公开(公告)号：ZA9901214B

公开(公告)日：2000-08-16

申请号：ZA9901214

申请日：1999-02-16

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASHACK MANFRED ,  UNGER LILIAN

IPC: A61K31/505 ,  A61K31/506 ,  A61P5/14 ,  A61P9/02 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D ,  A62K

CPC classification number: C07D239/47 ,  C07D239/60 ,  C07D403/12

公开(公告)号：CZ20001788A3

公开(公告)日：2000-08-16

申请号：CZ20001788

申请日：1998-11-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  HILLEN HEINZ ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/42 ,  A61K31/425 ,  A61P9/00 ,  A61P11/06 ,  A61P13/00 ,  C07D261/12 ,  C07D263/38 ,  C07D275/03 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12

公开(公告)号：NO20004075A

公开(公告)日：2000-08-15

申请号：NO20004075

申请日：2000-08-15

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/505 ,  A61K31/506 ,  A61P5/14 ,  A61P9/02 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

CPC classification number: C07D239/47 ,  C07D239/60 ,  C07D403/12

公开(公告)号：BG103502A

公开(公告)日：2000-07-31

申请号：BG10350299

申请日：1999-06-18

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENR OEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D253/06 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D403/12 ,  C07D491/04 ,  C07D253/08 ,  C07D241/20 ,  C07D237/18 ,  C07D237/20 ,  C07D237/22

Abstract: The invention relates to derivatives of carboxylic acids with the formula where the substituents have the meanings listed in the description, as well as to their preparation and application as endothelial receptors. 9 claims

公开(公告)号：CA2355251A1

公开(公告)日：2000-06-29

申请号：CA2355251

申请日：1999-12-09

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  UNGER LILIANE ,  HERGENRODER STEFAN ,  BAUMANN ERNST ,  JANSEN ROLF ,  RIECHERS HARTMUT ,  KETTSCHAU GEORG ,  AMBERG WILHELM

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048 ,  C07D239/60

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in whic h the substituents have the following meanings: R1 is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR9; Y is nitrogen or CR10; Q is nitrogen or CR11, provided that if Q is nitrogen then X is CR5 and Y is CR10; R2 and R3 are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R4 is a rest (b) or (c); and R5 is hydrogen, C 1- C4-alkyl. The invention further relates to their preparation and their use a s endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R1, R2, R3, R4 and R5 have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：CZ2000743A3

公开(公告)日：2000-06-14

申请号：CZ2000743

申请日：1998-08-24

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/505 ,  A61P9/10 ,  A61P9/12 ,  C07D239/04 ,  C07D263/38 ,  C07D277/34

公开(公告)号：NO20002154L

公开(公告)日：2000-05-12

申请号：NO20002154

申请日：2000-04-27

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  HILLEN HEINZ ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILLIANE

IPC: C07D249/12 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/433 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D231/20 ,  C07D233/70 ,  C07D261/12 ,  C07D263/38 ,  C07D271/06 ,  C07D271/10 ,  C07D273/01 ,  C07D275/02 ,  C07D275/03 ,  C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/60 ,  C07D277/68 ,  C07D285/00 ,  C07D285/08 ,  C07D285/12 ,  C07D291/04 ,  C07D413/12 ,  C07D417/12 ,  C07D

Abstract: The present invention relates to carboxylic acid derivatives of the formula Ithe substituents having the meanings explained in the description, preparation and use as endothelin receptor antagonists.

公开(公告)号：ZA988053B

公开(公告)日：2000-03-22

申请号：ZA988053

申请日：1998-09-03

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D239/34 ,  C07D239/52 ,  C07D277/34 ,  C07D409/12 ,  C07D491/052 ,  C07D ,  A61K

公开(公告)号：CA2340167A1

公开(公告)日：2000-02-24

申请号：CA2340167

申请日：1999-08-07

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  UNGER LILIANE ,  AMBERG WILHELM ,  JANSEN ROLF ,  HERGENRODER STEFAN ,  KETTSCHAU GEORG

IPC: C07D251/22 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K45/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/52 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04

Abstract: The invention relates to new carboxylic acid derivatives of the formula (I), where the substituents have the meaning given in the description, their production and their use as endothelin-receptor antagonists.

公开(公告)号：DE19811915A1

公开(公告)日：1999-09-23

申请号：DE19811915

申请日：1998-03-18

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D239/34 ,  A61K31/41 ,  A61K31/495 ,  C07D239/70 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Carboxylic acid derivatives (I) and their salts and enantiomers are new. Carboxylic acid derivatives of formula R ZC(R )(BR )CH(R)OHet (I) and their salts and enantiomers are new. R = tetrazole or COR ; R = OR , 3-8C cycloalkyl, 1-8C alkyl, optionally substituted phenyl or benzyl, 3-6C alkenyl or optionally substituted 3-6C alkynyl; R = H, an alkali or alkaline earth metal cation or an organic ammonium ion; R = H, OH, NH2, NH-(1-4C alkyl), N-(1-4C alkyl)2, halo, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy or 1-4C alkylthio, or CR and CR together form a 5- or 6-membered ring; X, Y = N or CH; W = N or CR ; R = H, halo or 1-4C alkyl, or CR and CR or CR together form a 5- or 6-membered alkylene or alkenylene ring which is optionally substituted and in which one or more of the methylene groups may be replaced by O, S, NH or N-(1-4C alkyl); R = as R ; R , R = optionally substituted phenyl or naphthyl (which may be bound via a direct bond, or via methylene, ethylene, ethenylene, O, S, SO2, NH or N-alkyl), or optionally substituted 3-8C cycloalkyl; R = H, 1-8C alkyl, 3-8C alkenyl or 3-8C alkynyl (optionally substituted by halo, OH, SH, COOH, NO2, NH2, CN, 1-4C alkoxy, 3-6C alkenyloxy, 3-6C alkynyloxy, 1-4C alkylthio, 1-4C haloalkoxy, (1-4C alkyl)carbonyl, (1-4C alkoxy)carbonyl, 3-8C alkylcarbonylalkyl, NH(1-4C alkyl), N(1-4C alkyl)2, 3-8C cycloalkyl, heteroaryloxy or heteroaryl ,where the aryl groups may themselves be substituted), 3-8C cycloalkyl (optionally substituted by halo, OH, SH, COOH, NO2, CN, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 1-4C alkoxy, 1-4C alkylthio or 1-4C haloalkoxy), phenyl or naphthyl (both optionally substituted by halo, OH, NO2, NH2, CN, 1-4C alkyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy, phenoxy, 1-4C alkylthio, NH(1-4C alkyl), N(1-4C alkyl)2, dioxymethylene or dioxoethylene), or a 5- or 6-membered heteroaromatic group containing 1-3 N atoms and/or a S or O atom (which is optionally substituted by 1-4 halo atoms and/or one or two 1-4C alkyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy, 1-4C alkylthio, phenyl, phenoxy or benzoyl groups, where the phenyl rings may themselves be substituted); Z = O or S; B = 2-4C alkylene; Het = a heterocyclic group of formula (i) or (ii); T = O, S or NR ; R = 1-6C alkyl.