公开(公告)号：ZA200205599B

公开(公告)日：2003-12-01

申请号：ZA200205599

申请日：2002-07-12

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC-DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  C07D ,  A61K ,  A61P

Abstract: Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH 2 or R 1 and R 2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R 3 and R 4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.

公开(公告)号：SI1252150T1

公开(公告)日：2003-10-31

申请号：SI200130014

申请日：2001-02-01

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC-DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/4353 ,  A61P3/06 ,  A61P3/10 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04

公开(公告)号：AR030048A1

公开(公告)日：2003-08-13

申请号：ARP010100496

申请日：2001-02-02

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUME D ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4353

Abstract: Derivados heterocíclicos de formula 1 en la cual A, B, D, X, R1, R2, R3 y R4 son tal como se definen en la descripcion, sus enantiomeros y diastereoisomeros así como sus sales de adicion con un ácido o con una base farmacéuticamente aceptables; procedimiento para prepararlos y composiciones farmacéuticas que los contienen. Los derivados heterocíclicos de formula 1 son utiles para el tratamiento y/o la profilaxis de la hiperglucemias, de las dislipidemias y más particularmente en el tratamiento de las diabetes no insulinodependientes del tipo II, de la resistencia a la insulina, de la tolerancia a la glucosa, de los desordenes relacionados con el síndrome X, de las enfermedades arteriales coronarias y otras enfermedades cardiovasculares, de las enfermedades renales, de las retinopatías, de los desordenes relacionados con la activacion de las células endoteliales, de la psoriasis, del síndrome poliquístico de ovario, de la demencia, de la osteoporosis, de las enfermedades inflamatorias intestinales, de las distrofias miotonicas, de las pancreatitis, de la arterioesclerosis, del xantoma, pero también en el tratamiento o la prevencion de la diabetes de tipo I, de la obesidad, de la regulacion del apetito, de la anorexia, de la bulimia, de la anorexia nerviosa, así como de las patologías cancerosas y en especial de los cánceres hormonodependientes tales como el cáncer de pecho y el cáncer de colon, y como inhibidores de angiogénesis.

公开(公告)号：FR2821843B1

公开(公告)日：2003-05-09

申请号：FR0103293

申请日：2001-03-12

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/404

Abstract: Compound of formula (I):wherein:R1, R2, R3, R4, R5, R6 and R8, which may be identical or different, each represents hydrogen, alkyl, arylalkyl, hydroxy, alkoxy, arylalkoxy, acyloxy, arylcarbonyloxy, carboxyalkyl or carboxy,R7 represents hydrogen, hydroxy, alkoxy, arylalkoxy, acyloxy or arylcarbonyloxy group,or one of R1 to R8, together with another of R1 to R8 adjacent to it, forms an alkylenedioxy,its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

公开(公告)号：DE60001190D1

公开(公告)日：2003-02-20

申请号：DE60001190

申请日：2000-04-14

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  DUHAULT JACQUES ,  BOUTIN JEAN ALBERT ,  LEVENS NIGEL

IPC: C07D249/08 ,  A61K31/4196 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/501 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/12 ,  A61P15/00 ,  A61P15/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/12 ,  C07D249/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: 1,2,4-Triazolylamino-substituted carboxamide or hydrazide derivatives (I) are new. Triazole derivatives of formula G-NH-A- CO-NH-(NH)n-W-Z (I) and their enantiomers, diastereoisomers and acid or base addition salts are new. G = 1,2,4-triazolyl group of formula (G1)-(G4); n = 0 or 1; W = CO, S, SO or SO2; Z, R1 = alkyl or (all optionally substituted) aryl, heteroaryl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl or heteroaralkynyl; A = -A2-, -A1-A-2-, -A2-A1- or -A1-A2-A1-; A1 = alkylene; A2 = phenylene, naphthylene, cycloalkylene or heteroarylene (all optionally substituted); R = H or as Z. Alkyl or alkylene groups have 1-6C; alkenyl/alkynyl groups have 2-6C and 1-3 double/triple bonds; cycloalkylene groups have 3-6C; aryl groups are phenyl, naphthyl, biphenylyl, dihydronaphthyl or tetrahydronaphthyl; heteroaryl moieties are 5-11 membered, mono- or bicyclic and unsaturated or partially unsaturated, and contain 1-4 of O, S and N as heteroatoms; arylene or heteroarylene moieties are the divalent analogs of arylene and heteroarylene respectively; optionally substituted, in the case of aryl, aralkyl, heteroaryl and heteroaralkyl, indicates that the groups are optionall ring-substituted by 1-5 of alkyl, alkoxy, halo, OH, perhaloalkyl, NO2, NH2, mono- or dialkylamino, 1-6C acyl, CONH2, mono- or di-alkylaminocarbonyl, 1-6C acylamino, alkoxycarbonyl, CHO, COOH, SO3H, CN, aminoalkyl, mono- or dialkylaminoalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl; optionally substituted, in the case of phenylene, naphthylene and heteroarylene, indicates that the groups are optionally substituted by 1-3 of alkyl, alkoxy, halo, OH, perhaloalkyl, NO2, NH2, mono- or dialkylamino, 1-6C acyl, CHO, COOH, alkoxycarbonyl, CONH2, mono- or di-alkylaminocarbonyl, 1-6C acylamino or CN. An Independent claim is included for the preparation of (I).

