公开(公告)号：CS9103545A3

公开(公告)日：1992-06-17

申请号：CS354591

申请日：1991-11-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  NICKEL WOLF-ULRICH DR

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99 ,  C07D263/04 ,  A61K31/42

CPC classification number: C07D417/04 ,  C07D263/06 ,  C07D417/06

公开(公告)号：DE4023215A1

公开(公告)日：1992-01-23

申请号：DE4023215

申请日：1990-07-21

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD PROF

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.

公开(公告)号：CS9100906A2

公开(公告)日：1991-11-12

申请号：CS90691

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNHARD DR

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：CS9001980A2

公开(公告)日：1991-08-13

申请号：CS198090

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/08

CPC classification number: C07K5/06078 ,  A61K38/00 ,  C07K5/0227

公开(公告)号：CS9001979A2

公开(公告)日：1991-08-13

申请号：CS197990

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  LINZ WOLFGANG DR ,  RUPPERT DIETER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K7/00

CPC classification number: C07K5/06078 ,  A61K38/00

公开(公告)号：DE3924506A1

公开(公告)日：1991-01-31

申请号：DE3924506

申请日：1989-07-25

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJOERG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER DR

IPC: C07C237/08 ,  C07C237/22 ,  C07D233/54 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07K5/065 ,  C07K5/078

Abstract: Peptide polyhydroxyalkylamides of formula (I) and their salts are new; where A = R1R6N-CHR5-CO-, R1R7CH-CHR5-CO- or R1O-CHR5-CO-; R1 = R'1 or R'1W; R'1 = (a) 3-8C cycloalkyl, CONH2, OCH2COOH, NH2, etc. (b) H, OH or 1-4C alkoxy, (c) 1-18C alkyl, quanidino, phenyl(1-4C)alkoxy, etc. (d) 6-14C aryl, (6-14C)aryl(1-4C)alkyl, etc. (e) Het or Het(1-4C)alkyl, where Het is an opt. benzo-fused 5- to 7-membered heterocyclic ring contg. 1 or 2 of N, O, S, No, etc. (f) NR8R9; Het or Het(1-4C)alkyl, or NR8R9 is a mono- or bicyclic 5- to 12-membered ring system opt. contg. 1 or 2 more N atoms, an S atom or an O atom, opt. substd. by 1-4C alkyl; W = CO, CS, OSO, SO2, SO, NHSO2, NHCO, CHOH or NOH; n = 2-10.

公开(公告)号：DE3627877A1

公开(公告)日：1988-02-04

申请号：DE3627877

申请日：1986-08-16

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: A61K31/415 ,  A61K38/00 ,  C07D233/54 ,  C07D233/64 ,  C07K1/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  A61K37/02 ,  A61K37/64

Abstract: The invention relates to compounds of the formula in which R1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R2, R3 and R4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.