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    METHODS FOR SCREENING VIRAL LIKE PARTICLES AND IDENTIFYING NEUTRALIZING EPITOPES AND RELATED VACCINES, CONSTRUCTS, AND LIBRARIES
    102.
    发明申请
    METHODS FOR SCREENING VIRAL LIKE PARTICLES AND IDENTIFYING NEUTRALIZING EPITOPES AND RELATED VACCINES, CONSTRUCTS, AND LIBRARIES 审中-公开
    筛选病毒颗粒和识别中性疱疹病毒和相关疫苗，构造和图像的方法

    公开(公告)号：WO2013063366A3

    公开(公告)日：2013-07-11

    申请号：PCT/US2012062073

    申请日：2012-10-26

    Applicant: STC UNM

    Inventor： HJELLE BRIAN L ,  PEABODY DAVID S ,  CHACKERIAN BRYCE

    IPC: G01N33/68 ,  C12Q1/68 ,  G01N33/569

    CPC classification number: G01N33/6878 ,  G01N33/56983 ,  G01N33/6845

    Abstract: The invention is directed to methods of screening immunogenic viral like particles and related immunogenic compositions and diagnostic techniques. In one embodiment, the invention provides methods of screening immunogenic viral like particles containing peptides corresponding to epitope regions of a wide variety of pathogens, including viruses, bacteria, parasites, and microbes. Non-infectious antigens and allergens of interest can also be screened as described herein. Immunization, therapeutic and diagnostic applications are also described for the compositions and methods according to the invention. In another embodiment, the invention provides novel methods of identifying a cryptic neutralizing epitope and related vaccines, constructs, and libraries. In some embodiments, these methods use high-throughput formats that are facilitated by in silica or in vitro steps.

    Abstract translation: 本发明涉及筛选免疫原性病毒样颗粒和相关的免疫原性组合物和诊断技术的方法。 在一个实施方案中，本发明提供筛选含有对应于多种病原体（包括病毒，细菌，寄生虫和微生物）的表位区域的肽的免疫原性病毒样颗粒的方法。 还可以如本文所述筛选感兴趣的非传染性抗原和过敏原。 还描述了根据本发明的组合物和方法的免疫，治疗和诊断应用。 在另一个实施方案中，本发明提供鉴定隐性中和表位和相关疫苗，构建体和文库的新方法。 在一些实施方案中，这些方法使用通过二氧化硅或体外步骤促进的高通量形式。

    DRY POWDER NEBULIZER
    105.
    发明申请
    DRY POWDER NEBULIZER 审中-公开
    干粉底泥

    公开(公告)号：WO2011112531A3

    公开(公告)日：2012-01-05

    申请号：PCT/US2011027465

    申请日：2011-03-08

    Applicant: STC UNM ,  MAYNARD NICOLA JEANNE ,  SMYTH HUGH D C

    Inventor： MAYNARD NICOLA JEANNE ,  SMYTH HUGH D C

    IPC: A61M11/02 ,  A61J1/05 ,  A61M15/00

    CPC classification number: A61M15/0086 ,  A61M11/003 ,  A61M15/00 ,  A61M15/0006 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/009 ,  A61M2016/0015 ,  A61M2202/064 ,  A61M2205/0272 ,  A61M2205/8287 ,  A61M2206/16

    Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically- responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

    Abstract translation: 干粉递送装置可以被配置为向使用者的气道提供微粉化的干粉颗粒。 该装置可以包括限定包含至少一个磁响应物体的腔室的圆柱形容器，在该腔室外部的电动机，该腔室外部的磁体并与该电动机可旋转地联接，以及流出部件，其将气流引导至使用者 。 磁性响应物体可以涂覆有微粉化的干粉末颗粒，并且电动机可操作以使磁体围绕轴线旋转。 磁体的旋转产生磁场，使得响应于磁场的磁响应物体移动并与容器的侧壁碰撞，以使干粉颗粒解聚并使空腔中的干粉雾化。

    POLONY SEQUENCING METHODS
    106.
    发明申请
    POLONY SEQUENCING METHODS 审中-公开
    POLONY测序方法

    公开(公告)号：WO2011044437A3

    公开(公告)日：2011-11-03

    申请号：PCT/US2010051938

    申请日：2010-10-08

    Applicant: STC UNM ,  EDWARDS JEREMY

    Inventor： EDWARDS JEREMY

    IPC: C12N15/10 ,  C12N15/11 ,  C12Q1/68 ,  C40B40/06

    CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  C12Q2525/155 ,  C12Q2521/313 ,  C12Q2565/518 ,  C12Q2563/131 ,  C12Q2525/191

    Abstract: We describe ultra-high throughput polony genome sequencing that can permit, for example, generating raw data to re-sequencing the human genome in about one week (including library prep and sequencing) at a reasonable cost. The methods described herein include one or more of the following: (1) increasing polony sequencing read length, (2) improving library construction and emulsions protocols, (3) increasing bead density and/or moving to alternative clonal amplication strategies (other than emulsion PCR or ePCR), (4) extending software capabilities to allow SNP calls from our new sequencing raw data, (5) Dual Primer Emulsion PCR, and (6) diagnostic method exploiting one or more of the foregoing.

