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公开(公告)号：EP0205481A1
公开(公告)日：1986-12-30
申请号：EP85906029
申请日：1985-12-13
Applicant: CIBA GEIGY AG
Inventor： FECHTIG BRUNO , PETER HEINRICH
IPC: C07C239/00 , A61K31/16 , C07C67/00 , C07C239/22 , C07C259/06 , C07C271/64 , C07C103/30
CPC classification number: A61K31/16
Abstract: Des desferrioxamines B de O,O',O''-triacyle ayant la formule (I), dans laquelle Ac1, Ac2 et Ac3 représentent indépendamment les uns des autres un acyle résiduel d'un acide carboxylique ayant entre 1 et 24 atomes de C, et leurs sels, peuvent être utilisés dans la thérapie de maladies liées à un excès de fer (III) ou d'aluminium dans le corps, par exemple l'hémochromatose et l'hémosidérose, voire la maladie d'Alzheimer. Ces composés peuvent être obtenus par des procédés analogiques courants, en clivant le groupe protecteur dans une composition correspondante avec un groupe amine protecteur en fin de chaîne.
Abstract translation: 的乙O，O“ O”“Desferrioxamines - 具有下式的三酰基（I），其特征在于，AC1，AC2和AC3的彼此独立地具有1至24个碳原子的羧酸的酰基的残余 和它们的盐可以用于治疗与体内过量的铁（III）或铝有关的疾病，例如血色病和含铁血黄素病，或者甚至阿尔茨海默氏病。 这些化合物可以通过普通的类似方法，通过在链末端用保护胺基裂解相应组合物中的保护基而获得。
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公开(公告)号：ZA855580B
公开(公告)日：1986-03-26
申请号：ZA855580
申请日：1985-07-24
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , LUKAS BOHUMIR , FECHTIG BRUNO , WACKER OSKAR , HARTMANN ALBERT
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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公开(公告)号：DK337485A
公开(公告)日：1986-01-26
申请号：DK337485
申请日：1985-07-24
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , FECHTIG BRUNO , HARTMANN ALBERT , LUKAS BOHUMIR , WACKER OSKAR
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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公开(公告)号：ZA8407438B
公开(公告)日：1985-05-29
申请号：ZA8407438
申请日：1984-09-21
Applicant: CIBA GEIGY AG
Inventor： FECHTIG BRUNO
IPC: C07D501/22 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/20 , C07D501/59 , C07D , A61K
CPC classification number: C07D501/20
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公开(公告)号：NO843802L
公开(公告)日：1985-03-25
申请号：NO843802
申请日：1984-09-21
Applicant: CIBA GEIGY AG
Inventor： FECHTIG BRUNO
IPC: C07D501/22 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/20 , C07D501/59 , C07D
Abstract: 7 beta -Acylamido-3-cephem-4-carboxylic acid esters of the formula in which X denotes nitrogen or the group >/=-C-H, Y denotes oxygen, sulphur or the groups N-H or N-lower alkyl, A denotes methylene or methylene substituted by amino, substituted amino, hydroxyl, carboxyl, hydroxyimino or etherified or esterified hydroxyimino, R1 denotes hydrogen, halogen, lower alkyl or lower alkoxy, R2 denotes hydrogen, lower alkyl, phenyl or substituted phenyl and R3 denotes unsubstituted or substituted, aromatic, five- or six-membered heterocyclyl, phenyl or substituted phenyl, stereoisomers, mixtures of these stereoisomers and their salts have antibiotic properties and are active against gram-positive and gram-negative pathogens. The novel compounds are suitable for oral administration and can be used, for example, in the form of antibiotically active preparations for the treatment of infections. The novel compounds are prepared in a manner known per se from intermediates, some of which are novel.
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Patent Agency Ranking
公开(公告)号：DK452084D0
公开(公告)日：1984-09-21
申请号：DK452084
申请日：1984-09-21
Applicant: CIBA GEIGY AG
Inventor： FECHTIG BRUNO
IPC: C07D501/22 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/20 , C07D501/59 , C07D
Abstract: 7 beta -Acylamido-3-cephem-4-carboxylic acid esters of the formula in which X denotes nitrogen or the group >/=-C-H, Y denotes oxygen, sulphur or the groups N-H or N-lower alkyl, A denotes methylene or methylene substituted by amino, substituted amino, hydroxyl, carboxyl, hydroxyimino or etherified or esterified hydroxyimino, R1 denotes hydrogen, halogen, lower alkyl or lower alkoxy, R2 denotes hydrogen, lower alkyl, phenyl or substituted phenyl and R3 denotes unsubstituted or substituted, aromatic, five- or six-membered heterocyclyl, phenyl or substituted phenyl, stereoisomers, mixtures of these stereoisomers and their salts have antibiotic properties and are active against gram-positive and gram-negative pathogens. The novel compounds are suitable for oral administration and can be used, for example, in the form of antibiotically active preparations for the treatment of infections. The novel compounds are prepared in a manner known per se from intermediates, some of which are novel.
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公开(公告)号：AU3493571A
公开(公告)日：1973-05-03
申请号：AU3493571
申请日：1971-10-25
Applicant: CIBA GEIGY AG
Inventor： HEUSLER KARL , BICKEL HANS , FECHTIG BRUNO , PETER HEINRICH , SCARTAZZINI RICCARDO
IPC: C07D501/04 , A61K31/545 , C07D20060101 , C07D501/08 , C07D501/16 , C07D501/20 , A61K27/00 , C07D99/24
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公开(公告)号：NZ212860A
公开(公告)日：1990-03-27
申请号：NZ21286085
申请日：1985-07-24
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , FECHTIG BRUNO , HARTMAN ALBERT , LUKAS BOHUMIR , WACKER OSKAR
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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公开(公告)号：PH23445A
公开(公告)日：1989-08-07
申请号：PH33426
申请日：1986-02-18
Applicant: CIBA GEIGY AG
Inventor： WACKER OSKAR , STANEK JAROSLAV , FECHTIG BRUNO , BASCHANG GERHARD , HARTMANN ALBERT
IPC: C07K9/00
Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R , R and R are, independently of one another, lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino, C1-10-alkoxy, aryl-lower alkoxy, alkanoyloxy-lower alkoxy with up to 16 C atoms, aroyloxy-lower alkoxy, 3-cholesteryloxy or 2-trimethylammonioethyloxy, R is hydrogen, carboxyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, hydroxyl-, lower alkanoylamino-, lower alkanoyloxy-, 2-benzyloxycarbonylaminoethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower-alkoxycarbonyl- aminoethylsulphinyl-, 2-lower-alkoxycarbonylaminoethylsulphonyl- or guanidino-substituted lower alkyl, with the proviso that at least one of the radicals R and R is different from hydroxyl, amino and C1-7-alkoxy or R is different from hydrogen, carboxyl and alkoxycarbonyl with up to 7 C atoms in the alkoxy moiety, and these compounds and salts thereof where appropriate can be used for the prophylaxis and therapy of viral infections.
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公开(公告)号：DD247680A5
公开(公告)日：1987-07-15
申请号：DD27888185
申请日：1985-07-23
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , FECHTIG BRUNO , HARTMANN ALBERT , LUKAS BOHUMIR , WACKER OSKAR
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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