公开(公告)号：WO2017119628A1

公开(公告)日：2017-07-13

申请号：PCT/KR2016/014761

申请日：2016-12-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： CHUNG, Hak Suk ,  YANG, Eun Gyeong ,  HWANG, Dohyeon

IPC: C12N15/63 ,  C12P7/64 ,  C12P19/04 ,  C12N9/10 ,  C12N9/18

CPC classification number: C12N15/70 ,  C12N9/1029 ,  C12N9/16 ,  C12N15/52 ,  C12N15/74 ,  C12P19/12

Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.

Abstract translation: 提供了产生单磷酰脂质A（MLA）的细菌，其包含增加编码LpxE多肽的基因表达的基因修饰和产生MLA的方法。 根据本发明，MLA可以以简单的方式生产，不需要酸水解和/或碱水解。

公开(公告)号：WO2017095136A1

公开(公告)日：2017-06-08

申请号：PCT/KR2016/013956

申请日：2016-11-30

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  PHAROSGEN ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： BYUN, Young Ro ,  KIM, In San ,  TASLIM, Ahmed Al-Hilal ,  KIM, Sang Yoon ,  JANG, Ye Ji

IPC: A61K31/727 ,  A61K39/395 ,  A61K48/00 ,  C07K14/705 ,  C07H3/06 ,  C07K16/28 ,  C07K16/30 ,  C12N15/113

CPC classification number: C07K16/2872 ,  A61K31/727 ,  A61K47/554 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3515 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/705

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

Abstract translation: 本文描述了用于抑制病理性血管生成和治疗与病理性血管生成相关的疾病和病症的多巴靶向分子，所述疾病和病症例如肿瘤，癌症，动脉粥样硬化，肺结核，哮喘，肺动脉高血压（PAH），肿瘤 和肿瘤相关的病症，并用于检测受试者中的doppel表达。 还描述了相关的组合物和方法。

公开(公告)号：WO2013058545A1

公开(公告)日：2013-04-25

申请号：PCT/KR2012/008485

申请日：2012-10-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： PARK, Ji Hyung ,  YOON, Dong Wook ,  LEE, Joong Ho

IPC: G06F3/14 ,  G06F3/03

CPC classification number: G06F3/04883 ,  G09G2354/00 ,  G09G2380/14

Abstract: Disclosed are an electronic book apparatus and a user interface providing method of the same. The electronic book apparatus includes: a sensor unit for sensing an input to the electronic book apparatus; a gesture processing unit for generating gesture information, which changes an output format of an electronic book having a plurality of pages, by using the sensed input; a rendering unit for generating an output image of the electronic book based on the gesture information; and a display unit for displaying the output image.

Abstract translation: 公开了一种电子书籍装置及其用户界面提供方法。 电子书本装置包括：传感器单元，用于感测对电子书籍装置的输入; 手势处理单元，用于通过使用所感测的输入来生成改变具有多页的电子书的输出格式的手势信息; 渲染单元，用于基于所述手势信息生成所述电子书的输出图像; 以及用于显示输出图像的显示单元。

公开(公告)号：WO2012150834A2

公开(公告)日：2012-11-08

申请号：PCT/KR2012/003496

申请日：2012-05-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  JO, Han Ik ,  LEE, Sung Ho ,  KU, Bon Cheol ,  KIM, Jun Kyung ,  KIM, Tae Wook ,  HWANG, Sang Youp

Inventor： JO, Han Ik ,  LEE, Sung Ho ,  KU, Bon Cheol ,  KIM, Jun Kyung ,  KIM, Tae Wook ,  HWANG, Sang Youp

IPC: C01B31/02 ,  B32B33/00 ,  B01J19/08 ,  H01B1/04

CPC classification number: B82Y30/00 ,  B82Y40/00 ,  C01B32/184 ,  C01B32/186 ,  C01B32/20 ,  Y10T428/24975 ,  Y10T428/261

Abstract: Provided is a preparation method for carbon materials, carbon materials prepared from the same, and a product including the carbon materials, in which the preparation method including forming a polymer layer containing a polymer, stabilizing the polymer layer to form a cyclized aromatic structure of carbon atoms in the polymer, and carbonizing the stabilized polymer layer.

