公开(公告)号：US07928408B2

公开(公告)日：2011-04-19

申请号：US11345262

申请日：2006-02-01

Applicant: Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

Inventor： Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

IPC: G01N21/64

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。

公开(公告)号：US06796697B1

公开(公告)日：2004-09-28

申请号：US10140486

申请日：2002-05-07

Applicant: Chris Bragg ,  Daniel Scott ,  Eliezer Rosengaus

Inventor： Chris Bragg ,  Daniel Scott ,  Eliezer Rosengaus

IPC: F21V704

CPC classification number: G02B6/02 ,  G01N21/8806 ,  G01N21/9501 ,  G01N21/956 ,  G01N2021/8812 ,  G01N2201/0631 ,  G01N2201/0635 ,  G01N2201/0638 ,  G01N2201/0806 ,  G01N2201/0826 ,  G02B5/0252 ,  G02B5/32 ,  G02B6/04 ,  G02B6/4298

Abstract: An illumination delivery system provides a spatially and angularly uniform shaped beam output with sufficient intensity to illuminate a sample surface for defect inspection. Light is transmitted through a shaped fiber optic bundle, a homogenizer, a diffuser, and an optional focusing optics system.

Abstract translation: 照明传送系统提供具有足够强度的空间和角度均匀成形的光束输出，以照射样品表面进行缺陷检查。 光通过成形的光纤束，均质器，扩散器和可选的聚焦光学系统传输。

公开(公告)号：US06396581B1

公开(公告)日：2002-05-28

申请号：US09492302

申请日：2000-01-27

Applicant: Toshinori Hayashi ,  Takahiko Ishiguro

Inventor： Toshinori Hayashi ,  Takahiko Ishiguro

IPC: G01N2164

CPC classification number: G01N21/645 ,  G01N21/253 ,  G01N35/025 ,  G01N2201/0231 ,  G01N2201/0423 ,  G01N2201/043 ,  G01N2201/0806 ,  G01N2201/0853

Abstract: A fluorescence detection apparatus is provided which comprises a sample holder for holding stationarily sample vessels deployed along a circle line or concentric circle lines having different radiuses, a partition plate connected to a driving means to be rotatable around the center of the circle line or concentric circle lines, an optical means for excitation light and an optical means for fluorescence light fixed respectively to the partition plate to be rotatable in integration therewith, a first light guide constituted of numerous optical fibers, a photosensor, and a light source for generating the excitation light, wherein the partition plate, the optical means for excitation light, and the optical means for fluorescence are integrally rotated, and thereby the fluorescence of the sample arranged along the circle line is successively detected and the detected fluorescence is transmitted to the photosensor. This fluorescence detection apparatus is useful in real-time monitoring of fluorescence signals, and satisfies the requirements of precise temperature control, quick treatment of many samples, high sensitivity, high reliability, low cost, and small size of the apparatus.

Abstract translation: 提供了一种荧光检测装置，其包括用于保持沿着圆线展开的固定样品容器的样本保持器或具有不同半径的同心圆线，连接到驱动装置的分隔板，以可围绕圆线或同心圆的中心旋转 线路，用于激发光的光学装置和用于荧光的光学装置分别固定在分隔板上以使其一体旋转;由多个光纤构成的第一导光体，光电传感器和用于产生激发光的光源 其中分隔板，用于激发光的光学装置和用于荧光的光学装置一体地旋转，从而连续检测沿着圆线排列的样品的荧光，并将检测到的荧光传输到光电传感器。 该荧光检测装置可用于实时监测荧光信号，满足精密温度控制，快速处理多种样品，高灵敏度，高可靠性，低成本，体积小的要求。

公开(公告)号：US4929084A

公开(公告)日：1990-05-29

申请号：US300936

申请日：1989-01-24

Applicant: Fred Mast ,  Jean A. Knus

Inventor： Fred Mast ,  Jean A. Knus

IPC: G01J3/02 ,  G01J3/50 ,  G01N21/47 ,  G02B19/00

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0297 ,  G01N21/474 ,  G02B19/0028 ,  G02B19/0085 ,  G01J3/1838 ,  G01N2021/4757 ,  G01N2201/0806

