公开(公告)号：US20060276697A1

公开(公告)日：2006-12-07

申请号：US11146458

申请日：2005-06-07

Applicant: Joseph Demuth ,  Patrick Treado ,  John Maier ,  Jeffrey Cohen

Inventor： Joseph Demuth ,  Patrick Treado ,  John Maier ,  Jeffrey Cohen

IPC: A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/415 ,  A61B5/418

Abstract: The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.

Abstract translation: 本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。 本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估 的血液成分用于表现出血液光学特性的一个或多个区域。

公开(公告)号：US20060253261A1

公开(公告)日：2006-11-09

申请号：US11484040

申请日：2006-07-11

Applicant: John Maier ,  Patrick Treado ,  Jeffrey Cohen ,  Jason Neiss

Inventor： John Maier ,  Patrick Treado ,  Jeffrey Cohen ,  Jason Neiss

IPC: G06F19/00 ,  A61B5/00

CPC classification number: G01N21/65

Abstract: A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

Abstract translation: 用于确定疾病进展的方法和装置。 确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。 用光照射含有至少一个电池的样品。 收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。 每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。 在多个预定向量空间中分析变换点的分布。 根据分析，对样本的疾病状况进行分类。

公开(公告)号：US20060250613A1

公开(公告)日：2006-11-09

申请号：US11404964

申请日：2006-04-14

Applicant: Joseph Demuth ,  Patrick Treado ,  John Maier ,  David Tuschel

Inventor： Joseph Demuth ,  Patrick Treado ,  John Maier ,  David Tuschel

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/32 ,  G01N21/658

Abstract: A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5×105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

Abstract translation: 一种用于成像生物体的方法和装置。 提供了具有均匀分布在表面上的增强结构的SERS表面。 该表面包括至少5×10 5 nm的二维区域。 增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。 生物材料沉积在SERS表面上。 使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。 使用可调滤波器将拉曼散射光子滤波成多个预定波长带。 二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。 滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

公开(公告)号：US20060203238A1

公开(公告)日：2006-09-14

申请号：US11366532

申请日：2006-03-03

Applicant: Charles Gardner ,  John Maier ,  Matthew Nelson ,  Robert Schweitzer ,  Patrick Treado ,  G. Vanni ,  Julianne Wolfe ,  Joseph Demuth ,  Jason Neiss ,  Chenhui Wang

Inventor： Charles Gardner ,  John Maier ,  Matthew Nelson ,  Robert Schweitzer ,  Patrick Treado ,  G. Vanni ,  Julianne Wolfe ,  Joseph Demuth ,  Jason Neiss ,  Chenhui Wang

IPC: G01J3/44 ,  G01J3/45

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2201/0221

Abstract: The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.

Abstract translation: 本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像 使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

公开(公告)号：US20060158645A1

公开(公告)日：2006-07-20

申请号：US11336588

申请日：2006-01-20

Applicant: John Maier ,  Patrick Treado

Inventor： John Maier ,  Patrick Treado

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/2823 ,  G01N21/65 ,  G01N2021/1787

Abstract: A method for measuring spatial and spectral information from a sample using computed tomography imaging spectroscopy. An area of the sample is illuminated using an illumination source having substantially monochromatic light. Raman scattered light is directed from said illuminated area of said sample onto a two dimensional grating disperser. Light output, from the two dimensional grating disperser, is directed onto a detector that detects a dispersed image. The dispersed image from the detector is applied to a processing algorithm that generates a plurality of spatially accurate, wavelength resolved images of the sample.

Abstract translation: 一种使用计算机断层摄影成像光谱从样本测量空间和光谱信息的方法。 使用具有基本上单色光的照明源照射样品的区域。 拉曼散射光从所述样品的所述照射区域引导到二维光栅分散器上。 来自二维光栅分散器的光输出被引导到检测器，其检测分散的图像。 来自检测器的分散图像被应用于产生样本的多个空间准确的波长分辨图像的处理算法。

公开(公告)号：US20060116206A1

公开(公告)日：2006-06-01

申请号：US10516709

申请日：2003-12-24

Applicant: Matthew Nelson ,  Patrick Treado ,  Jason Attanucci

Inventor： Matthew Nelson ,  Patrick Treado ,  Jason Attanucci

IPC: A63F13/00

CPC classification number: A63F13/35 ,  A63F13/12 ,  A63F13/335 ,  A63F13/798 ,  A63F2300/572

Abstract: A game machine 1 is provided with progress state controlling means 21 for storing and controlling a state of a progress of a story in a game for each player, player identification means 15 for identifying the player on the basis of an origin of a received mail received through a receiving server 12, instruction obtaining means 16 for analyzing contents of a sentence of the received mail so as to obtain as instruction information, story processing means 18 for judging the state of the progress of the story corresponding to the player identified and for processing a development of the story in the game on the basis of the judged state of progress and the instruction information, reply mail preparing means 19 for preparing a reply mail for sending information in response to the instruction information on the basis of the processed development of the story, and reply mail processing means 20 for sending the prepared reply mail to the identified player through the server 13.

