公开(公告)号：DE59004292D1

公开(公告)日：1994-03-03

申请号：DE59004292

申请日：1990-07-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJOERG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER DR DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：CS198090A2

公开(公告)日：1991-08-13

申请号：CS198090

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/08

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and R , R , R and R are as defined in the description, to processes for the preparation thereof, to their use as medicines and to pharmaceutical agents containing them.

公开(公告)号：DK0417698T3

公开(公告)日：1996-07-22

申请号：DK90117400

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG DR ,  HEITSCH HOLGER DR ,  HENNING RAINER DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：DE59010189D1

公开(公告)日：1996-04-18

申请号：DE59010189

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：CS9003688A3

公开(公告)日：1992-02-19

申请号：CS368890

申请日：1990-07-24

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMES WERNER DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07K5/06078 ,  C07K5/06139

公开(公告)号：DE3913290A1

公开(公告)日：1990-10-25

申请号：DE3913290

申请日：1989-04-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  SCHOELKENS BERNWARD DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and R , R , R and R are as defined in the description, to processes for the preparation thereof, to their use as medicines and to pharmaceutical agents containing them.

公开(公告)号：DE3913272A1

公开(公告)日：1990-10-25

申请号：DE3913272

申请日：1989-04-22

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  LINZ WOLFGANG DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG ,  WAGNER ADALBERT DR

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：DE3841520A1

公开(公告)日：1990-06-13

申请号：DE3841520

申请日：1988-12-09

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, X either can be absent or is -O-, -S-, -CF2-, -CO- or -CHR , p and q are, independently of one another, 0, 1, 2, 3 or 4, and R to R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to their use as medicines.

公开(公告)号：DE3827340A1

公开(公告)日：1990-02-15

申请号：DE3827340

申请日：1988-08-12

Applicant: HOECHST AG

Inventor： MOELLING KARIN PROF DR ,  PAESSENS ARNOLD DR ,  KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJOERG DR ,  KOENIG WOLFGANG DR ,  RUPPERT DIETER DR ,  WINKLER IRWIN DR

IPC: C12N9/99 ,  A61K31/69 ,  A61K38/00 ,  A61K38/55 ,  A61P31/12 ,  A61P43/00 ,  C07F5/02 ,  C07K5/04 ,  C07K14/81

Abstract: The invention relates to the use of compounds of the formula I in which A is a radical of the formulae A is absent or is a radical of the formula R , R and R are as defined in the description, and x and y are, independently of one another, -O- or -NR and to the salts thereof for the therapy and prophylaxis of viral diseases, especially diseases caused by HIV.

公开(公告)号：DE3601248A1

公开(公告)日：1987-07-23

申请号：DE3601248

申请日：1986-01-17

Applicant: HOECHST AG

Inventor： BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  WEGMANN HELMUT DR ,  RUPPERT DIETER DR

IPC: C07K14/81 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/27 ,  A61K31/33 ,  A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07D213/40 ,  C07D233/54 ,  C07D233/64 ,  C07D333/00 ,  C07D333/24 ,  C07D401/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/04 ,  C07K1/10