Abstract: A measuring head, in particular a manual device for the determination of photometric data, includes an optical illuminating device with an aspherical mirror having a groove which extends in an annular manner around an axis of rotational symmetry of the groove, and which, in cross-section, has the configuration of an elliptical segment. The measuring optics to detect the light reflected from a measuring spot forms a round measuring spot on an ellipse at the inlet slit of a monochromator, for which a spherical/cylindrical lens, a first glass rod and a second glass rod are used, the glass rods being provided with cylindrical surfaces, the associated cylinder axes of which are crossed with each other.

Abstract translation: 测量头，特别是用于确定测光数据的手动装置包括具有非球面镜的光学照明装置，该非球面镜具有围绕凹槽的旋转对称轴线以环形方式延伸的凹槽， 截面，具有椭圆形段的配置。 用于检测从测量点反射的光的测量光学元件在单色仪的入口狭缝处形成圆形测量点，其中使用球形/柱面透镜，第一玻璃棒和第二玻璃棒，玻璃 杆设置有圆柱形表面，其相关联的圆柱轴线彼此交叉。

公开(公告)号：US4891519A

公开(公告)日：1990-01-02

申请号：US257635

申请日：1988-10-14

Applicant: Tadashi Nohira ,  Tsuneo Imatsu ,  Ikuzo Kagami

Inventor： Tadashi Nohira ,  Tsuneo Imatsu ,  Ikuzo Kagami

IPC: G01J1/44 ,  G01J1/16 ,  G01N21/01 ,  G01N21/53 ,  G01N21/59 ,  G01N21/85

CPC classification number: G01N21/534 ,  G01N21/8507 ,  G01J1/1626 ,  G01J2001/444 ,  G01N2201/0612 ,  G01N2201/0806

Abstract: A turbidimeter for measuring a turbidity of a test liquid including a hollow main body having openings formed at its lower end through which the test liquid is introduced into a measuring optical path within the main body, a semiconductor laser diode arranged in the main body at its upper end and emitting a laser light, a first prism arranged within the main body and guiding the laser light into the measuring optical path, a second prism arranged within the main body and guiding light emanating from the measuring optical path to the upper end of the main body, first and second semiconductor photodiodes arranged within the main body at its upper end such that the light emanating from the second prism is exclusively made incident upon the first semiconductor photodiode, and first and second operational amplifiers arranged within the main body at its upper end and amplifying output signals supplied from the first and second semiconductor photodiodes, respectively. Output signals generated from the first and second operational amplifiers are supplied to a differential amplifier to derive a difference therebetween, the difference corresponding to the turbidity of the test liquid. The differential amplifier is arranged remote from the main body, so that any error in the measured turbidity due to the temperature variation can be compensated for.

Abstract translation: 一种浊度计，用于测量包括中空主体的测试液体的浊度，所述中空主体在其下端形成开口，所述测试液体通过所述开口被引入到所述主体内的测量光路中;半导体激光二极管，其设置在所述主体中 上端并发射激光，第一棱镜布置在主体内并将激光引导到测量光路中，第二棱镜布置在主体内，并将从测量光路发出的光引导到测量光路的上端 主体，第一和第二半导体光电二极管，其上端设置在主体内，使得从第二棱镜发出的光仅专门入射在第一半导体光电二极管上，第一和第二运算放大器布置在主体的上部 分别结束和放大从第一和第二半导体光电二极管提供的输出信号。 从第一和第二运算放大器产生的输出信号被提供给差分放大器以导出它们之间的差异，该差值对应于测试液体的浊度。 差分放大器远离主体布置，可以补偿由于温度变化引起的测量浊度的任何误差。

