公开(公告)号：US20150085296A1

公开(公告)日：2015-03-26

申请号：US14559312

申请日：2014-12-03

Applicant: OLYMPUS CORPORATION

Inventor： Hisashi ODE

IPC: G01N21/17 ,  G01B21/02 ,  G01B9/02

CPC classification number: G01N21/1702 ,  G01B9/02007 ,  G01B9/02091 ,  G01B21/02 ,  G01N29/0672 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2021/1706 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/125 ,  G02B21/002

Abstract: Provided is a photoacoustic microscope, including: an objective lens configured to collect excitation light into a specimen, the excitation light in a wavelength range that is absorbed by an object to be observed; a detection light optical system configured to (i) form an image of a point light source of detection light in a middle portion of a pupil of the objective lens, the detection light having a wavelength that is different from the wavelength range of the excitation light, and (ii) emit the detection light onto the specimen by means of the objective lens; an optical scanning unit configured to deflect the excitation light and the detection light that enter the objective lens, for scanning the specimen; and a light detection unit configured to detect reflected light of the detection light that is reflected by the specimen.

Abstract translation: 本发明提供一种光声显微镜，包括：被配置为将激发光收集到样本中的物镜，所述激发光在被观察对象吸收的波长范围内; 检测光光学系统，被配置为：（i）在所述物镜的光瞳的中间部分形成检测光的点光源的图像，所述检测光的波长与所述激发光的波长范围不同 ，和（ii）通过物镜将检测光发射到样品上; 光学扫描单元，被配置为偏转激发光和进入物镜的检测光，用于扫描样本; 以及光检测单元，被配置为检测由所述检体反射的检测光的反射光。

公开(公告)号：US08978297B2

公开(公告)日：2015-03-17

申请号：US13099964

申请日：2011-05-03

Applicant: Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

Inventor： Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

IPC: A01B79/00 ,  A01B79/02 ,  A01C1/00 ,  A01G1/00 ,  A01H3/00 ,  A01G7/00 ,  G01N1/40 ,  G01N15/14 ,  G06Q99/00 ,  G01N33/00

CPC classification number: G01N21/17 ,  A01G7/00 ,  G01N1/4077 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1463 ,  G01N33/0098 ,  G01N2021/1765 ,  G01N2201/02 ,  G01N2201/125 ,  G06K9/00134 ,  G06Q99/00

Abstract: An apparatus and method of quantitatively obtaining a measurement of pollen of a plant. One method of counting comprises imaging the sample with the pollen well-distributed in the focal plane of the imager. Image evaluation software can identify and count objects in the image that are consistent with pollen. Total pollen count for the plant can be derived from the count of pollen of the sample, proportionality of the sample volume to the starting volume, and proportionality of area of sample imaged to total area of sample. Pollen quantification can be used for research or commercial production decisions relative to the plant or its seed.

公开(公告)号：US20150021478A1

公开(公告)日：2015-01-22

申请号：US14070848

申请日：2013-11-04

Applicant: DAESUNG TECH CO., LTD.

Inventor： Ho Yun Lee ,  Young Su Do ,  No Jin Park

IPC: G01N33/02 ,  G06F17/18 ,  G01N25/00 ,  G01N21/35 ,  G01N21/27

CPC classification number: G01N33/025 ,  G01N21/255 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/474 ,  G01N2021/4759 ,  G01N2201/0221 ,  G01N2201/0646 ,  G01N2201/125 ,  G01N2201/126 ,  G01N2201/129

Abstract: A non-destructive sugar content measuring apparatus is provided and includes a measuring sensor portion for including a spectral sensor which receives a near infrared ray from the light which is reflected by the flesh FB of the fruit F of which the sugar content is measured, an LED light source which has LEDs circularly arranged, an optical sensor which receives light reflected by a flesh of a fruit F, and a temperature sensor; a casing including a measuring sensor portion and has a panel portion which has a digital display for displaying a brix value as a digital value and operational switches, the panel portion and the operational switches being mounted on a front face thereof; a main circuit board PB for including a Central Processing Unit (CPU) which is embedded in the casing and processes electric signals from the light sensor and performs a calculation and determination

