ,  HILLEN HEINZ ,  KOHL TANJA ,  ERHARDT MELANIE ,  HERGENROEDER STEFAN ,  MARKERT CLAUS OTTO

IPC: C07D333/40 ,  A61K31/198 ,  A61K31/27 ,  A61K31/381 ,  A61K31/4704 ,  A61K31/498 ,  A61P1/04 ,  A61P1/18 ,  A61P7/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  C07C271/12 ,  C07C271/20 ,  C07C323/56 ,  C07D215/48 ,  C07D241/44 ,  C07D333/38 ,  C07D333/16 ,  C07D241/42 ,  C07D215/14 ,  C07C271/22 ,  A61K31/38 ,  A61K31/47 ,  A61K31/495

Abstract: Pharmaceutically active compounds are prepared as described and used to produce pharmaceutical preparations for treating diseases.

公开(公告)号：BR9708609A

公开(公告)日：1999-08-03

申请号：BR9708609

申请日：1997-04-04

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  KLINGE DAGMAR ,  AMBERG WILHELM ,  KLING ANDREAS ,  HILLEN HEINZ ,  UNGER LILIANE ,  ELGER BERND

IPC: C07D251/30 ,  A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  A61K31/529 ,  A61K31/53 ,  A61P7/00 ,  A61P9/00 ,  A61P9/02 ,  A61P9/12 ,  A61P13/00 ,  A61P13/08 ,  A61P13/12 ,  C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/48 ,  C07D403/12 ,  C07D491/044

Abstract: The invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings defined in the description, to the preparation of these compounds and to their use as drugs.

公开(公告)号：CZ9803247A3

公开(公告)日：1999-04-14

申请号：CZ324798

申请日：1997-04-04

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  KLINGE DAGMAR ,  AMBERG WILHELM ,  KLING ANDREAS ,  HILLEN HEINZ ,  UNGER LILIANE ,  ELGER BERND

IPC: C07D251/30 ,  A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  A61K31/529 ,  A61K31/53 ,  A61P7/00 ,  A61P9/00 ,  A61P9/02 ,  A61P9/12 ,  A61P13/00 ,  A61P13/08 ,  A61P13/12 ,  C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/48 ,  C07D403/12 ,  C07D491/044

CPC classification number: C07D239/46