Abstract translation: 提供一种碳材料的制备方法，由该碳材料制备的碳材料和包含碳材料的产品，其中制备方法包括形成含有聚合物的聚合物层，稳定聚合物层以形成碳环化芳族结构 聚合物中的原子，并将稳定的聚合物层碳化。

公开(公告)号：WO2011115353A1

公开(公告)日：2011-09-22

申请号：PCT/KR2010/008502

申请日：2010-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  HAN, Kyoung Ran ,  PARK, Sang Whan ,  KIM, Chang Sam ,  YANG, Jin Oh

Inventor： HAN, Kyoung Ran ,  PARK, Sang Whan ,  KIM, Chang Sam ,  YANG, Jin Oh

IPC: C04B35/101 ,  C04B35/565 ,  C04B35/657 ,  C04B28/00

CPC classification number: C04B35/66 ,  C04B35/565 ,  C04B35/6303 ,  C04B35/63416 ,  C04B35/6365 ,  C04B2235/3206 ,  C04B2235/3217 ,  C04B2235/3218 ,  C04B2235/322 ,  C04B2235/3222 ,  C04B2235/3244 ,  C04B2235/3826 ,  C04B2235/5427 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/5472 ,  C04B2235/77 ,  C04B2235/96

Abstract: Provided are an alumina-bonded unshaped refractory and a method for manufacturing the same. The disclosed alumina-bonded unshaped refractory includes Al 2 O 3 , SiC, alumina precursor powder and water. The alumina-bonded unshaped refractory has sufficient strength, experiences little contraction after heat treatment and exhibits low porosity and high strength, without using cement.

Abstract translation: 提供一种氧化铝键合的不定形耐火材料及其制造方法。 所公开的氧化铝粘结的非成型耐火材料包括Al 2 O 3，SiC，氧化铝前体粉末和水。 氧化铝粘结的非成形耐火材料具有足够的强度，热处理后几乎没有收缩，并且不使用水泥而显示低孔隙率和高强度。

公开(公告)号：WO2011108782A1

公开(公告)日：2011-09-09

申请号：PCT/KR2010/004576

申请日：2010-07-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  YOON, Eui Sung ,  YANG, Sung Wook ,  KIM, Jin Seok ,  NA, Kyoung Hwan ,  RHO, Duk Moon

Inventor： YOON, Eui Sung ,  YANG, Sung Wook ,  KIM, Jin Seok ,  NA, Kyoung Hwan ,  RHO, Duk Moon

IPC: B25J7/00 ,  B25J18/06 ,  B25J19/00

CPC classification number: B25J18/06 ,  A61B1/00156 ,  A61B1/041 ,  A61B34/72 ,  A61B2034/303 ,  B25J7/00

Abstract: Disclosed herein is a bidirectional moving micro-robot system. The bidirectional moving micro-robot system has a first body having a plurality of legs foldably/unfoldably connected thereto, a second body having a plurality of legs foldably/unfoldably connected thereto and a connection member having both end portions respectively connected to the first and second bodies. In the bidirectional moving micro-robot system, the length of the connection member exposed between the first and second bodies is extended or contracted.

