公开(公告)号：CS651989A3

公开(公告)日：1992-05-13

申请号：CS651989

申请日：1987-03-27

Applicant: HOECHST AG

Inventor： HOCK FRANZ DR ,  SCHOLTHOLT JOSEF PROF DR ,  URBACH HANSJORG DR ,  HENNING RAINER DR ,  LERCH ULRICH DR ,  NICKEL WOLF-ULRICH DR ,  RUGER WOLFGANG DR

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07C103/50 ,  C07C103/68

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：CS197990A2

公开(公告)日：1991-08-13

申请号：CS197990

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  LINZ WOLFGANG DR ,  RUPPERT DIETER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K7/00

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：DE4028741A1

公开(公告)日：1991-03-28

申请号：DE4028741

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: N-azacyclic-amino-diol derivs. of formula (I) and their physiologically acceptable salts are new: R1 = gp. of formula (II), (III) or (IV) R6 and R7 = H or (all opt. substd.) 1-21C aliphatic, 3-20C alicyclic, 4-20C alicyclic-aliphatic, 6-12C aromatic, 7-32C araliphatic etc. R7 can also be NH2, OH or (all opt. substd.) mono- or di(1-4C) alkylamino, 6-12C arylsulphonyl or carbamoyl etc. R8 is as for R6 or R7; R9 = H, 1-8C alkyl, 3-8C cycloalkyl (1-4C) alkyl 7-13C aralkyl, etc. R10, R11 and R12 = H or 1-6C alkyl, or R10 + R11 = 2-4C alkandiyl; m and n = 0-3; n and p = 1-4; X = CO, CS, SO2 or SO; Y = (CH2)q-(CR13R14)r, O or S; q = 0-3; r = 0-2; Z = 1-6C opt. branched aliphatic; R13 and R14 = H or 1-6C alkyl; R2 = H, 6-12C aryl, 3-8C cycloalkyl, heteroaryl or heteroaryl (1-4C)alkyl; (hetero)aryl gps. can be substd. by 1 or 2 of halo, OH, 1-4C alkoxy, NH2 (opt. substd. by 1 or 2 1-4C alkyl), CF3 or 1-4C alkyl; R3 = 3-8C cycloalkyl (1-4C) alkyl, or 6-12C aryl (1-4C) alkyl, etc. R4 = 6-12C aryl, 6-12C aryl (1-4C) alkyl, OH or NH2; R5 (CH2)5-CHR15-Het; R15 = H, 1-7C alkyl, OH, N3 or halo; Het = 5-7 membered heterocycle which can be benzo-fused, aromatic or (partly) hydrogenated, contg. 1 or 2 of N, O, S, NO, SO or SO2 as heteroatoms and opt. substd. by 1 or 2 of 1-4C alkyl or alkoxy, allyl, OH, halo, NH2 (opt. substd. by 1 or 2 1-4C alkyl) or CF3; S = 0-4; B = residue of the amino acid H-B-OH, most esp. His or norvaline.

公开(公告)号：DE3830096A1

公开(公告)日：1990-03-15

申请号：DE3830096

申请日：1988-09-03

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  HENNING RAINER DR ,  RUEGER WOLFGANG DR ,  LERCH ULRICH DR ,  URBACH HANSJOERG DR ,  HOCK FRANZ DR ,  WIEMER GABRIELE DR

IPC: A61K31/495 ,  A61P25/00 ,  A61P25/28 ,  C07D241/08 ,  C07D403/04 ,  C07D405/04 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D513/04 ,  C07K1/113 ,  C07K5/06

Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.

公开(公告)号：DK0417698T3

公开(公告)日：1996-07-22

申请号：DK90117400

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG DR ,  HEITSCH HOLGER DR ,  HENNING RAINER DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：DE59010189D1

公开(公告)日：1996-04-18

申请号：DE59010189

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：CS276179B6

公开(公告)日：1992-04-15

申请号：CS212687

申请日：1987-03-27

Applicant: HOECHST AG

Inventor： HOCK FRANZ DR ,  SCHOLTHOLT JOSEF PROF DR ,  URBACH HANSJORG DR ,  HENNING RAINER DR ,  LERCH ULRICH DR ,  NICKEL WOLF-ULRICH DR ,  RUGER WOLFGANG DR

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07C237/00

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：CS212687A3

公开(公告)日：1992-04-15

申请号：CS212687

申请日：1987-03-27

Applicant: HOECHST AG

Inventor： HOCK FRANZ DR ,  SCHOLTHOLT JOSEF PROF DR ,  URBACH HANSJORG DR ,  HENNING RAINER DR ,  LERCH ULRICH DR ,  NICKEL WOLF-ULRICH DR ,  RUGER WOLFGANG DR

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07C233/50 ,  C07C233/68

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：DE3913272A1

公开(公告)日：1990-10-25

申请号：DE3913272

申请日：1989-04-22

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  LINZ WOLFGANG DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG ,  WAGNER ADALBERT DR

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：ES2086341T3

公开(公告)日：1996-07-01

申请号：ES90117400

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJORG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.