    Abstract translation: 我们描述了超高通量的基因组测序，可以允许例如生成原始数据，以合理的成本在约一周（包括文库制备和测序）中重新测序人类基因组。 本文所述的方法包括以下中的一种或多种：（1）增加聚​​合酶测序阅读长度，（2）改进文库构建和乳液方案，（3）增加珠密度和/或转向替代克隆扩增策略 PCR或ePCR），（4）扩展软件功能以允许来自我们新的测序原始数据的SNP调用，（5）双引物乳液PCR和（6）利用上述一种或多种的诊断方法。

    SYSTEM AND METHODS FOR AUTOMATIC PLACEMENT OF SPATIAL SUPRESSION REGIONS IN MRI AND MRSI
    109.
    发明申请
    SYSTEM AND METHODS FOR AUTOMATIC PLACEMENT OF SPATIAL SUPRESSION REGIONS IN MRI AND MRSI 审中-公开
    用于自动放置MRI和MRSI中的空间区域的系统和方法

    公开(公告)号：WO2011050348A2

    公开(公告)日：2011-04-28

    申请号：PCT/US2010053885

    申请日：2010-10-24

    Applicant: STC UNM ,  POSSE STEFAN ,  VAN DER KOUWE ANDRE ,  GAO KUNXIU

    Inventor： POSSE STEFAN ,  VAN DER KOUWE ANDRE ,  GAO KUNXIU

    IPC: A61B5/055

    CPC classification number: G01R33/4838 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/5607

    Abstract: A system and methods for imaging a patient organ. The system includes a MRI imaging apparatus communicating with a memory and processor. The method aligns the organ with a standardized organ, and includes a step of spatially normalizing the standardized organ to the patient organ. The method also provides optimized slices of the standardized organ and translates optimized slices of standardized organ into optimized slices of the patient organ. The method images the patient organ according to the optimized slices of the patient organ.

    Abstract translation: 用于成像患者器官的系统和方法。 该系统包括与存储器和处理器通信的MRI成像设备。 该方法使器官与标准化器官对齐，并且包括将标准化器官空间归一化到患者器官的步骤。 该方法还提供了标准化器官的优化切片，并将优化的标准化器官切片转化为患者器官的优化切片。 该方法根据患者器官的优化切片对患者器官进行成像。

    STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES AND THEIR USE IN ACOUSTIC RADIATION FIELDS
    110.
    发明申请
    STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES AND THEIR USE IN ACOUSTIC RADIATION FIELDS 审中-公开
    稳定的弹性体负反射粒子及其在声辐射场中的应用

    公开(公告)号：WO2010132474A3

    公开(公告)日：2011-04-21

    申请号：PCT/US2010034415

    申请日：2010-05-11

    Applicant: STC UNM ,  LOPEZ GABRIEL ,  KADUCHAK GREGORY

    Inventor： LOPEZ GABRIEL ,  KADUCHAK GREGORY

    IPC: A61K9/14 ,  A61K9/16 ,  A61K47/30 ,  A61K49/00

    CPC classification number: C08L83/04 ,  A61K9/0009 ,  A61K9/1641 ,  A61K9/1682 ,  A61K47/34 ,  A61K49/225 ,  G01N33/538 ,  G01N33/54313

    Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.

    Abstract translation: 我们描述了具有可压缩性和密度的稳定的弹性体负声学对比粒子的合成方法和配方。 这些弹性体负声学对比颗粒的密度/压缩比小于水的密度/压缩比，因此在声辐射暴露下呈现负的声学对比度。 这种负声学对比度允许我们的弹性体负声学对比粒子与水溶液中的其它组分（例如细胞）不同地被声学操纵（例如分离）。 本公开还描述了弹性体负声学对比粒子的生物功能化的方法，并且作为其用作生物测定平台的实例。 这些弹性体负声学对比粒子的潜在应用包括基于声流式细胞术的敏感生物测定和利用声场的其他类型的技术，包括超声成像和超声触发药物递送。

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