公开(公告)号：WO2017119628A1

公开(公告)日：2017-07-13

申请号：PCT/KR2016/014761

申请日：2016-12-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： CHUNG, Hak Suk ,  YANG, Eun Gyeong ,  HWANG, Dohyeon

IPC: C12N15/63 ,  C12P7/64 ,  C12P19/04 ,  C12N9/10 ,  C12N9/18

CPC classification number: C12N15/70 ,  C12N9/1029 ,  C12N9/16 ,  C12N15/52 ,  C12N15/74 ,  C12P19/12

Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.

Abstract translation: 提供了产生单磷酰脂质A（MLA）的细菌，其包含增加编码LpxE多肽的基因表达的基因修饰和产生MLA的方法。 根据本发明，MLA可以以简单的方式生产，不需要酸水解和/或碱水解。

公开(公告)号：EP3400303A1

公开(公告)日：2018-11-14

申请号：EP16884011.4

申请日：2016-12-16

Applicant: Korea Institute of Science and Technology

Inventor： CHUNG, Hak Suk ,  YANG, Eun Gyeong ,  HWANG, Dohyeon

IPC: C12N15/63 ,  C12P7/64 ,  C12P19/04 ,  C12N9/10 ,  C12N9/18

CPC classification number: C12N15/70 ,  C12N9/1029 ,  C12N9/16 ,  C12N15/52 ,  C12N15/74 ,  C12P19/12

Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.