Abstract translation: 提供了一种无损糖含量测量装置，其包括测量传感器部分，该测量传感器部分包括光谱传感器，该光谱传感器从被测量糖含量的果实F的肉FB反射的光中接收近红外线， 具有圆形布置的LED的LED光源，接收由果实F的肉体反射的光的光学传感器和温度传感器; 壳体，包括测量传感器部分，并且具有面板部分，其具有用于显示白利糖度值作为数字值的数字显示器和操作开关，所述面板部分和操作开关安装在其正面上; 主电路板PB，其包括嵌入在壳体中的中央处理单元（CPU），并处理来自光传感器的电信号，并执行计算和确定

公开(公告)号：US20130202187A1

公开(公告)日：2013-08-08

申请号：US13368306

申请日：2012-02-07

Applicant: Zvi Goren ,  Nir Ben-David Dodzin

Inventor： Zvi Goren ,  Nir Ben-David Dodzin

IPC: G06K9/32

CPC classification number: G06T7/0008 ,  G01B11/14 ,  G01N21/9501 ,  G01N2201/10 ,  G01N2201/125 ,  G01N2201/127 ,  G06T7/32 ,  G06T2207/30148

Abstract: A system for location based wafer analysis, the system comprising: (i) a first input interface; (ii) a second input interface; (iii) a correlator; and (iv) a processor, configured to generate inspection results for the inspected wafer, with the help of at least one frame run-time displacement.

公开(公告)号：US07321791B2

公开(公告)日：2008-01-22

申请号：US10669101

申请日：2003-09-23

Applicant: Richard Levenson ,  Paul J. Cronin

Inventor： Richard Levenson ,  Paul J. Cronin

IPC: A61B6/00

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract translation: 提供了设备和方法，用于使用光谱成像提供高度敏感的检测来生物样本中深层组织中的结构成像。 通过获取提供具有不同光谱加权的样本的多个图像的数据和随后的光谱分析，来自目标化合物的光发射与样品中的自发荧光分离。 随着自发荧光降低或消除，获得目标化合物的改进的测量。

公开(公告)号：US20070016082A1

公开(公告)日：2007-01-18

申请号：US11522745

申请日：2006-09-18

Applicant: Richard Levenson ,  Paul Cronin

Inventor： Richard Levenson ,  Paul Cronin

IPC: A61B6/00

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract translation: 提供了设备和方法，用于使用光谱成像提供高度敏感的检测来生物样本中深层组织中的结构成像。 通过获取提供具有不同光谱加权的样本的多个图像的数据和随后的光谱分析，来自目标化合物的光发射与样品中的自发荧光分离。 随着自发荧光降低或消除，获得目标化合物的改进的测量。

公开(公告)号：US20050065440A1

公开(公告)日：2005-03-24

申请号：US10669101

申请日：2003-09-23

Applicant: Richard Levenson

Inventor： Richard Levenson

IPC: A61B5/00 ,  G01J3/32 ,  G01J3/44 ,  G01J3/453 ,  A61B6/00

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract translation: 提供了设备和方法，用于使用光谱成像提供高度敏感的检测来生物样本中深层组织中的结构成像。 通过获取提供具有不同光谱加权的样本的多个图像的数据和随后的光谱分析，来自目标化合物的光发射与样品中的自发荧光分离。 随着自发荧光降低或消除，获得目标化合物的改进的测量。

公开(公告)号：WO2015074004A1

公开(公告)日：2015-05-21

申请号：PCT/US2014/066013

申请日：2014-11-17

Applicant: QUANTUM-SI INCORPORATED

Inventor： ROTHBERG, Jonathan, M. ,  KABIRI, Ali ,  SICKLER, Jason, W. ,  GYARFAS, Brett, J. ,  LACKEY, Jeremy ,  SCHMID, Gerard ,  CIPRIANY, Benjamin ,  JEWELL, Jack ,  WEST, Lawrence ,  FERRIGNO, Michael ,  GLENN, Paul, E. ,  BELLOFIORE, Anthony

IPC: C12Q1/68 ,  G01N21/64 ,  G01N21/77

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/168 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/7743 ,  G01N21/7746 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/125 ,  Y10T29/49016 ,  C12Q2525/101

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.

