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公开(公告)号：WO0164643A3
公开(公告)日：2002-04-04
申请号：PCT/US0106255
申请日：2001-02-28
Applicant: COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/44
CPC classification number: A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: Benzamide compounds of the formulae (VI) and (VII), where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 描述式（VI）和（VII）的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物可用于体内或体内用于预防或治疗凝血障碍。
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公开(公告)号：WO0164642A3
公开(公告)日：2002-05-02
申请号：PCT/US0106247
申请日：2001-02-28
Applicant: COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/18 , A61K31/44 , C07C257/18 , C07D203/18 , C07D205/04 , C07D213/79 , C07D213/80 , C07D231/40 , C07D233/26 , C07D295/18 , C07D317/44 , C07D401/14 , C07D403/12
CPC classification number: A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: Benzamide compounds of formula A-Q-D-E-G-J-X, where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 描述式A-Q-D-E-G-J-X的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0119788A3
公开(公告)日：2001-08-09
申请号：PCT/US0025196
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERIC , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC: A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , A61K31/33
CPC classification number: C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Q-D-E-G-J-X的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; X是取代或未取代的苯基或萘基或杂环体系; 并且其它变量如权利要求中所定义，其公开了与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0071516B1
公开(公告)日：2001-03-01
申请号：PCT/US0014209
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , WANG LINGYAN
IPC: A61K31/155 , A61K31/18 , A61K31/275 , A61K31/401 , A61K31/402 , A61K31/451 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D401/04 , C07D403/04 , C07D413/04 , A61K31/40 , A61P7/00 , C07C311/39
CPC classification number: C07D401/04 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D403/04 , C07D413/04
Abstract: Compounds, e.g. described in claim 5, formula (I) and formula (II), where A-B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 化合物，例如 如权利要求5，式（I）和式（II）所述，其中A-B是（1），公开了它们的盐和与其有关的组合物，其具有抗哺乳动物因子Xa的活性。 这些化合物可用于体外或体内用于预防或治疗凝血病症。
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公开(公告)号：WO0071516A2
公开(公告)日：2000-11-30
申请号：PCT/US0014209
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , WANG LINGYAN
IPC: A61K31/155 , A61K31/18 , A61K31/275 , A61K31/401 , A61K31/402 , A61K31/451 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D207/00
CPC classification number: C07D401/04 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D403/04 , C07D413/04
Abstract: Compounds, e.g. described in claim 5, formula (I) and formula (II), where A-B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 化合物，例如 在其中A-B为（1）的权利要求5所述的式（I）和式（II）中，其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物可用于体内或体内用于预防或治疗凝血障碍。
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Patent Agency Ranking
公开(公告)号：AU1454602A
公开(公告)日：2002-04-08
申请号：AU1454602
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC
Inventor： ZHANG PENGLIE , LI WENHAO , HUANG WENRONG , WANG LINGYAN , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M JR , ZHU BING-YAN
IPC: A61P7/02 , C07D239/91 , C07D401/04 , C07D401/14 , C07D409/14 , C07D487/04 , A61K31/517 , A61K31/519
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公开(公告)号：AU1770001A
公开(公告)日：2001-06-04
申请号：AU1770001
申请日：2000-11-17
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , WANG LINGYAN , HUANG WENRONG , WU YANHONG , FAN JINGMEI , SU TING , SCARBOROUGH ROBERT
IPC: C07D213/75 , A61K31/18 , A61K31/198 , A61K31/223 , A61K31/40 , A61K31/44 , A61K31/4545 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/46 , C07D207/04 , C07D213/81 , C07D295/185 , C07D295/18 , C07D409/12
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公开(公告)号：CA2371904A1
公开(公告)日：2000-11-30
申请号：CA2371904
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , WANG LINGYAN
IPC: A61K31/155 , A61K31/18 , A61K31/275 , A61K31/401 , A61K31/402 , A61K31/451 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D401/04 , C07D403/04 , C07D413/04 , A61K31/40 , A61P7/00 , C07C311/39
Abstract: Compounds, e.g. described in claim 5, formula (I) and formula (II), where A- B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：NO20021229D0
公开(公告)日：2002-03-12
申请号：NO20021229
申请日：2002-03-12
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , HUANG WENRONG , SONG YONGHONG , WANG LINGYAN , SCARBOROUGH ROBERT M , ZUCKETT JINGMEI , GOLDMAN ERIC , LI WENHAO
IPC: A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07C
Abstract: Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AU5284000A
公开(公告)日：2000-12-12
申请号：AU5284000
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M JR , WANG LINGYAN
IPC: A61K31/155 , A61K31/18 , A61K31/275 , A61K31/401 , A61K31/402 , A61K31/451 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D207/00
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