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    92.
    发明专利
    未知

    公开(公告)号：FI72733B

    公开(公告)日：1987-03-31

    申请号：FI810461

    申请日：1981-02-13

    Applicant: CIBA GEIGY AG

    Inventor： HARTMANN ALBERT ,  BASCHANG GERHARD ,  WACKER OSKAR ,  STANEK JAROSLAV

    IPC: C07H1/00 ,  A23K1/16 ,  A61K31/70 ,  A61P37/04 ,  C07H15/00 ,  C07K1/113 ,  C07K5/00 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07K5/06

    Abstract: Described are derivatives of pyranoses of the formula I, manufacturing processes and intermediates, and their use as medicaments. (I) The pyranose moiety in the compounds of the formula I is derived especially from D-glucose, but alternatively from D-galactose or D-mannose. Characteristic of the compounds of the formula I is the lower alkyl or phenyl-lower alkyl radical R8, which carries an oxycarbonyl, mercaptocarbonyl or aminocarbonyl group, which is bonded to an aliphatic, cycloaliphaticaliphatic, cycloaliphatic or aromatic hydrocarbon radical R0, each of which is optionally substituted and which may be interrupted by oxycarbonyl, mercaptocarbonyl and/or iminocarbonyl and which, like the remaining radicals of the formula I, is defined in patent claim 1.

    94.
    发明专利
    未知

    公开(公告)号：FI860707A

    公开(公告)日：1986-08-21

    申请号：FI860707

    申请日：1986-02-17

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  WACKER OSKAR

    IPC: C07K9/00 ,  C07K

    Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R is lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R and R are, independently of one another, hydrogen, lower alkanoyl or benzoyl, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino or lower alkoxy, R is hydrogen, carboxyl or lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, lower alkanoylamino-, hydroxyl-, guanidino-, lower alkanoyloxy-, 2-benzyloxycarbonylamino- ethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower- alkoxycarbonylaminoethylsulphinyl- or 2-lower-alkoxycarbonylamino- ethylsulphonyl-substituted lower alkyl, with the proviso that in the compounds in which the pyranose moiety is derived from D-glucose and, at the same time, n is 0, R , R and R are hydrogen, R is methyl, R is amino and R is hydroxyl, and in which the radicals R , R and R all have the same meaning, R , R and R are different from acetyl and butyryl when R is phenyl and, at the same time, R is hydrogen, and that R , R and R are different from acetyl when R and R are both methyl, and these compounds and salts thereof where appropriate have an antiviral action in vivo.

    96.
    发明专利
    未知

    公开(公告)号：DK77186D0

    公开(公告)日：1986-02-19

    申请号：DK77186

    申请日：1986-02-19

    Applicant: CIBA GEIGY AG

    Inventor： WACKER OSKAR ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  FECHTIG BRUNO ,  BASCHANG GERHARD

    IPC: C07K9/00 ,  C07H

    Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R , R and R are, independently of one another, lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino, C1-10-alkoxy, aryl-lower alkoxy, alkanoyloxy-lower alkoxy with up to 16 C atoms, aroyloxy-lower alkoxy, 3-cholesteryloxy or 2-trimethylammonioethyloxy, R is hydrogen, carboxyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, hydroxyl-, lower alkanoylamino-, lower alkanoyloxy-, 2-benzyloxycarbonylaminoethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower-alkoxycarbonyl- aminoethylsulphinyl-, 2-lower-alkoxycarbonylaminoethylsulphonyl- or guanidino-substituted lower alkyl, with the proviso that at least one of the radicals R and R is different from hydroxyl, amino and C1-7-alkoxy or R is different from hydrogen, carboxyl and alkoxycarbonyl with up to 7 C atoms in the alkoxy moiety, and these compounds and salts thereof where appropriate can be used for the prophylaxis and therapy of viral infections.

    98.
    发明专利
    未知

    公开(公告)号：FI852841L

    公开(公告)日：1986-01-26

    申请号：FI852841

    申请日：1985-07-22

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  FECHTIG BRUNO ,  HARTMANN ALBERT ,  LUKAS BOHUMIR ,  WACKER OSKAR

    IPC: A61K31/66 ,  A61P31/12 ,  C07F9/09 ,  C07F9/10 ,  C07F

    Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.

    99.
    发明专利
    未知

    公开(公告)号：FI852841A0

    公开(公告)日：1985-07-22

    申请号：FI852841

    申请日：1985-07-22

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  FECHTIG BRUNO ,  HARTMANN ALBERT ,  LUKAS BOHUMIR ,  WACKER OSKAR

    IPC: A61K31/66 ,  A61P31/12 ,  C07F9/09 ,  C07F9/10 ,  C07F

    Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.

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