-
Patent Agency Ranking1.发明申请
公开(公告)号：WO2019009593A2
公开(公告)日：2019-01-10
申请号：PCT/KR2018/007526
申请日：2018-07-03
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： CHUNG, Hak Suk , JI, Yu Hyun , AN, Jin Su , KWON, Ick Chan , YANG, Eun Gyeong
Abstract: A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.
-
2.发明申请BACTERIUM PRODUCING MONOPHOSPHORYL LIPID A AND METHOD OF PRODUCING MONOPHOSPHORYL LIPID A BY USING BACTERIUM 审中-公开产生单磷酸脂A的细菌及利用细菌生产单磷酸甘油酯A的方法
公开(公告)号：WO2017119628A1
公开(公告)日：2017-07-13
申请号：PCT/KR2016/014761
申请日：2016-12-16
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： CHUNG, Hak Suk , YANG, Eun Gyeong , HWANG, Dohyeon
Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.
Abstract translation: 提供了产生单磷酰脂质A（MLA）的细菌，其包含增加编码LpxE多肽的基因表达的基因修饰和产生MLA的方法。 根据本发明，MLA可以以简单的方式生产，不需要酸水解和/或碱水解。
-
3.发明申请
公开(公告)号：WO2008111818A1
公开(公告)日：2008-09-18
申请号：PCT/KR2008/001459
申请日：2008-03-14
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , AHN, Dae-Ro , YANG, Eun Gyeong
Inventor： AHN, Dae-Ro , YANG, Eun Gyeong
IPC: C12Q1/68
CPC classification number: G01N33/68 , C12N15/111 , C12N15/115 , C12N2310/16 , C12N2320/10 , C12Q1/682 , C12Q1/6823 , G01N2500/00 , C12Q2525/205 , C12Q2525/161 , C12Q2521/301 , C12Q2565/1015
Abstract: A method and a kit for detecting a target protein in a sample with a signal amplification strategy are provided. The signal amplification strategy is established for the aptamer-based molecular recognition of a target protein with concomitant release of single-stranded DNA (G-DNA), which binds complementarily to a single-stranded RNA comprising a fluorophore and a quencher ("F-RNA-Q"). The fluorescence-quenched RNA is then degraded by RNase H to result in a fluorescence signal, and the undamaged G-DNA is recycled to yield fluorescence amplification.
Abstract translation: 提供了一种利用信号放大策略检测样品中靶蛋白的方法和试剂盒。 建立信号放大策略，用于靶蛋白的适体分子识别，并伴随释放单链DNA（G-DNA），其与包含荧光团和猝灭剂的单链RNA互补结合（“F- RNA-Q“）。 然后荧光淬灭的RNA被RNase H降解以产生荧光信号，并且未损坏的G-DNA被再循环以产生荧光扩增。
-
4.发明公开
公开(公告)号：EP3649244A2
公开(公告)日：2020-05-13
申请号：EP18828686.8
申请日：2018-07-03
Applicant: Korea Institute of Science and Technology
Inventor： CHUNG, Hak Suk , JI, Yuhyun , AN, Jinsu , KWON, Ick Chan , YANG, Eun Gyeong
-
5.发明公开
公开(公告)号：EP3400303A1
公开(公告)日：2018-11-14
申请号：EP16884011.4
申请日：2016-12-16
Applicant: Korea Institute of Science and Technology
Inventor： CHUNG, Hak Suk , YANG, Eun Gyeong , HWANG, Dohyeon
Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.
-
-
-
-
Search Results
5
records
(took 0.03 seconds)
