公开(公告)号：DE1160442B

公开(公告)日：1964-01-02

申请号：DED0034117

申请日：1960-02-18

Applicant: DEGUSSA

Inventor： SCHULER DR WILHELM A ,  BESCHKE HELMUT ,  SCHLICHTEGROLL DR ANSGAR V

IPC: C07D417/06 ,  C07D513/04

Abstract: The invention comprises compounds of the general formula (wherein R1 represents hydrogen, chlorine, bromine or a trihalomethyl group, Alk represents a straight or branched alkylene chain of 1-4 carbon atoms, and R2 represents a C1-4 alkyl group or a hydroxyalkyl or acyloxyalkyl group) and their acid addition salts, and the preparation thereof by reacting an appropriate 10-unsubstituted phenthiazine or azaphenthiazine with a compound of the general formula (wherein Hal represents a halogen atom), or reacting a compound of the general formula with a compound of the general formula at elevated temperature, or reacting a compound of the general formula at elevated temperature with a C1-4 alkyl ester, a haloalcohol or an acylated haloalcohol, and in either case, if desired, converting the resulting bases into acid addition salts. The products have anti-emetic and sedative properties.

公开(公告)号：MX154999A

公开(公告)日：1988-01-19

申请号：MX778482

申请日：1982-07-20

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  DAHM FRANZ LUDWIG ,  FRIEDRICH HEINZ

IPC: A61K31/44 ,  C07D213/85

公开(公告)号：IN155430B

公开(公告)日：1985-01-26

申请号：IN647CA1982

申请日：1982-06-05

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  DAHM FRANZ LUDWIG ,  FRIEDRICH HEINZ DR

IPC: C07D213/84 ,  C07D213/85 ,  C07D31/46

Abstract: The gaseous mixture resulting from the catalytic reaction of 3-methylpyridine with ammonia and oxygen is treated with water to recover 3-cyanopyridine. The treatment takes place in two steps. In the first step there is used a temperature of about 30 DEG to 60 DEG C. and in the second step at a temperature about 10 DEG to 30 DEG C. lower than in the first step.

公开(公告)号：CA1169864A

公开(公告)日：1984-06-26

申请号：CA407691

申请日：1982-07-21

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  DAHM FRANZ L ,  FRIEDRICH HEINZ

IPC: C07D213/84 ,  C07D213/85

Abstract: The gaseous mixture resulting from the catalytic reaction of 3-methylpyridine with ammonia and oxygen is treated with water to recover 3-cyanopyridine. The treatment takes place in two steps. In the first step there is used a temperature of about 30 to 60.degree.C and in the second step at a temperature about 10 to 30.degree.C lower than in the first step.

公开(公告)号：CA1164437A

公开(公告)日：1984-03-27

申请号：CA397240

申请日：1982-02-26

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  FRIEDRICH HEINZ ,  HEILOS JOHANNES

IPC: B01J23/16 ,  B01J21/16 ,  B01J23/22 ,  B01J23/34 ,  B01J23/84 ,  B01J23/847 ,  B01J35/10 ,  C07B61/00 ,  C07D213/84 ,  C07D213/85

Abstract: For the catalytic reaction of 3-methyl pyridine with ammonia and oxygen to 3-cyanopyridine catalysts consisting of compounds of the elements antimony, vanadium and oxygen and at least one of the elements iron, copper, titanium, cobalt, manganese and nickel, the atomic ratio of antimony to vanadium being greater than 1, and containing in addition to these compounds layer lattice silicate and highly dispersed silicon dioxide are used. These catalysts are very selective and result in high yields and space time yields.

公开(公告)号：MX5066E

公开(公告)日：1983-03-09

申请号：MX679178

申请日：1978-01-25

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  FRIEDRICH HEINZ

IPC: C07D213/10 ,  B01J21/00 ,  C07B61/00 ,  C07D213/04 ,  C07D213/12

公开(公告)号：DE3128956A1

公开(公告)日：1983-02-10

申请号：DE3128956

申请日：1981-07-22

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  DAHM FRANZ LUDWIG DIPL ING ,  FRIEDRICH HEINZ DR

IPC: C07D213/84 ,  C07D213/85

Abstract: The gaseous mixture resulting from the catalytic reaction of 3-methylpyridine with ammonia and oxygen is treated with water to recover 3-cyanopyridine. The treatment takes place in two steps. In the first step there is used a temperature of about 30 DEG to 60 DEG C. and in the second step at a temperature about 10 DEG to 30 DEG C. lower than in the first step.

公开(公告)号：CH633268A5

公开(公告)日：1982-11-30

申请号：CH81778

申请日：1978-01-25

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  FRIEDRICH HEINZ DR

IPC: C07D213/09 ,  B01J21/00 ,  C07B61/00 ,  C07D213/12

公开(公告)号：CA1136148A

公开(公告)日：1982-11-23

申请号：CA382803

申请日：1981-07-29

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  DAHM FRANZ ,  FRIEDRICH HEINZ ,  PRESCHER GUENTER

IPC: C07D213/82 ,  C07D213/81

Abstract: Crude nicotinamide is purified by a recrystallization and in this way freed especially from nicotinic acid and salts of nicotinic acid. As solvent there is used a 2-methylpropanol-1 containing water. The recrystallization takes place at a pH between about 7 and 10. In this process an outstandingly pure nicotamide is obtained with favorable yield with only a single recrystallization.

公开(公告)号：FR2500829A1

公开(公告)日：1982-09-03

申请号：FR8202967

申请日：1982-02-23

Applicant: DEGUSSA

Inventor： BERGSTEIN WOLFGANG ,  BESCHKE HELMUT ,  FRIEDRICH HEINZ ,  KLEEMANN AXEL ,  PRESCHER GUNTHER

IPC: B01J21/16 ,  B01J23/22 ,  B01J23/34 ,  B01J23/84 ,  B01J35/10 ,  C07B61/00 ,  C07D241/24 ,  B01J21/08 ,  B01J23/16

Abstract: For the catalytic reaction of 2-methylpyrazine with ammonia and oxygen to form 2-cyanopyrazine there are used compounds of the elements antimony, vanadium, and oxygen and at least one of the elements iron, copper, titanium, cobalt, manganese, and nickel, whereby the atomic ratio of antimony to vanadium is greater than 1 and which contain besides these compounds a lattice layer silicate and a highly dispersed silica. These catalysts are very selective and result in high yields and high space-time-yields.