Abstract translation: 这里公开了一种双向移动微机器人系统。 双向移动微机器人系统具有可折叠/不可折叠地连接到其上的多个腿部的第一主体，具有可折叠/不可折叠地连接到其上的多个腿部的第二主体和具有分别连接到第一和第二部分的两个端部的连接构件 身体。 在双向移动微机器人系统中，暴露在第一和第二主体之间的连接构件的长度被延伸或收缩。

公开(公告)号：WO2011105665A1

公开(公告)日：2011-09-01

申请号：PCT/KR2010/004850

申请日：2010-07-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  CHOI, Ji Hyun ,  SHIN, Hee Sup ,  SUNG, Ho Kun ,  KIM, Shin Keun ,  SONG, Ho Young

Inventor： CHOI, Ji Hyun ,  SHIN, Hee Sup ,  SUNG, Ho Kun ,  KIM, Shin Keun ,  SONG, Ho Young

IPC: H01L21/288

CPC classification number: C25D7/123 ,  A61N1/0529 ,  H01L23/3192 ,  H01L24/03 ,  H01L24/05 ,  H01L24/06 ,  H01L24/11 ,  H01L24/13 ,  H01L2224/0345 ,  H01L2224/03466 ,  H01L2224/03515 ,  H01L2224/0362 ,  H01L2224/03831 ,  H01L2224/0401 ,  H01L2224/05572 ,  H01L2224/05655 ,  H01L2224/05666 ,  H01L2224/05671 ,  H01L2224/0603 ,  H01L2224/11462 ,  H01L2224/11622 ,  H01L2224/11903 ,  H01L2224/13018 ,  H01L2224/13019 ,  H01L2224/13082 ,  H01L2224/13139 ,  H01L2224/13144 ,  H01L2224/13147 ,  H01L2224/13155 ,  H01L2224/13169 ,  H01L2224/1403 ,  H01L2924/0002 ,  H01L2924/01029 ,  H01L2924/01074 ,  H01L2924/01027 ,  H01L2224/05552 ,  H01L2924/00012

Abstract: Disclosed herein is a processing method of a microelectrode array. A processing method of a microelectrode array includes: depositing a sacrificial layer on a silicon substrate; patterning a first polymer on the deposited sacrificial layer and then thermally curing the first polymer patterning a metal thin film on the first polymer to form a bonding pad site, an interconnection line and a recording pad site; closing the interconnection line site and coating a second polymer to pattern the bonding pad site and the recording pad site; depositing a seed layer on the second polymer and the metal thin film using a sputter; electroplating a metal on the bonding pad site and the recording pad site, thereby forming an electroplated layer; patterning a photoresist to open an upper portion of the electroplated layer; depositing platinum on the photoresist and the electroplated layer; and removing the photoresist.

Abstract translation: 这里公开了微电极阵列的处理方法。 微电极阵列的处理方法包括：在硅衬底上沉积牺牲层; 在沉积的牺牲层上图案化第一聚合物，然后热固化第一聚合物图案化第一聚合物上的金属薄膜以形成接合焊盘部位，互连线和记录垫部位; 闭合互连线部位并涂覆第二聚合物以对接合焊盘部位和记录焊盘部位进行图案化; 使用溅射将种子层沉积在第二聚合物和金属薄膜上; 在焊盘位置和记录垫部位电镀金属，由此形成电镀层; 图案化光致抗蚀剂以打开电镀层的上部; 在光致抗蚀剂和电镀层上沉积铂; 并去除光致抗蚀剂。

公开(公告)号：WO2010110596A2

公开(公告)日：2010-09-30

申请号：PCT/KR2010/001807

申请日：2010-03-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KIM, Sang-Heon ,  KIM, Soo Hyun ,  PARK, In Su ,  JUNG, Young Mee

Inventor： KIM, Sang-Heon ,  KIM, Soo Hyun ,  PARK, In Su ,  JUNG, Young Mee

IPC: C12N5/071 ,  C12N5/074 ,  C12N5/02 ,  C07K14/475 ,  A61P9/00 ,  A61L27/38

CPC classification number: C12N5/0667 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/507 ,  A61L27/58 ,  C12N5/069 ,  C12N2506/1384 ,  C12N2533/30 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/70

Abstract: The present invention relates to a method for differentiating stem cells into vascular cells by culturing them in the form of a three-dimensional cell cluster and the use of the three-dimensional cell cluster for angiogenesis. Specifically, the present invention teaches a method for differentiating stem cells into vascular cells comprising culturing stem cells by adhering them onto a culture plate with a surface having a hydrophobic property or a culture plate onto which a growth factor is immobilized, wherein the cultured stem cells are later detached from the culture plate as their density increases to form a three-dimensional cell cluster and grown in the form of a three-dimensional cell cluster while differentiating into vascular cells. Also disclosed is the use of a three-dimensional cell cluster composed of the vascular cells differentiated from stem cells by the above method as a cell therapy agent for angiogenesis.