公开(公告)号：US4775794A

公开(公告)日：1988-10-04

申请号：US115314

申请日：1987-11-02

Applicant: Henry Behmann

Inventor： Henry Behmann

IPC: G01J1/16 ,  G01J1/44 ,  G01N21/31 ,  G01N21/33 ,  G01N33/18 ,  G01J1/42

CPC classification number: G01N33/1826 ,  G01N21/33 ,  G01J2001/1636 ,  G01J2001/4433 ,  G01N2021/3155 ,  G01N2021/3166 ,  G01N2201/0696 ,  G01N2201/0806

Abstract: The invention provides a new method and apparatus for measuring the concentration of ultra-violet light absorbing organic materials liquids, particularly in pure or ultra-pure water, the speed and convenience being such that it is possible to take successive readings with periods as short as ten seconds. The apparatus can be mounted directly in or as a by-pass to a process stream, giving the capability of constant monitoring with virtually instant microprocessor-controlled response to measurements outside a pre-set range. The water to be measured passes upwards in a cylindrical opaque-walled sample cell at the upper end of which is mounted an intense light source, preferably a Xenon flash tube, and at the lower end of which is mounted two transmission photodetectors, which have in front of them respective narrow-band optical transmission filters in the ultra-violet and visible regions. The light source sits on the upper end of a quartz rod which extends into the cell at or below the water inlet and is coaxial with the cell longitudinal axis, the rod serving to direct the light toward the transmission photodetectors. The output from the "visible" photodetector is used to correct the output from the "ultraviolet" photodetector for transmission losses caused by particulates, element fouling and bubbles in the stream. Two reference photodetectors employing two similar transmission filters are disposed close to the flash tube outlet window and their signals are used to correct for variation in the flash tube output.

Abstract translation: 本发明提供了一种用于测量紫外光吸收有机材料液体的浓度的新方法和装置，特别是在纯净或超纯水中，其速度和方便性使得可以连续读数， 十秒钟。 该设备可以直接安装在旁路旁边或作为旁路安装到过程流中，从而能够以预定范围外的测量实际上对微处理器控制的响应进行持续监控。 要测量的水在圆柱形不透明壁样品池中向上通过，其上端安装有强光源，优选氙闪光管，并且其下端安装有两个透射光电检测器，其具有 在它们的前面分别在紫外和可见区域的窄带光传输滤波器。 光源位于石英棒的上端，该石英棒在水入口处或其下方延伸到电池中，并且与电池纵向轴线同轴，该杆用于将光引向透射光电检测器。 来自“可见”光电探测器的输出用于校正“紫外”光电检测器的输出，用于由流中的微粒，元素结垢和气泡引起的传输损失。 使用两个类似的透射滤光器的两个参考光电检测器设置在闪光管出口窗口附近，并且它们的信号用于校正闪光管输出的变化。

公开(公告)号：US4031399A

公开(公告)日：1977-06-21

申请号：US552653

申请日：1975-02-24

Applicant: Gerald Lee Klein ,  Richard C. Meyer

Inventor： Gerald Lee Klein ,  Richard C. Meyer

IPC: G01J1/04 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01N2201/0806

Abstract: A fluorometer for analyzing a sample by detecting light induced radiation emitted from the sample including apparatus for generating a narrow slit of light in the plane of the sample and transfer apparatus including a light shield having an acutely angled port immediately adjacent the sample for collecting radiation emitted by the sample and transmitting same via a light pipe to a remote detector.

Abstract translation: 一种荧光计，用于通过检测从样品发射的光诱导辐射来检测样品，所述装置用于在样品平面中产生窄的狭缝，并且包括具有紧邻样品的锐角端口的光屏蔽，用于收集辐射的辐射 通过样品并经由光管将其传输到远程检测器。

公开(公告)号：EP3159677A4

公开(公告)日：2018-02-21

申请号：EP15809717

申请日：2015-06-16

Applicant: KONICA MINOLTA INC

Inventor： FUJIYO ICHIRO ,  NODA TETSUYA

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/0806

Abstract: A detection device comprises a chip holder, a light source, a light-guide rod, a wavelength separation filter, and an optical sensor. Given the relationship between the angle of incidence and light intensity of fluorescence on a light reception surface of the optical sensor, the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of fluorescence incident on the light reception surface at a peak angle of incidence at which the light intensity is the highest is greater than the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of excitation light incident on the light reception surface at the peak angle of incidence and is higher than the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of fluorescence incident on the light reception surface at an angle of incidence of 0 DEG.

