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公开(公告)号：WO0119798A2
公开(公告)日：2001-03-22
申请号：PCT/US0025195
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D231/00
CPC classification number: C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Compounds of formula A Q D E G J X in which D is a direct link, a substituted or unsubsituted phenyl or naphtyl gourp or a heterocyclic ring system; G is substituted or unsubstituted phenyl or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed, The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 其中D是直接键，取代或未取代的苯基或萘基金属或杂环系的式A Q D E G J X的化合物; G是取代或未取代的苯基或杂环系; X是取代或未取代的苯基或萘基或杂环系; 并且其它变量如权利要求中所定义，其公开的与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0071493A3
公开(公告)日：2002-01-17
申请号：PCT/US0014138
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , ZHAOZHANG JON JIA , SCARBOROUGH ROBERT M , SONG YONGHONG
IPC: A61P7/02 , A61K31/167 , A61K31/18 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/472 , A61K31/4725 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/16 , C07C311/18 , C07C311/40 , C07C311/44 , C07C311/46 , C07D207/16 , C07D217/22 , C07D401/06
CPC classification number: C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0119788A3
公开(公告)日：2001-08-09
申请号：PCT/US0025196
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERIC , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , A61K31/33
CPC classification number: C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Q-D-E-G-J-X的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; X是取代或未取代的苯基或萘基或杂环体系; 并且其它变量如权利要求中所定义，其公开了与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0164642A3
公开(公告)日：2002-05-02
申请号：PCT/US0106247
申请日：2001-02-28
Applicant: COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/18 , A61K31/44 , C07C257/18 , C07D203/18 , C07D205/04 , C07D213/79 , C07D213/80 , C07D231/40 , C07D233/26 , C07D295/18 , C07D317/44 , C07D401/14 , C07D403/12
CPC classification number: A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: Benzamide compounds of formula A-Q-D-E-G-J-X, where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 描述式A-Q-D-E-G-J-X的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0071507A3
公开(公告)日：2001-11-15
申请号：PCT/US0014196
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , ZHAOZHONG JON JIA , SCARBOROUGH ROBERT M , SONG YONGHONG
IPC: A61P7/02 , A61K31/167 , A61K31/18 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/472 , A61K31/4725 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/16 , C07C311/18 , C07C311/40 , C07C311/44 , C07C311/46 , C07D207/16 , C07D217/22 , C07D401/06
CPC classification number: C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物可用于体内或体内用于预防或治疗凝血障碍。
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Patent Agency Ranking
公开(公告)号：WO0112600A9
公开(公告)日：2002-09-12
申请号：PCT/US0021742
申请日：2000-08-10
Applicant: COR THERAPEUTICS INC , ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE
IPC: C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D215/22 , C07D215/227 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D209/04 , C07D215/00 , C07D235/04 , C07D241/36 , C07D403/02 , C07D498/02
CPC classification number: C07D215/227 , C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 式（I）化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0164643A3
公开(公告)日：2002-04-04
申请号：PCT/US0106255
申请日：2001-02-28
Applicant: COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/44
CPC classification number: A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: Benzamide compounds of the formulae (VI) and (VII), where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 描述式（VI）和（VII）的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物可用于体内或体内用于预防或治疗凝血障碍。
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公开(公告)号：WO0047554A3
公开(公告)日：2001-08-09
申请号：PCT/US0003405
申请日：2000-02-11
Applicant: COR THERAPEUTICS INC
Inventor： SONG YONGHONG , ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , JIA ZHAOZHONG JON , SU TING , TENG WILLY
IPC: C07D295/14 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/44 , A61K31/4409 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/517 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P31/04 , A61P43/00 , C07C257/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07D213/56 , C07D213/58 , C07D213/70 , C07D213/74 , C07D213/75 , C07D217/22 , C07D231/12 , C07D233/61 , C07D239/42 , C07D239/94 , C07D257/04 , C07D295/16 , C07D307/54 , C07D401/12 , C07D521/00 , A61K31/16 , A61K31/33 , C07D231/56
CPC classification number: C07D231/12 , C07C311/46 , C07C311/51 , C07C2601/10 , C07D217/22 , C07D233/56 , C07D239/94 , C07D249/08 , C07D307/54 , C07D401/12
Abstract: Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammalian Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 其中A是取代或未取代的苯基，萘基或单环杂环的新型式的化合物，D是取代或未取代的苯基或芳族六元杂环，K是取代或未取代的苯基，萘基或双环杂环，以及 其他变量如权利要求中所定义，公开了其与其相关的盐和其它衍生物和组合物具有抗哺乳动物因子Xa的活性。 固体在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：NO20021229D0
公开(公告)日：2002-03-12
申请号：NO20021229
申请日：2002-03-12
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , HUANG WENRONG , SONG YONGHONG , WANG LINGYAN , SCARBOROUGH ROBERT M , ZUCKETT JINGMEI , GOLDMAN ERIC , LI WENHAO
IPC: A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07C
Abstract: Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AU7486600A
公开(公告)日：2001-04-17
申请号：AU7486600
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M JR
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D231/00
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