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公开(公告)号：US20240032829A1
公开(公告)日：2024-02-01
申请号：US18274545
申请日：2022-02-25
Applicant: DATAMED S.R.L.
Inventor： Giampiero Porro , Alessandro Torinesi , Roberto Pozzi , Giovanna Quarto , Luca Bolzoni
IPC: A61B5/1455 , G01N21/64 , G01N21/85 , A61M1/36
CPC classification number: A61B5/14557 , G01N21/6408 , G01N21/85 , A61M1/3609 , G01N2021/6482 , G01N2201/1296 , A61M2230/205
Abstract: The present invention refers to a device (1) and a method of measuring a parameter of blood, preferably correlated to the presence or concentration of oxygen in blood. The invention provides to: excite a photosensitive element (18′) in contact with blood by excitation pulses, detect light responses of the photosensitive element corresponding to the excitation pulses, and analyze the plurality of luminescence decay curves at least two time windows (t1-tN). Moreover, the invention provides to: detect one or more light answer analog information regarding the luminescence curve decay at each time window, convert the analog information into digital data, process the digital data and the actual temperature value of blood by taking into account a plurality of data of previous measures of the parameter of blood performed during a previous training, and determine, as a result of the processing step, at least one value of said parameter of blood.
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92.发明申请公开(公告)号：US20190063215A1
公开(公告)日：2019-02-28
申请号：US15535693
申请日：2016-09-22
Applicant: HALLIBURTON ENERGY SERVICES, INC
Inventor： Bin DAI , Christopher Michael JONES , Dingding CHEN
IPC: E21B49/08 , G01N21/33 , G01N21/359 , G01N21/3577 , G01N21/31 , E21B44/00 , E21B47/12 , E21B47/00
CPC classification number: E21B49/08 , E21B44/00 , E21B47/00 , E21B47/102 , E21B47/12 , G01N21/31 , G01N21/314 , G01N21/33 , G01N21/3577 , G01N21/359 , G01N2021/3155 , G01N2021/3174 , G01N2201/1293 , G01N2201/1296 , G06N3/0454 , G06N3/08 , H03M7/3062
Abstract: A system includes an optical computing device having an optical multiplexer that receives a sample light generated by an optical interaction between a sample and an illumination light is provided. The system includes sensing elements that optically interact with the sample light to generate modified lights, and a detector that measures a property of the modified lights separately. Linear and nonlinear models for processing data collected with the above system to form high-resolution spectra are also provided. Methods for designing optimal optical multiplexers for optimal reconstruction of high-resolution spectra are also provided.
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公开(公告)号：US20170140299A1
公开(公告)日：2017-05-18
申请号：US15322693
申请日：2015-06-30
Applicant: CANON KABUSHIKI KAISHA
Inventor： Koichi TANJI
CPC classification number: G06N20/00 , G01N21/274 , G01N21/31 , G01N21/65 , G01N2201/06113 , G01N2201/1293 , G01N2201/1296
Abstract: A data processing apparatus that processes a spectral data item which stores, for each of a plurality of spectral components, an intensity value, includes a spectral component selecting unit and a classifier generating unit. The spectral component selecting unit is configured to select, based on a Mahalanobis distance between groups each composed of a plurality of spectral data items or a spectral shape difference between groups each composed of a plurality of spectral data items, a plurality of machine-learning spectral components from among the plurality of spectral components of the plurality of spectral data items. The classifier generating unit is configured to perform machine learning by using the plurality of machine-learning spectral components selected by the spectral component selecting unit and generate a classifier that classifies a spectral data item.
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94.发明授权公开(公告)号：US09365883B2
公开(公告)日：2016-06-14
申请号：US14367060
申请日：2012-12-19
Applicant: OPTICUL DIAGNOSTICS LTD. , OPTICUL DIAGNOSTICS Inc.
