公开(公告)号：EP0310191A3

公开(公告)日：1990-12-12

申请号：EP88202116.5

申请日：1988-09-28

Applicant: UNION CARBIDE CORPORATION

Inventor： Nelson, James Russell

IPC: C07C201/00 ,  C07C203/00 ,  B01D3/00

CPC classification number: B01D3/009 ,  C07C201/04 ,  Y02P20/127 ,  C07C203/00

Abstract: A process and reaction vessel for producing alkyl nitrite is disclosed, the process comprising (a) contacting nitric oxide¸ lower alcohol and oxygen in a reaction zone such that alkyl nitrite is formed, said reaction zone comprising a reactor section and a rectification section, (b) supplying a liquid scrubbing agent to an upper portion of the rectification section, (c) withdrawing a gaseous alkyl nitrite product stream from the upper portion of the rectification section, and (d) withdrawing a liquid stream from a lower portion of the reactor section. The reactor section provides intimate vapor-liquid contact sufficient to enhance the conver­sion of nitric oxide to alkyl nitrite and the rectification section provides sufficient vapor residence time to enhance conversion of oxygen, as well as sufficient rectification capabilities to reduce the amounts of water and nitric acid in the gaseous alkyl nitrite product stream.

公开(公告)号：EP0212823B1

公开(公告)日：1990-02-07

申请号：EP86305281.7

申请日：1986-07-09

Applicant: MITSUI TOATSU CHEMICALS, Inc.

Inventor： Yamaguchi, Keizaburo ,  Sugimoto, Kenichi ,  Tanabe, Yoshimitsu ,  Nagata, Teruyuki ,  Yamaguchi, Akihiro

IPC: C07C315/06 ,  C07C201/00 ,  C07C205/00

CPC classification number: C07C201/16 ,  C07C315/04 ,  C07C315/06 ,  C07C205/45 ,  C07C317/14

公开(公告)号：EP0310191A2

公开(公告)日：1989-04-05

申请号：EP88202116.5

申请日：1988-09-28

Applicant: UNION CARBIDE CORPORATION

Inventor： Nelson, James Russell

IPC: C07C201/00 ,  C07C203/00 ,  B01D3/00

CPC classification number: B01D3/009 ,  C07C201/04 ,  Y02P20/127 ,  C07C203/00

Abstract: A process and reaction vessel for producing alkyl nitrite is disclosed, the process comprising (a) contacting nitric oxide¸ lower alcohol and oxygen in a reaction zone such that alkyl nitrite is formed, said reaction zone comprising a reactor section and a rectification section, (b) supplying a liquid scrubbing agent to an upper portion of the rectification section, (c) withdrawing a gaseous alkyl nitrite product stream from the upper portion of the rectification section, and (d) withdrawing a liquid stream from a lower portion of the reactor section. The reactor section provides intimate vapor-liquid contact sufficient to enhance the conver­sion of nitric oxide to alkyl nitrite and the rectification section provides sufficient vapor residence time to enhance conversion of oxygen, as well as sufficient rectification capabilities to reduce the amounts of water and nitric acid in the gaseous alkyl nitrite product stream.

Abstract translation: 公开了一种用于生产亚硝酸烷基酯的方法和反应容器，该方法包括（a）在反应区中使一氧化氮和己二醇与低级醇与氧接触，从而形成亚硝酸烷基酯，所述反应区包括反应器部分和精馏段（ b）将液体洗涤剂供应到精馏段的上部，（c）从精馏段的上部排出气态烷基亚硝酸盐产物流，和（d）从反应器的下部排出液体物流 部分。 反应器部分提供充分的气液接触，足以增强一氧化氮向亚硝酸烷基酯的转化，并且精馏段提供足够的蒸气停留时间，以提高氧气的转化率，以及足够的整流能力以减少水和硝酸的量 在气态烷基亚硝酸盐产物流中。

公开(公告)号：WO2023025971A2

公开(公告)日：2023-03-02

申请号：PCT/EP2022/085782

申请日：2022-12-14

Applicant: MERCK PATENT GMBH

Inventor： MUJICA-FERNAUD, Teresa ,  MONTENEGRO, Elvira ,  WIRGES, Christian

IPC: C07C201/00 ,  C09K11/00

Abstract: Die vorliegende Anmeldung betrifft Verbindungen einer Formel (I) und (II), Verfahren zur Herstellung solcher Verbindungen, sowie elektronische Vorrichtungen enthaltend eine oder mehrere solcher Verbindungen, und die Verwendung solcher Verbindungen in elektronischen Vorrichtungen.