公开(公告)号：AT231133T

公开(公告)日：2003-02-15

申请号：AT00401039

申请日：2000-04-14

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  DUHAULT JACQUES ,  BOUTIN JEAN ALBERT ,  LEVENS NIGEL

IPC: C07D249/08 ,  A61K31/4196 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/501 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/12 ,  A61P15/00 ,  A61P15/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/12 ,  C07D249/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: 1,2,4-Triazolylamino-substituted carboxamide or hydrazide derivatives (I) are new. Triazole derivatives of formula G-NH-A- CO-NH-(NH)n-W-Z (I) and their enantiomers, diastereoisomers and acid or base addition salts are new. G = 1,2,4-triazolyl group of formula (G1)-(G4); n = 0 or 1; W = CO, S, SO or SO2; Z, R1 = alkyl or (all optionally substituted) aryl, heteroaryl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl or heteroaralkynyl; A = -A2-, -A1-A-2-, -A2-A1- or -A1-A2-A1-; A1 = alkylene; A2 = phenylene, naphthylene, cycloalkylene or heteroarylene (all optionally substituted); R = H or as Z. Alkyl or alkylene groups have 1-6C; alkenyl/alkynyl groups have 2-6C and 1-3 double/triple bonds; cycloalkylene groups have 3-6C; aryl groups are phenyl, naphthyl, biphenylyl, dihydronaphthyl or tetrahydronaphthyl; heteroaryl moieties are 5-11 membered, mono- or bicyclic and unsaturated or partially unsaturated, and contain 1-4 of O, S and N as heteroatoms; arylene or heteroarylene moieties are the divalent analogs of arylene and heteroarylene respectively; optionally substituted, in the case of aryl, aralkyl, heteroaryl and heteroaralkyl, indicates that the groups are optionall ring-substituted by 1-5 of alkyl, alkoxy, halo, OH, perhaloalkyl, NO2, NH2, mono- or dialkylamino, 1-6C acyl, CONH2, mono- or di-alkylaminocarbonyl, 1-6C acylamino, alkoxycarbonyl, CHO, COOH, SO3H, CN, aminoalkyl, mono- or dialkylaminoalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl; optionally substituted, in the case of phenylene, naphthylene and heteroarylene, indicates that the groups are optionally substituted by 1-3 of alkyl, alkoxy, halo, OH, perhaloalkyl, NO2, NH2, mono- or dialkylamino, 1-6C acyl, CHO, COOH, alkoxycarbonyl, CONH2, mono- or di-alkylaminocarbonyl, 1-6C acylamino or CN. An Independent claim is included for the preparation of (I).

公开(公告)号：ZA200202030B

公开(公告)日：2002-10-03

申请号：ZA200202030

申请日：2002-03-12

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  C07D ,  A61K ,  A61P

Abstract: Compound of formula (I):wherein:R1, R2, R3, R4, R5, R6 and R8, which may be identical or different, each represents hydrogen, alkyl, arylalkyl, hydroxy, alkoxy, arylalkoxy, acyloxy, arylcarbonyloxy, carboxyalkyl or carboxy,R7 represents hydrogen, hydroxy, alkoxy, arylalkoxy, acyloxy or arylcarbonyloxy group,or one of R1 to R8, together with another of R1 to R8 adjacent to it, forms an alkylenedioxy,its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

公开(公告)号：NO20021330L

公开(公告)日：2002-09-20

申请号：NO20021330

申请日：2002-03-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  C07D209/58

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.

公开(公告)号：NO20021330A

公开(公告)日：2002-09-20

申请号：NO20021330

申请日：2002-03-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  C07D209/58

CPC classification number: C07D209/80 ,  A61K31/40

公开(公告)号：NO20021198A

公开(公告)日：2002-09-13

申请号：NO20021198

申请日：2002-03-11

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/04 ,  C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/46 ,  A61K31/4035

CPC classification number: C07D487/04