公开(公告)号：EP3273226A1

公开(公告)日：2018-01-24

申请号：EP16764767.6

申请日：2016-03-08

Applicant: Konica Minolta, Inc.

Inventor： NODA, Tetsuya ,  NAGAI, Fumio ,  YAMAUCHI, Nobuhiro ,  KYOGOKU, Yuichi

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01N21/553 ,  G01N21/64 ,  G01N21/6428 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/0638 ,  G01N2201/0806

Abstract: This detection device has a holder, light irradiation unit, angle adjustment unit, light receiving sensor, light receiving optical system, optical filter, and a control unit. The light receiving optical system guides light from a detection chip to the light receiving sensor. The optical filter is disposed in the light receiving optical system, blocks a part of plasmon scattered light, and passes, out of the light emitted from the detection chip, a part of the plasmon scattered light, and fluorescence emitted from a fluorescent material. The light receiving sensor detects the fluorescent light, and the part of the plasmon scattered light, which have been emitted from the detection chip and passed the optical filter. On the basis of the detection results of the plasmon scattered light, the control unit controls the angle adjustment unit, and adjusts the incident angle of the excitation light to a predetermined incident angle.

Abstract translation: 该检测装置具有支架，光照射单元，角度调整单元，光接收传感器，光接收光学系统，滤光器和控制单元。 光接收光学系统将来自检测芯片的光引导至光接收传感器。 滤光器设置在光接收光学系统中，阻挡等离子体激元散射光的一部分，并且使从检测芯片发射的光中的部分等离子体激元散射光和从荧光材料发出的荧光通过。 光接收传感器检测从检测芯片发出并通过光学滤波器的荧光和部分等离子体激元散射光。 基于等离子体激元散射光的检测结果，控制单元控制角度调节单元，并且将激发光的入射角调节为预定入射角。

公开(公告)号：EP3230719A1

公开(公告)日：2017-10-18

申请号：EP15868139.5

申请日：2015-12-08

Applicant: Molecular Devices LLC

Inventor： ATZLER, Josef, J. ,  KATZLINGER, Michael ,  KRONBERGER, Georg ,  SCHINWALD, Bernhard

IPC: G01N21/64 ,  G01N21/01 ,  G01N1/14 ,  G01V3/08

CPC classification number: G01N21/76 ,  G01J3/02 ,  G01N21/15 ,  G01N21/253 ,  G01N21/763 ,  G01N27/223 ,  G01N35/028 ,  G01N2021/015 ,  G01N2021/155 ,  G01N2035/1025 ,  G01N2201/0225 ,  G01N2201/0245 ,  G01N2201/0446 ,  G01N2201/0806

Abstract: In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample. The assembly may include one or more needles that communicate with one or more reservoirs supplying reagent or other liquids. The assembly may include a light guide for communicating with the detector. A cartridge may be provided in which the assembly, one or more reservoirs, and one or more pumps are disposed. The cartridge and/or the apparatus may be configured for enabling rinsing or priming to be done outside the apparatus. The cartridge and/or the apparatus may include one or more types of sensors configured for detecting, for example, the presence of liquid or bubbles in one or more locations of the apparatus and/or the cartridge.

Abstract translation: 在样品分析装置中，注射器组件将试剂注入到样品上，并且来自样品的发光被传送到检测器。 该组件可以朝向和远离样品移动。 该组件可以包括与供应试剂或其他液体的一个或多个储存器连通的一个或多个针。 该组件可以包括用于与检测器通信的光导。 可以提供盒，其中设置有组件，一个或多个储存器以及一个或多个泵。 盒和/或装置可以被构造成能够在装置外部进行冲洗或灌注。 盒和/或装置可以包括一种或多种类型的传感器，其被配置用于检测例如装置和/或盒的一个或多个位置中是否存在液体或气泡。