公开(公告)号：WO2021178259A1

公开(公告)日：2021-09-10

申请号：PCT/US2021/020175

申请日：2021-03-01

Applicant: TAN, Wen

Inventor： TAN, Wen

IPC: C07C45/63 ,  C07C49/84 ,  C07B2200/13 ,  C07C201/00

Abstract: The present invention relates to a novel crystalline form of (R)-terbutaline hydrochloride salt, its process and its therapeutically uses.

公开(公告)号：WO2019011709A1

公开(公告)日：2019-01-17

申请号：PCT/EP2018/067867

申请日：2018-07-03

Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.

Inventor： VAN DAM, Hendrik ,  LAKE, Karl Fredrik ,  KANTZER, Eike Nicolas ,  TEN KATE, Antoon Jacob Berend ,  EDVINSSON, Rolf Krister ,  RAAIJMAKERS, Michiel Jozef Thomas ,  VENEMAN, Rens ,  EHLERS, Ina ,  ADRIAN MEREDITH, Jenny Valborg Therese ,  JOVIC, Slavisa

IPC: C07D295/125 ,  C07C209/16 ,  C07C201/00

Abstract: The invention pertains to a process for manufacturing a mixture of straight-chain higher ethyleneamines and non-straight-chain higher ethyleneamines selected from branched higher ethyleneamines and cyclic higher ethyleneamines, or the urea derivatives thereof, comprising the step of reacting amine-functional compound with ethanolamine-functional compound in the presence of a carbon oxide delivering agent, wherein a) amine-functional compound comprising a combination of straight-chain amine- functional compound and non-straight-chain amine-functional compound is reacted with straight-chain ethanolamine-functional compound, or b) straight-chain amine-functional compound is reacted with ethanolamine-functional compound comprising a combination of straight-chain ethanolamine-functional compound and non-straight-chain ethanolamine-functional compound, or c) amine-functional compound comprising a combinationof straight-chain amine-functional compound and non-straight-chain amine-functional compound is reacted with ethanolamine-functional compound comprising a combination of straight-chain ethanolamine-functional compound and non-straight-chain ethanolamine-functional compound. It has been found that the process according to the invention makes it possible to prepare tailor-made mixtures of straight-chain and non-straight-chain higher ethyleneamines, or urea derivatives thereof.

公开(公告)号：WO2013050301A1

公开(公告)日：2013-04-11

申请号：PCT/EP2012/069171

申请日：2012-09-28

Applicant: SYNGENTA PARTICIPATIONS AG ,  SMEJKAL, Tomas ,  SMITS, Helmars ,  WENDEBORN, Sebastian, Volker ,  BERTHON, Guillaume ,  CASSAYRE, Jérôme, Yves ,  EL QACEMI, Myriem

Inventor： SMEJKAL, Tomas ,  SMITS, Helmars ,  WENDEBORN, Sebastian, Volker ,  BERTHON, Guillaume ,  CASSAYRE, Jérôme, Yves ,  EL QACEMI, Myriem

IPC: C07D207/08 ,  C07D207/40 ,  C07D307/46 ,  C07D409/12 ,  C07D207/333 ,  C07D207/267 ,  A01N43/36 ,  C07C201/00 ,  C07C201/12 ,  C07C205/45 ,  C07C253/10 ,  C07C255/17

CPC classification number: C07D453/04 ,  C07C253/10 ,  C07C253/30 ,  C07C255/40 ,  C07C255/41 ,  C07D207/08 ,  C07D207/12 ,  C07D207/267 ,  C07D207/325 ,  C07D207/333 ,  C07D207/40 ,  C07D307/46 ,  C07D409/12

Abstract: The present invention relates to processes for the enantio-selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds, as well as to intermedates in the processes. The processes include those comprising (a-i) reacting a compound of formula (Ia), formula (Ia), wherein P is alkyl, aryl or heteroaryl, each optionally substituted, wherein the heteroaryl is connected at P via a ring carbon atom; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is aryl or heteroaryl, each optionally substituted; with a source of cyanide in the presence a chiral catalyst to give a compound of formula IIa, formula (IIa), wherein P, R 1 and R 2 are as defined for the compound of formula (Ia); and (a-ii) oxidising the compound of formula IIa with a peroxy acid, or peroxide in the presence of an acid to give a compound of formula (VI), formula (VI), wherein R 1 and R 2 are as defined for the compound of formula (Ia).