Abstract translation: 本发明涉及一种通过以三维细胞簇的形式培养它们并使用三维细胞簇进行血管发生来将干细胞分化为血管细胞的方法。 具体而言，本发明教导了将干细胞分化为血管细胞的方法，包括通过将干细胞粘附到具有疏水性的表面的培养板上或培养板上固定有生长因子培养干细胞，其中培养的干细胞 随着其密度增加而随培养板分离，形成三维细胞簇，并以三维细胞簇的形式生长，同时分化为血管细胞。 还公开了通过上述方法将由干细胞分化的血管细胞组成的三维细胞簇用作血管发生的细胞治疗剂。

公开(公告)号：WO2010062116A2

公开(公告)日：2010-06-03

申请号：PCT/KR2009/006996

申请日：2009-11-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Kyeong Seok ,  KIM, Won Mok ,  LEE, Taek Sung ,  CHEONG, Byung Ki

Inventor： LEE, Kyeong Seok ,  KIM, Won Mok ,  LEE, Taek Sung ,  CHEONG, Byung Ki

IPC: G01N21/55 ,  G01N21/25 ,  G01N21/00 ,  G01N33/50

CPC classification number: G01N21/553

Abstract: Provided is a surface plasmon resonance sensor including: a part of delivering light by which a signal beam is incident to generate an evanescent field; and a part of exciting surface plasmon for exciting surface plasmons by the generated evanescent field and giving rise to a surface plasmon resonance, wherein a dielectric waveguide layer is inserted between metal layers of the part of exciting surface plasmon, and surface plasmon resonance properties are changed by an object to be analyzed.

Abstract translation: 提供了一种表面等离子体共振传感器，包括：传输信号光束入射的光以产生ev逝场的一部分; 以及激发表面等离子体的一部分，用于通过产生的ev逝场激发表面等离子体激元，并引起表面等离子体共振，其中介电波导层插入在激发表面等离子体激元的一部分的金属层之间，并且表面等离子体共振性质被改变 由待分析的对象。

公开(公告)号：WO2010044557A2

公开(公告)日：2010-04-22

申请号：PCT/KR2009/005570

申请日：2009-09-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KIM, Il Doo

Inventor： KIM, Il Doo

IPC: H01M4/02

CPC classification number: H01M4/1391 ,  H01M4/0419 ,  H01M4/043 ,  H01M4/0471 ,  H01M4/131 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/5825 ,  H01M2004/021 ,  Y02E60/122

Abstract: The present invention relates to an electrode for a secondary battery, comprising a collector and a porous electrode active material layer disposed on at least one surface of the collector by spraying metal oxide nanoparticle dispersion, wherein the porous electrode active material comprises one selected from the group consisting of aggregated metal oxide nanoparticles, metal oxide nanoparticles and a mixture thereof, which is capable of undergoing stable high speed charging/discharging cycles under a high-energy-density and high-current condition.

Abstract translation: 二次电池用电极技术领域本发明涉及一种二次电池用电极，其特征在于，包括通过喷射金属氧化物纳米粒子分散体而设置在集电体的至少一个表面上的集电体和多孔电极活性物质层，其中，所述多孔电极活性物质包含选自 由聚集的金属氧化物纳米颗粒，金属氧化物纳米颗粒及其混合物组成，其能够在高能量密度和高电流条件下经历稳定的高速充电/放电循环。