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公开(公告)号：US20060268266A1
公开(公告)日：2006-11-30
申请号：US11366660
申请日：2006-03-03
Applicant: Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
Inventor： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
CPC classification number: G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
Abstract: The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
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公开(公告)号：US07045757B1
公开(公告)日：2006-05-16
申请号：US11097161
申请日：2005-04-04
Applicant: David Tuschel , John Maier , Joseph Demuth
Inventor： David Tuschel , John Maier , Joseph Demuth
IPC: H01L27/00
CPC classification number: G01N21/6428 , G01J3/02 , G01J3/027 , G01J3/10 , G01N21/65 , G01N2021/6417 , G01N2021/6471 , G01N2201/067
Abstract: In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.
Abstract translation: 在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。
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公开(公告)号：US07522797B2
公开(公告)日：2009-04-21
申请号：US11798483
申请日：2007-05-14
Applicant: Patrick Treado , Matthew Nelson , Joseph Demuth
Inventor： Patrick Treado , Matthew Nelson , Joseph Demuth
CPC classification number: A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/33 , G01N21/359 , G01N21/474 , G01N21/645 , G01N21/65 , G01N2021/3155 , G01N2021/4742 , G01N2021/6419 , G01N2021/6421 , G01N2021/6484 , G01N2021/656 , G02B6/06 , G02B6/29398 , G02B23/2423 , G02B23/2469
Abstract: The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.
Abstract translation: 本发明一般涉及一种纤维镜的方法和装置。 在一个实施例中，本公开涉及一种用于从具有至少一个照明光纤的样品成像和收集光谱的化学成像光纤镜，用于将光从第一光源传输到第二光源到光纤镜的远端; 分光镜，设置在所述纤维内窥镜的所述远端处，使得来自所述第一光源的光基本上直通所述镜，并且来自所述第二光源的预定波长的光被所述反射镜基本上反射到所述样品，从而照亮所述样品 ; 以及至少一个收集光纤，用于接收来自所述照明样品的光并将接收到的光发射到光学装置。
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公开(公告)号：US20070008525A1
公开(公告)日：2007-01-11
申请号：US11520348
申请日：2006-09-13
Applicant: David Tuschel , Patrick Treado , Joseph Demuth
Inventor： David Tuschel , Patrick Treado , Joseph Demuth
IPC: G01J3/44
CPC classification number: G01J3/44 , G01J3/28 , G01N21/274 , G01N21/6489 , G01N21/65
Abstract: An ion implanted semiconductor surface is illuminated with a flood illumination of monochromatic radiation, and an image of the surface is taken using light which has been Raman scattered. The illumination and imaging system are calibrated by flood illuminating a uniformly Raman scattering surface.
Abstract translation: 用单色辐射的泛光照射照射离子注入的半导体表面，并且使用已经被拉曼散射的光进行表面的图像。 照明和成像系统通过泛光照射均匀的拉曼散射表面来校准。
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公开(公告)号：US20060276697A1
公开(公告)日：2006-12-07
申请号：US11146458
申请日：2005-06-07
Applicant: Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
Inventor： Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
IPC: A61B5/00
CPC classification number: A61B5/14546 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418
Abstract: The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.
Abstract translation: 本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。 本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估 的血液成分用于表现出血液光学特性的一个或多个区域。
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Patent Agency Ranking
6.发明申请Method and applications to enhance and image optical signals from biological objects 审中-公开从生物对象增强和成像光信号的方法和应用公开(公告)号：US20060250613A1
公开(公告)日：2006-11-09
申请号：US11404964
申请日：2006-04-14
Applicant: Joseph Demuth , Patrick Treado , John Maier , David Tuschel
Inventor： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
CPC classification number: G01J3/44 , G01J3/32 , G01N21/658
Abstract: A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5×105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.
Abstract translation: 一种用于成像生物体的方法和装置。 提供了具有均匀分布在表面上的增强结构的SERS表面。 该表面包括至少5×10 5 nm的二维区域。 增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。 生物材料沉积在SERS表面上。 使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。 使用可调滤波器将拉曼散射光子滤波成多个预定波长带。 二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。 滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。
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7.发明申请Method and apparatus for compact spectrometer for detecting hazardous agents 有权用于检测危险物质的紧凑型光谱仪的方法和装置公开(公告)号：US20060203238A1
公开(公告)日：2006-09-14
申请号：US11366532
申请日：2006-03-03
Applicant: Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
Inventor： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
CPC classification number: G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2201/0221
Abstract: The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
Abstract translation: 本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像 使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。
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公开(公告)号：US20100262378A1
公开(公告)日：2010-10-14
申请号：US12755463
申请日：2010-06-23
Applicant: John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
Inventor： John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
CPC classification number: A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/415 , A61B5/417 , A61B5/418 , A61B5/4519 , G01N21/65
Abstract: A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.
Abstract translation: 一种产生样品图像的方法，其用于提供样品中细胞的疾病状态。 用单色光照射包含电池的样品。 评估拉曼散射光。 产生拉曼散射光的数字明场图像，并与细胞发射的拉曼散射光组合，由此拉曼散射光提供样品中细胞的疾病状态。 该方法还可以用于确定细胞的代谢活性，细胞的炎性状态和/或样品中细胞的感染状态。
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公开(公告)号：US20070280612A1
公开(公告)日：2007-12-06
申请号：US11798483
申请日：2007-05-14
Applicant: Patrick Treado , Matthew Nelson , Joseph Demuth
Inventor： Patrick Treado , Matthew Nelson , Joseph Demuth
CPC classification number: A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/33 , G01N21/359 , G01N21/474 , G01N21/645 , G01N21/65 , G01N2021/3155 , G01N2021/4742 , G01N2021/6419 , G01N2021/6421 , G01N2021/6484 , G01N2021/656 , G02B6/06 , G02B6/29398 , G02B23/2423 , G02B23/2469
Abstract: The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.
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10.发明申请Method and apparatus for compact spectrometer for fiber array spectral translator 有权用于光纤阵列光谱转换器的紧凑型光谱仪的方法和装置公开(公告)号：US20060209301A1
公开(公告)日：2006-09-21
申请号：US11366531
申请日：2006-03-03
Applicant: Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
Inventor： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
CPC classification number: G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
Abstract: The disclosure relates to a portable system having a fiber array spectral translator (“FAST”) for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
Abstract translation: 本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质 具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。
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