Abstract:
PROBLEM TO BE SOLVED: To provide a microscopy imaging system which provides improved sensitivity and specificity. SOLUTION: This microscopy imaging system includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components, such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of object from the sample. The modulator system is for modulating the property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting the integrated intensity of substantially all optical frequency components of the train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting the modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-linear interaction of the shaped first train of pulses, with the second train of pulses as being modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system. COPYRIGHT: (C)2010,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a spectral composition of illumination light and/or sample light and/or a method and arrangement for changing intensity under control. SOLUTION: The method includes a step for performing spacial separation to a beam component having a different polarization by a first polarizing means (Pol 1); a step for performing spectral spacial division of at least one beam component by a first dispersing means (Disp 1); a step for changing at least a partial polarizing state of the beam component divided in a spectral space; and a step for performing the spacial separation and/or spacial collection of the beam component having different polarization by a second polarizing means (Pol 2). In the spectral composition of the illumination light and/or the sample light, and the method for changing the intensity under the control, the spacial collection of the beam component the polarizing state of which is changed or not changed is performed by the second polarizing means (Disp 2) desirable in the case. COPYRIGHT: (C)2004,JPO
Abstract:
A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-lincar interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system.
Abstract:
PROBLEM TO BE SOLVED: To provide a light irradiation device for radiating light having a desired spectrum and at the same time with controlled directivity. SOLUTION: The light irradiation device 100 includes: a light source 101; a light guide body 107; and a member for spectrum modulation 104. In this case, the light guide body 107 guides the light made incident from a light source 101 inside from a surface of incidence and emits the light with controlled directivity from an emission surface by having the light reflected on a side surface of the light guide body 107. In addition, the member for spectrum modulation 104 has the spectrum in a specific wavelength band decayed in the light with controlled directivity. Moreover, the incidence surface is smaller than the emission surface in the light guide body 107 and the member for spectrum modulation 104 is equipped on the emission surface side of the light guide body 107. COPYRIGHT: (C)2011,JPO&INPIT
Abstract:
A spectroscope designed to utilize an adaptive optical element such as a micro mirror array (MMA) and two distinct light channels and detectors. The devices can provide for real-time and near real-time scaling and normalization of signals.