Abstract translation: 用于分析单分子和进行核酸测序的装置和方法。 集成装置包括多个像素，其中样品阱被配置为接收样品，当被激发时，样品阱发射辐射; 用于在特定方向上引导发射辐射的至少一个元件; 以及发射辐射从样品阱向传感器行进的光路。 该装置还包括与集成装置接口的仪器。 每个传感器可以检测来自相应样品阱中的样品的发射辐射。 该仪器包括用于激发每个样品孔中的样品的激发光源。

公开(公告)号：WO2015069751A1

公开(公告)日：2015-05-14

申请号：PCT/US2014/064103

申请日：2014-11-05

Applicant: KLA-TENCOR CORPORATION

Inventor： PARK, Allen ,  MACNAUGHTON, Craig ,  CHANG, Ellis

IPC: H01L21/66

CPC classification number: G01N21/93 ,  G01B11/06 ,  G01B11/0675 ,  G01B2210/56 ,  G01N21/9501 ,  G01N21/956 ,  G01N2201/061 ,  G01N2201/105 ,  G01N2201/11 ,  G01N2201/125 ,  G03F7/705 ,  G03F7/70616

Abstract: Methods and systems for determining one or more parameters of a wafer inspection process are provided. One method includes acquiring metrology data for a wafer generated by a wafer metrology system. The method also includes determining one or more parameters of a wafer inspection process for the wafer or another wafer based on the metrology data.

Abstract translation: 提供了用于确定晶片检查过程的一个或多个参数的方法和系统。 一种方法包括获取由晶片计量系统产生的晶片的度量数据。 该方法还包括基于测量数据确定晶片或另一晶片的晶片检查过程的一个或多个参数。

公开(公告)号：WO2015030562A1

公开(公告)日：2015-03-05

申请号：PCT/KR2014/008183

申请日：2014-09-02

Applicant: 한국광기술원

Inventor： 이병일 ,  신인희 ,  박재석 ,  엄주범 ,  박형주 ,  김석기

IPC: G01N21/64

CPC classification number: H04N5/332 ,  A61B5/0033 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/7225 ,  A61B5/7445 ,  G01N21/6456 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/125 ,  H04N5/23293 ,  H04N9/3179

Abstract: 본 발명은 광대역 영상 획득투사 장치에 관한 것으로서, 프로브 하우징 상에 피사체에 가시광 영상 획득을 위한 백색광을 출사하는 백색광원부와, 비가시광 형광영상 획득을 위한 형광여기용 광을 출사하는 형광여기광원부와, 피사체에 대한 비가시광 형광영상신호를 수신하는 영상획득부 및 피사체에 영상을 투사하기 위한 영상투사부가 마련된 프로브 유니트와, 영상 획득부로부터 수신된 영상을 처리하는 영상처리부를 포함한다. 이러한 광대역 영상 획득투사 장치에 의하면, 가시광 영상 및 비가시광 형광영상을 동시에 획득하여 표시할 수 있고, 획득된 형광영상은 형광신호가 발현되는 위치에 투사됨으로써 형광신호의 발생 위치와 형태를 시각적으로 제공할 수 있는 장점을 제공한다.

Abstract translation: 本发明涉及一种宽带图像获取投影设备，包括：白光源单元，用于发射白光以获取探测器壳体上的被摄体的可见光图像; 用于发射用于荧光激发的光以获得不可见光荧光图像的荧光激发光源单元; 具有图像获取单元和布置在其中的图像投影单元的探针单元，所述图像获取单元接收对象的不可见光荧光图像信号，所述图像投影单元用于在被摄体上投影图像; 以及图像处理单元，用于处理从图像获取单元接收的图像。 本发明的优点在于，宽带图像获取投影装置可以同时获取和显示可见光图像和不可见光荧光图像，并且可以将所获取的荧光图像投影到荧光信号表达的位置，从而可视地提供生成 位置和形状的荧光信号。