公开(公告)号：AU783697B2

公开(公告)日：2005-11-24

申请号：AU5701400

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569 ,  C12N15/77

Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. Glutamicum based on genetic engineering of PTS genes in this organism.

公开(公告)号：DE10359661A1

公开(公告)日：2005-07-28

申请号：DE10359661

申请日：2003-12-18

Applicant: BASF AG

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  RUFFER UWE ,  GRAEF CLAUDIA ISABELLA ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C07K14/195 ,  C12N15/31

Abstract: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.

公开(公告)号：ZA200404424B

公开(公告)日：2005-06-06

申请号：ZA200404424

申请日：2004-06-04

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C07K ,  C12P ,  C12Q ,  C12N

Abstract: Isolated nucleic acid (I) that encodes any of 50 amino acid sequences (II) that have, at specific positions, an amino acid (aa) alteration. The specification includes (i) a table identifying the function of (II) and the nature/position of the amino acid exchange and (ii) sequences for (I) and (II). Independent claims are also included for the following: (1) vector that contains at least one (I); (2) host cell transfected with at least one vector of component (1); and (3) preparing fine chemicals by culturing cells of component (2).

公开(公告)号：ZA200200585B

公开(公告)日：2004-10-27

申请号：ZA200200585

申请日：2002-01-23

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  KROEGER BURKHARD ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  ZELDER OSKAR

IPC: C07K20060101 ,  C12N20060101 ,  C12P20060101 ,  C12Q20060101 ,  C12N ,  C07K

公开(公告)号：AU2002365499A8

公开(公告)日：2003-06-10

申请号：AU2002365499

申请日：2002-10-31

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR ,  SCHRODER HARTWIG

IPC: C12N15/11 ,  C07K14/34 ,  C12N1/21 ,  C12N15/63 ,  C12P13/08 ,  C12N15/10 ,  C12R1/15 ,  C12R1/13

Abstract: Isolated nucleic acid (I) that encodes particular protein sequences (II) that have, at specific positions, an amino acid alteration. Independent claims are also included for: (1) Vector that contains at least one (I); (2) Host cell transfected with at least one vector of (1); and (3) Method for preparing fine chemicals by culturing cells of (2).

公开(公告)号：AU2002346804A1

公开(公告)日：2003-05-19

申请号：AU2002346804

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  KROGER BURKHARD ,  HABERHAUER GREGOR ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  POMPEJUS MARKUS

IPC: C07K14/34 ,  C12N1/21 ,  C12N15/31 ,  C12P13/08 ,  C12N15/63

Abstract: The invention relates to nucleic acid molecules, the use thereof in the construction of bio-engineered improved microorganisms and to methods for the production of fine chemicals, especially amino acids, with the aid of said bio-engineered improved microorganisms.

公开(公告)号：AU2002346803A1

公开(公告)日：2003-05-19

申请号：AU2002346803

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  POMPEJUS MARKUS ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR ,  KROGER BURKHARD ,  ZELDER OSKAR

IPC: C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C12N15/52 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：DE10154177A1

公开(公告)日：2003-05-08

申请号：DE10154177

申请日：2001-11-05

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N15/11 ,  C07K14/34 ,  C12N1/21 ,  C12N15/63 ,  C12P13/08 ,  C12N15/77 ,  C12P13/04

Abstract: Isolated nucleic acid (I) that encodes particular protein sequences (II) that have, at specific positions, an amino acid alteration. Independent claims are also included for: (1) Vector that contains at least one (I); (2) Host cell transfected with at least one vector of (1); and (3) Method for preparing fine chemicals by culturing cells of (2).

公开(公告)号：HU0203647A2

公开(公告)日：2003-01-28

申请号：HU0203647

申请日：2000-06-23

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  KROEGER BURKHARD ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  ZELDER OSKAR

IPC: C12N15/09 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/21 ,  C12N9/00 ,  C12N9/02 ,  C12N9/18 ,  C12N15/31 ,  C12N15/52 ,  C12P20060101 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12R1/15

Abstract: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.

公开(公告)号：ES2174768T1

公开(公告)日：2002-11-16

申请号：ES00942322

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569 ,  C12N15/77

Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. Glutamicum based on genetic engineering of PTS genes in this organism.