Inventor： Gallya Gannot , Dror Lederman , Hassan Moinuddin , Israel Gannot
IPC: G01N21/00 , C12Q1/04 , G01N21/65 , G01N21/3577 , G01N21/25 , C12M1/34 , G01N21/39 , G01N21/64 , G01N21/35 , G01N21/17 , G06F19/10
CPC classification number: C12Q1/04 , C12M41/36 , G01N21/255 , G01N21/3577 , G01N21/39 , G01N21/64 , G01N21/65 , G01N2021/1742 , G01N2021/1744 , G01N2021/3595 , G01N2021/6417 , G01N2201/06113 , G01N2201/129 , G01N2201/1296 , G06F19/10
Abstract: A spectroscopic method for spectroscopic detection and identification of bacteria in culture is disclosed. The method incorporates construction of at least one data set, which may be a spectrum, interference pattern, or scattering pattern, from a cultured sample suspected of containing said bacteria. The data set is corrected for the presence of water in the sample, spectral features are extracted using a principal components analysis, and the features are classified using a learning algorithm. In some embodiments of the invention, for example, to differentiate MRSA from MSSA, a multimodal analysis is performed in which identification of the bacteria is made based on a spectrum of the sample, an interference pattern used to determine cell wall thickness, and a scattering pattern used to determine cell wall roughness. An apparatus for performing the method is also disclosed, one embodiment of which incorporates a multiple sample analyzer.
Abstract translation: 公开了用于光谱检测和鉴定培养细菌的光谱方法。 该方法包括来自怀疑含有所述细菌的培养样品的至少一个数据集的构建，其可以是光谱，干涉图案或散射图案。 对样品中水的存在进行数据集的校正，使用主成分分析提取光谱特征，并使用学习算法对特征进行分类。 在本发明的一些实施方案中，例如为了区分MRSA和MSSA，进行多模态分析，其中基于样品的光谱，用于确定细胞壁厚度的干涉图案和散射来确定细菌的鉴定 用于确定细胞壁粗糙度的图案。 还公开了一种用于执行该方法的装置，其一个实施例包括多个样本分析器。
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公开(公告)号：US20150276477A1
公开(公告)日：2015-10-01
申请号：US14737622
申请日：2015-06-12
Applicant: PD-LD, Inc.
Inventor： BORIS LEONIDOVICH VOLODIN , Vladimir Sinisa Ban
CPC classification number: G01J3/0256 , G01J3/00 , G01J3/10 , G01J3/1895 , G01J3/44 , G01J3/4412 , G01J2003/104 , G01N21/65 , G01N21/658 , G01N2021/1793 , G01N2201/0221 , G01N2201/129 , G01N2201/1296 , G02B6/29319 , H01S5/005 , H01S5/32 , H01S5/4012 , H01S5/4087
Abstract: Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. A switch may provide switching between the first and second laser sources. An ensemble of laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.
Abstract translation: 用于执行拉曼光谱的装置可以包括具有第一发射波长的第一激光源和具有第二发射波长的第二激光源。 第一和第二发射波长之间的间隔可以对应于感兴趣物质的拉曼带的宽度。 开关可以提供第一和第二激光源之间的切换。 可以提供激光发射器的组合。 布拉格光栅元件可以接收来自集合体的激光。 光学系统可以将来自布拉格光栅元件的光引导到光纤中。 通过光纤的组合光束可以包含来自每个发射器的光。
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Patent Agency Ranking
公开(公告)号：US09068883B2
公开(公告)日：2015-06-30
申请号：US14149321
申请日：2014-01-07
Applicant: PD-LD, Inc.
Inventor： Boris Leonidovich Volodin , Vladimir Sinisa Ban
CPC classification number: G01J3/0256 , G01J3/00 , G01J3/10 , G01J3/1895 , G01J3/44 , G01J3/4412 , G01J2003/104 , G01N21/65 , G01N21/658 , G01N2021/1793 , G01N2201/0221 , G01N2201/129 , G01N2201/1296 , G02B6/29319 , H01S5/005 , H01S5/32 , H01S5/4012 , H01S5/4087
Abstract: Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. A switch may provide switching between the first and second laser sources. An ensemble of individually addressable laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.