Abstract translation: 本发明涉及用于制备杀虫活性化合物的螺旋体衍生物的对映选择性制备方法，以及在该方法中的介入。 所述方法包括（a-i）使式（Ia），式（Ia）化合物（其中P是烷基，芳基或杂芳基）各自任选取代的化合物，其中杂芳基通过环碳原子在P连接; R1是氯二氟甲基或三氟甲基; R 2是芳基或杂芳基，各自任选被取代; 在存在手性催化剂的情况下产生氰化物源，得到式IIa化合物，式（IIa），其中P，R 1和R 2如对于式（Ia）化合物所定义; 和（a-ii）在酸存在下用过氧酸或过氧化物氧化式IIa化合物，得到式（VI），式（VI）的化合物，其中R 1和R 2如化合物 的式（Ia）。

公开(公告)号：WO2006036768A3

公开(公告)日：2006-09-28

申请号：PCT/US2005034091

申请日：2005-09-22

Applicant: TEES THE FLORIDA INTERNAT UNIV ,  BECKER DAVID ,  LEY JAMES JOSEPH

Inventor： BECKER DAVID ,  LEY JAMES JOSEPH

IPC: A61K31/435 ,  A61K31/15 ,  A61K31/166 ,  A61K31/277 ,  C07C201/00 ,  C07C205/00 ,  C07C207/00

CPC classification number: C07D213/20 ,  C07C291/02 ,  C07C309/46 ,  C07C323/45 ,  C07C2601/14 ,  C07D207/46 ,  C07D339/08

Abstract: The present invention provides azulenyl nitrones, such as those having the following general formula: (I) compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine-mediated conditions.

Abstract translation: 本发明提供了az基硝酮，例如具有以下通式的那些：（I）包含其的组合物及其用于治疗或预防氧化，缺血，缺血/再灌注相关和趋化因子介导的病症的方法。

公开(公告)号：WO2004026808A1

公开(公告)日：2004-04-01

申请号：PCT/SE2003/001465

申请日：2003-09-18

Applicant: ASTRAZENECA UK LIMITED ,  ASTRAZENECA AB ,  ANDERSSON, Johan ,  BELLI, Aldo ,  CANNATA, Vincenzo ,  HEDBERG, Martin ,  PALMGREN, Andreas ,  SCHULDEI, Sigrid ,  STRÖM, Marika ,  VILLA, Marco

Inventor： ANDERSSON, Johan ,  BELLI, Aldo ,  CANNATA, Vincenzo ,  HEDBERG, Martin ,  PALMGREN, Andreas ,  SCHULDEI, Sigrid ,  STRÖM, Marika ,  VILLA, Marco

IPC: C07C201/00

CPC classification number: C07C303/28 ,  A61K31/216 ,  C07C67/08 ,  C07C201/02 ,  C07C203/04 ,  C07C227/16 ,  C07C227/20 ,  C07C229/42 ,  C07C309/66 ,  C07C69/738

Abstract: The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donating compounds. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active NO-donating compounds.The invention further relates to a substantially crystalline form of NO-donating NSAIDs, especially 2-[2-(nitrooxy)ethoxy]ethyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate, the preparation thereof and to pharmaceutical formulations containing said crystalline form and to the use of said crystalline form in the preparation of a medicament.

Abstract translation: 本发明涉及使用磺化中间体制备供氧化合物的新方法。 本发明涉及其中制备的适用于大量制备供体化合物的新中间体。 本发明还涉及新的中间体用于制备药物活性供体化合物的用途。本发明还涉及供体NSAID的基本上结晶形式，特别是2- [2-（硝基氧基）乙氧基]乙基{ 2 - [（2,6-二氯苯基）氨基]苯基}乙酸酯，其制备方法和含有所述结晶形式的药物制剂以及使用所述结晶形式制备药物。

公开(公告)号：WO8800227A3

公开(公告)日：1988-08-11

申请号：PCT/EP8700317

申请日：1987-06-19

Applicant: MERCK PATENT GMBH ,  DORSCH DIETER ,  EIDENSCHINK RUDOLF ,  WAECHTLER ANDREAS ,  RIEGER BERNHARD ,  FINKELMANN HEINO

Inventor： DORSCH DIETER ,  EIDENSCHINK RUDOLF ,  WAECHTLER ANDREAS ,  RIEGER BERNHARD ,  FINKELMANN HEINO

IPC: C07C67/00 ,  C07C201/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/45 ,  C07C327/22 ,  C07C331/26 ,  C08F20/02 ,  C08F20/10 ,  C08F291/00 ,  C08G85/00 ,  C09K19/30 ,  C09K19/34 ,  C09K19/38 ,  G02F1/13

CPC classification number: C09K19/3098 ,  C07C255/00 ,  C09K19/3001 ,  C09K19/3402 ,  C09K19/3441 ,  C09K19/3483 ,  C09K19/3491 ,  C09K2019/0448 ,  C09K2019/3422

Abstract: Polymerizable liquid crystal materials and polymer materials displaying liquid crystal phases, which have mesogenous groups linked directly or via a spacer, which groups contain at least one transversely polarizing structural element of formulas I to X of claim 1.