Abstract translation: 游戏机1设置有用于存储和控制每个玩家的游戏中的故事进展状态的进度状态控制装置21，用于基于收到的接收邮件的来源识别玩家的玩家识别装置15 通过接收服务器12，用于分析接收到的邮件的句子的内容以获得作为指示信息的指令获取装置16，用于判断与所识别的玩家相对应的故事的进度状态的故事处理装置18和用于处理 基于判定的进展状态和指示信息，在游戏中发展故事;回复邮件准备装置19，用于根据处理的发展情况，根据指令信息准备用于发送信息的回复邮件 故事和回复邮件处理装置20，用于通过服务器13将准备的回复邮件发送到所识别的玩家。

公开(公告)号：US20050052645A1

公开(公告)日：2005-03-10

申请号：US10922006

申请日：2004-08-18

Applicant: Shona Stewart ,  John Maier ,  Patrick Treado

Inventor： Shona Stewart ,  John Maier ,  Patrick Treado

IPC: C12Q1/04 ,  G01N21/31 ,  G01N21/64 ,  G01N21/65 ,  G01J3/44

CPC classification number: G01N21/6486 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/31 ,  G01N21/33 ,  G01N21/359 ,  G01N21/645 ,  G01N21/6456 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/1736 ,  G01N2021/6421 ,  G01N2021/6423 ,  G01N2021/656

Abstract: Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.

公开(公告)号：US20050030533A1

公开(公告)日：2005-02-10

申请号：US10893339

申请日：2004-07-19

Applicant: Patrick Treado

Inventor： Patrick Treado

IPC: G01B9/02 ,  G01J20060101 ,  G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01J3/30 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65 ,  G02F1/1333 ,  G02F1/1335 ,  G02F1/1347

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6471 ,  G01N2201/0221 ,  G01N2201/0627 ,  G02F1/133371 ,  G02F1/1347

Abstract: The disclosure generally relates to a method and apparatus for compact dispersive imaging spectrometer. More specifically, one embodiment of the disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension. The portable system can include a photon emission source for sequentially illuminating a plurality of portions of said sample with a plurality of photons to produce photons scattered by the sample. The photon emission source can illuminate the sample along the first spatial dimension for each of plural predetermined positions of the second spatial dimension. The system may also include an optical lens for collecting the scattered photons to produce therefrom filtered photons, a dispersive spectrometer for determining a wavelength of ones of the filtered photons, a photon detector for receiving the filtered photons and obtaining therefrom plural spectra of said sample, and a processor for producing a two dimensional image of said sample from the plural spectra.

Abstract translation: 本发明一般涉及紧凑型分散成像光谱仪的方法和装置。 更具体地，本公开的一个实施例涉及用于获得具有第一和第二空间维度的样本的空间上准确的波长分辨图像的便携式系统。 便携式系统可以包括光子发射源，用于用多个光子顺序照射所述样品的多个部分，以产生由样品散射的光子。 光子发射源可以沿着第一空间维度对第二空间维度的多个预定位置中的每一个照射样本。 该系统还可以包括用于收集散射光子以产生滤光光子的光学透镜，用于确定滤光光子中波长的波长的色散光谱仪，用于接收经滤光的光子并由此获得所述样品的多个光谱的光子检测器， 以及用于从所述多个光谱产生所述样本的二维图像的处理器。

公开(公告)号：US6002476A

公开(公告)日：1999-12-14

申请号：US64347

申请日：1998-04-22

Applicant: Patrick Treado

Inventor： Patrick Treado

IPC: G01J3/44

CPC classification number: G01J3/44

Abstract: A Raman chemical imaging system uses a laser illumination source for illuminating an area of a sample. The spectrum of scattered light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. An Evans Split-Element type liquid crystal tunable filter (LCTF) selects a Raman image of the collimated beam. A detector collects the filtered Raman images which are subsequently processed to determine the constituent materials. The Evans Split-Element-type LCTF suitable for high-definition Raman chemical imaging is incorporated into an efficient Raman imaging system that provides significant performance advantages relative to any previous approach to Raman microscopy. The LCTF and associated optical path is physically compact, which accommodates integration of the LCTF within an infinity-corrected optical microscope. The LCTF simultaneously provides diffraction-limited spatial resolution and 9 cm.sup.-1 spectral bandpass across the full free spectral range of the imaging spectrometer. The LCTF Raman microscope successfully integrates the utility of optical imaging and the analytical capabilities of Raman spectroscopy which has practical significance in materials analysis, including the diagnosis of cancer.

Abstract translation: 拉曼化学成像系统使用激光照射源来照射样品的区域。 收集来自样品的照射区域的散射光的光谱，并从其中产生准直光束。 Evans分离元件型液晶可调滤波器（LCTF）选择准直光束的拉曼图像。 检测器收集随后被处理以确定构成材料的经过滤的拉曼图像。 适用于高清晰度拉曼化学成像的Evans Split-Element型LCTF被纳入一个有效的拉曼成像系统中，相对于任何以前的拉曼显微镜方法，其具有显着的性能优势。 LCTF和相关的光路物理紧凑，可以将LCTF集成在无穷远校正的光学显微镜内。 LCTF同时在成像光谱仪的完整自由光谱范围内提供衍射极限空间分辨率和9 cm -1光谱带通。 LCTF拉曼显微镜成功整合了光学成像的实用性和拉曼光谱分析能力，在材料分析，包括癌症诊断中具有现实意义。