Abstract translation: 用于执行拉曼光谱的装置可以包括具有第一发射波长的第一激光源和具有第二发射波长的第二激光源。 第一和第二发射波长之间的间隔可以对应于感兴趣物质的拉曼带的宽度。 开关可以提供第一和第二激光源之间的切换。 可以提供可单独寻址的激光发射器的组合。 布拉格光栅元件可以接收来自集合体的激光。 光学系统可以将来自布拉格光栅元件的光引导到光纤中。 通过光纤的组合光束可以包含来自每个发射器的光。
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公开(公告)号：US09025850B2
公开(公告)日：2015-05-05
申请号：US13067777
申请日：2011-06-24
Applicant: Max Diem , Benjamin Bird , Milos Miljkovic , Stanley H. Remiszewski , Clay M. Thompson
Inventor： Max Diem , Benjamin Bird , Milos Miljkovic , Stanley H. Remiszewski , Clay M. Thompson
IPC: G06K9/00 , G06T7/00 , G01N21/64 , G01N21/65 , G01N21/552 , G01V3/00 , A61B5/00 , G01N21/3581 , G01N21/35
CPC classification number: G01N21/31 , A61B5/0071 , A61B5/0075 , A61B5/415 , A61B5/418 , A61B5/7257 , G01N21/35 , G01N21/3581 , G01N21/552 , G01N21/6456 , G01N21/65 , G01N2021/3595 , G01N2021/6417 , G01N2021/653 , G01N2201/1293 , G01N2201/1296 , G06F19/00 , G06K9/00134 , G06K9/00147 , G06K2009/4657 , G06T7/30 , G06T2207/20101 , G06T2207/30024 , G16H50/20
Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.
Abstract translation: 通过光谱成像分析生物样本以提供医学诊断的方法包括获得生物标本的光谱和视觉图像并登记图像以检测细胞异常，癌前细胞和癌细胞。 该方法消除了标准组织病理学和其他光谱方法固有的诊断的偏倚和不可靠性。 此外，用于校正在细胞和组织的显微取得的红外光谱中经常观察到的混杂光谱贡献的方法包括对光谱数据执行相位校正。 该相位校正方法可用于校正被反射组件污染的各种类型的吸收光谱。
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公开(公告)号：US20130044210A1
公开(公告)日：2013-02-21
申请号：US13379443
申请日：2010-06-27
Applicant: Israel Rozenboim , Eyal Ben Dor
Inventor： Israel Rozenboim , Eyal Ben Dor
CPC classification number: G01N21/31 , G01N21/3563 , G01N33/08 , G01N2021/3155 , G01N2201/1296
Abstract: A hyperspectral method for detecting the present condition of an avian egg is disclosed in which a neural network algorithm is used to compare the spectrum of a test egg against a spectral library. The method can detect fertility with greater than 90% reliability on the day of laying and the gender of the chick with greater than 75% reliability on the 12th day after laying.
Abstract translation: 公开了一种用于检测禽蛋现状的超光谱方法，其中使用神经网络算法来比较测试卵与光谱库的光谱。 该方法可以在放置当天以高达90％的可靠性检测生育能力，并且在放置后第12天可以检测到具有高于75％可靠性的小鸡的性别。
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99.发明授权System and method for analyzing biological samples using Raman molecular imaging 有权使用拉曼分子成像分析生物样品的系统和方法公开(公告)号：US07990533B2
公开(公告)日：2011-08-02
申请号：US12834370
申请日：2010-07-12
Applicant: John Maier , Shona Stewart , Jeffrey Cohen
Inventor： John Maier , Shona Stewart , Jeffrey Cohen
CPC classification number: G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。
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100.发明申请System and Method for Analyzing Biological Samples Using Raman Molecular Imaging 有权使用拉曼分子成像分析生物样品的系统和方法公开(公告)号：US20100280762A1
公开(公告)日：2010-11-04
申请号：US12834370
申请日：2010-07-12
Applicant: John Maier , Shona Stewart , Jeffrey Cohen
Inventor： John Maier , Shona Stewart , Jeffrey Cohen
CPC classification number: G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。
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