公开(公告)号：US12201758B2

公开(公告)日：2025-01-21

申请号：US18116092

申请日：2023-03-01

Applicant: X-Cor Therapeutics Inc.

Inventor： Steven Paul Keller ,  Brian Yale Chang ,  Jayon Wang

IPC: A61M1/16 ,  A61M1/36 ,  B01D19/00 ,  B01D61/24 ,  B01D63/02

Abstract: Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

公开(公告)号：US20030059852A1

公开(公告)日：2003-03-27

申请号：US09801089

申请日：2001-03-08

Applicant: COR Therapeutics, Inc.

Inventor： David R. Phillips ,  Deborah Ann Law ,  Lisa Nannizzi Alaimo

IPC: G01N033/53 ,  A61K038/16 ,  C07K014/00

CPC classification number: C07K14/70546

Abstract: The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the null-subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block integrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.

Abstract translation: 本发明公开了信号蛋白结合所需的整联蛋白β亚单位的细胞质酪氨酸残基的磷酸化。 本发明提供鉴定涉及整联蛋白介导的信号传导的信号载体的方法，鉴定阻断整联蛋白介导信号传导的试剂的方法，使用阻断整联蛋白介导的信号传导调节生物和病理过程的试剂的方法，以及阻断整合素介导的信号传导的试剂。

公开(公告)号：US20020137174A1

公开(公告)日：2002-09-26

申请号：US10071223

申请日：2002-02-11

Applicant: COR Therapeutics, Inc.

Inventor： Daniel R. Storm ,  Beth Hacker ,  James E. Tomlinson

IPC: C12N009/22 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C12N9/88

Abstract: A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described

Abstract translation: 描述了编码人腺苷酸环化酶的DNA序列。 还描述了腺苷酸环化酶的氨基酸序列

公开(公告)号：CA2100559C

公开(公告)日：2007-05-22

申请号：CA2100559

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

IPC: A61K39/395 ,  C12N15/18 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  G01N33/74

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular re-gion domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are pro-vided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening or ligand analogues.

公开(公告)号：AR029371A1

公开(公告)日：2003-06-25

申请号：ARP000103246

申请日：2000-06-28

Applicant: COR THERAPEUTICS INC ,  ORTHO MCNEIL PHARM INC

IPC: A61P7/02 ,  C07D209/14 ,  C07D231/56 ,  C07D403/06 ,  A61K31/4045 ,  A61K31/416 ,  C07D401/14 ,  C07D409/14

Abstract: Está dirigida a compuestos de urea-peptoide de indol e indazol, segun formula (1), en donde R1 a R8, m, n, y p tienen los significados dados en la memoria descriptiva, que son utiles como antagonistas del receptor de trombina, para el tratamiento de enfermedades asociadas con trombosis, restenosis, hipertension, insuficiencia cardíaca, arritmia, inflamacion, angina, ataque, ateroesclerosis, condiciones isquémicas, desordenes relacionados con angiogénesis, cáncer, y desordenes neurodegenerativos. Además se describen composiciones farmacéuticas que comprenden los compuestos de urea-peptoide de indazol e indol sustituidos de la presente, y al uso de dichos compuestos es para la manufactura de un medicamento para el tratamiento de condiciones mediadas por el receptor de trombina.

公开(公告)号：DE69803383T2

公开(公告)日：2002-09-26

申请号：DE69803383

申请日：1998-08-11

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH M

IPC: A61K38/00 ,  A61P7/02 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  A61K38/04

公开(公告)号：AU747531B2

公开(公告)日：2002-05-16

申请号：AU6962398

申请日：1998-04-13

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  SCARBOROUGH ROBERT M ,  ZHU BING-YAN

IPC: A61K31/495 ,  A61K31/496 ,  A61K31/551 ,  A61P7/02 ,  A61P43/00 ,  C07D211/26 ,  C07D241/08 ,  C07D243/08 ,  C07D295/15 ,  C07D295/205 ,  C07D401/06 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14 ,  C07K5/062 ,  C07K5/083 ,  C07D295/20

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：NO20021229D0

公开(公告)日：2002-03-12

申请号：NO20021229

申请日：2002-03-12

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  ZHANG PENGLIE ,  HUANG WENRONG ,  SONG YONGHONG ,  WANG LINGYAN ,  SCARBOROUGH ROBERT M ,  ZUCKETT JINGMEI ,  GOLDMAN ERIC ,  LI WENHAO

IPC: A61K31/18 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/472 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/5513 ,  A61P7/02 ,  A61P9/10 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D277/56 ,  C07D333/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00 ,  C07C

Abstract: Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：AU743614B2

公开(公告)日：2002-01-31

申请号：AU4900397

申请日：1997-10-10

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K31/425 ,  A61K38/05 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P43/00 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07F5/02 ,  C07K5/06 ,  C07K5/097

公开(公告)号：AU6461601A

公开(公告)日：2001-11-26

申请号：AU6461601

申请日：2001-05-16

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT ,  KALARITIS PANOS ,  STEENROD J GUY ,  YIANNIKOUROS GEORGE

IPC: C07D311/58

Abstract: Disclosed are process steps and processes for producing chromane compounds, preferably 2-(6-amino-chroman-2yl) acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.