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公开(公告)号：WO0071508A3
公开(公告)日：2001-08-23
申请号：PCT/US0014208
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , SCARBOROUH ROBERT M
IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61L31/33 , C07D333/20
CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
Abstract: Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system and the other variables are as defined in the claims, their salts and other derivatives and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：WO0164642A3
公开(公告)日：2002-05-02
申请号：PCT/US0106247
申请日：2001-02-28
Applicant: COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/18 , A61K31/44 , C07C257/18 , C07D203/18 , C07D205/04 , C07D213/79 , C07D213/80 , C07D231/40 , C07D233/26 , C07D295/18 , C07D317/44 , C07D401/14 , C07D403/12
CPC classification number: A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: Benzamide compounds of formula A-Q-D-E-G-J-X, where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 描述式A-Q-D-E-G-J-X的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0071510A3
公开(公告)日：2001-08-30
申请号：PCT/US0014195
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： SU TING , ZHU BING-YAN , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M , ZHANG PENGLIE
IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/33 , C07D207/22 , C07D207/32
CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
Abstract: Compounds of formula A - Y - D - E - G - J - Z - L in which D is direct link, a substutited or unsubstituted phenyl or napththyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Y-D-E-G-J-Z-L的化合物，其中D是直链，取代或未取代的苯基或萘乙基或杂环系统; 并且其它变量如权利要求中所定义，公开了其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0112600A9
公开(公告)日：2002-09-12
申请号：PCT/US0021742
申请日：2000-08-10
Applicant: COR THERAPEUTICS INC , ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE
IPC: C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D215/22 , C07D215/227 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D209/04 , C07D215/00 , C07D235/04 , C07D241/36 , C07D403/02 , C07D498/02
CPC classification number: C07D215/227 , C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 式（I）化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0226712A2
公开(公告)日：2002-04-04
申请号：PCT/US0142352
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC , ZHANG PENGLIE , ZUCKETT JINGMEI FAN , BAO LIANG , SCARBOROUGH ROBERT M , ZHU BING YAN
Inventor： ZHANG PENGLIE , ZUCKETT JINGMEI FAN , BAO LIANG , SCARBOROUGH ROBERT M , ZHU BING-YAN
IPC: A61P7/00 , C07D213/74 , C07D213/81 , C07D409/12 , C07D213/00
CPC classification number: C07D213/74 , C07D213/81 , C07D409/12
Abstract: Novel quaternary amine-containing compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
Abstract translation: 描述了具有抗哺乳动物因子Xa的活性的新型含季铵化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物可用于体外或体内用于预防或治疗特征在于不希望的血栓形成的哺乳动物的状况。
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Patent Agency Ranking
公开(公告)号：WO0164643A3
公开(公告)日：2002-04-04
申请号：PCT/US0106255
申请日：2001-02-28
Applicant: COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/44
CPC classification number: A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: Benzamide compounds of the formulae (VI) and (VII), where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 描述式（VI）和（VII）的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物可用于体内或体内用于预防或治疗凝血障碍。
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公开(公告)号：WO0119788A3
公开(公告)日：2001-08-09
申请号：PCT/US0025196
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERIC , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , A61K31/33
CPC classification number: C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Q-D-E-G-J-X的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; X是取代或未取代的苯基或萘基或杂环体系; 并且其它变量如权利要求中所定义，其公开了与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0071511A3
公开(公告)日：2001-08-09
申请号：PCT/US0014205
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： SU TING , ZHU BING-YAN , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M , ZHANG PENGLIE
IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/277 , A61K31/501
CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
Abstract: Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; Z is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Y-D-E-G-J-Z-L的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; Z是取代或未取代的苯基或萘基或杂环系; 并且其它变量如权利要求中所定义，公开了其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：CA2401778C
公开(公告)日：2010-12-21
申请号：CA2401778
申请日：2001-02-28
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: C07D213/75 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00
Abstract: Benzamide compounds of the formulae (VI) and (VII), where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：BR0107282A
公开(公告)日：2004-07-06
申请号：BR0107282
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , LI WENHAO , GOLDMAN ERICK A , ZHANG PENGLIE , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M
IPC: C07D241/06 , A61K31/438 , A61K31/495 , A61K31/496 , A61P7/02 , A61P9/00 , A61P9/10 , C07D241/08 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/10 , C07D491/113 , C07D401/12
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