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公开(公告)号：KR1020140070474A
公开(公告)日：2014-06-10
申请号：KR1020130147705
申请日：2013-11-29
Applicant: (주)아모레퍼시픽
IPC: C07C235/08 , A61K31/164 , A61P17/16
CPC classification number: A61K8/42 , A61K8/68 , A61K2800/40 , A61Q19/007 , C07C233/18 , C07C235/08 , C07C235/28
Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer, a pharmaceutically allowable salt, a pro-drug, a hydroxide, or a solvated compound thereof. [Chemical Formula 1] (In Chemical Formula 1, R1 and R2 are independently non-substituted or hydroxyl group-substituted C 9 to 23 saturated or unsaturated aliphatic chains.) According to the present invention, the compound has excellent stability and dissolubility and is effective in moisturizing the skin so as to protect the skin from external stimuli without side effects and be used as an active ingredient for recovering damaged skin and preventing skin damage. Accordingly, the compound can be used as an external skin application composition for moisturizing the skin, as a cosmetic composition, or as a pharmaceutical composition.
Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，异构体，药学上可允许的盐，前药，氢氧化物或溶剂化物。 [化学式1]
（在化学式1中，R1和R2分别为非 取代或羟基取代的C 9〜23饱和或不饱和脂肪链）根据本发明，该化合物具有优异的稳定性和溶解性，并且有效地保湿皮肤，从而保护皮肤免受外部刺激而没有副作用 并用作恢复受损皮肤并防止皮肤损伤的活性成分。 因此，该化合物可以用作皮肤保湿剂，化妆品组合物或作为药物组合物的外用皮肤施用组合物。
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公开(公告)号：KR1020140069916A
公开(公告)日：2014-06-10
申请号：KR1020120137787
申请日：2012-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/0241 , A61K8/26 , A61K8/29 , A61K8/8152 , A61K49/0423 , A61K2800/624 , A61K2800/651 , A61Q1/12 , A61Q17/04 , A61Q19/00 , B82Y5/00
Abstract: The present invention relates to an inorganic powder coated with a biocompatible polymer and a cosmetic composition containing the same, and more specifically, to an inorganic-organic hybrid powder having improved dispersibility and tactile sensation by treating a rough surface of an inorganic powder with a biocompatible polymer, and to a cosmetic composition having improved tactile sensation and adhesiveness when applied to the skin by containing the hybrid powder.
Abstract translation: 本发明涉及涂覆有生物相容性聚合物的无机粉末和含有它的化妆品组合物，更具体地说，涉及通过用生物相容性处理无机粉末的粗糙表面而具有改善的分散性和触感的无机 - 有机杂化粉末 聚合物，并且通过含有杂化粉末施用于皮肤时具有改善的触觉和粘合性的化妆品组合物。
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公开(公告)号：KR1020140012274A
公开(公告)日：2014-02-03
申请号：KR1020120078675
申请日：2012-07-19
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/145 , A23L29/035 , A23L29/045 , A23L29/055 , A23V2200/318 , A61K8/46 , A61K8/63 , A61K31/575 , A61Q19/02 , G01N33/5044
Abstract: Disclosed are: a skin whitening agent containing a liver X receptor agonist as an effective component; and a screening method of a skin whitening material including a step of checking the promotion degree of liver X receptor expression or activation of cells by a candidate substance. [Reference numerals] (AA,BB) Amount of melanin(%)
Abstract translation: 公开了含有肝X受体激动剂作为有效成分的皮肤增白剂; 以及皮肤美白材料的筛选方法，其包括检查候选物质的肝脏X受体表达的促进度或细胞活化的步骤。 [参考号]（AA，BB）黑色素含量（％）
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公开(公告)号：KR1020130077953A
公开(公告)日：2013-07-10
申请号：KR1020110146636
申请日：2011-12-30
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: Carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is provided to suppress elastase activation or matrix metalloproteinase-9 (MMP) expression, and to basically inhibit vital reaction mediated by the suppression. CONSTITUTION: An elastase activation inhibitor contains carnosic acid of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The carnosic acid derivative is carnosic acid methyl ester or carnosic methyl alcohol. The carnosic acid, the derivative, or the pharmaceutically acceptable salt is derived from rosemary and/or sage. The inhibitor contains 0.0001-20 wt% of the active ingredient. An MMP expression inhibitor contains the carnosic acid, the derivative, or the pharmaceutically acceptable salt as an active ingredient. A composition for skin anti-aging contains the carnosic acid, the derivative, or the pharmaceutically acceptable salt as an active ingredient.
Abstract translation: 目的：为了抑制弹性蛋白酶活化或基质金属蛋白酶-9（MMP）的表达，基本上抑制由抑制介导的生物反应，提供鼠尾草衍生物或其药学上可接受的盐。 构成：弹性蛋白酶活化抑制剂含有化学式1的山梨酸，其衍生物或其药学上可接受的盐作为活性成分。 鼠尾草酸衍生物是鼠尾草酸甲酯或鼠尾草甲醇。 鼠尾草酸，衍生物或药学上可接受的盐衍生自迷迭香和/或鼠尾草。 抑制剂含有0.0001-20重量％的活性成分。 MMP表达抑制剂含有鼠尾草酸，衍生物或药学上可接受的盐作为活性成分。 用于皮肤抗衰老的组合物含有鼠尾草酸，衍生物或药学上可接受的盐作为活性成分。
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公开(公告)号：KR1020130042944A
公开(公告)日：2013-04-29
申请号：KR1020110107117
申请日：2011-10-19
Applicant: (주)아모레퍼시픽
IPC: A61K36/344 , A61K8/97 , A61P17/14 , A61Q7/00
Abstract: PURPOSE: A composition containing an enzyme-treated Codonopsis lanceolata extract is provided to shorten hair growth period, and to promote hair growth. CONSTITUTION: A composition for promoting hair growth contains 0.001-20 wt% of enzyme-treated Codonopsis lanceolata extract as an active ingredient. The extract is treated with a cel-wall decomposing enzyme or a protease. The enzyme is cellulase or pectinase. [Reference numerals] (AA) Example 1; (BB) Comparative example 1;
Abstract translation: 目的：提供一种含有酶处理的党参提取物的组合物，以缩短头发生长期，促进毛发生长。 构成：用于促进毛发生长的组合物含有0.001-20重量％的酶处理的党参提取物作为活性成分。 提取物用纤维素分解酶或蛋白酶处理。 酶是纤维素酶或果胶酶。 （标号）（AA）实施例1; （BB）比较例1;
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Patent Agency Ranking106.发明公开지방산 연장 효소 발현 및 탄소사슬 발현 조절을 통한 아토피성 피부의 피부 장벽 기능 회복 효능 물질 스크리닝 방법 审中-实审通过控制脂肪酸快速表达和碳链表达来控制皮肤粘膜功能恢复原位真皮的候选材料筛选方法
公开(公告)号：KR1020130034169A
公开(公告)日：2013-04-05
申请号：KR1020110098052
申请日：2011-09-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A method for screening a material which recovers skin barrier function of atopic skin through controlling expression of fatty acid elongase and carbon chain is provided to detecting ceramide fatty acid and to accurately screen skin improving substances. CONSTITUTION: A method for screening a material for treating atopic dermatitis comprises: a step of identifying expression level of elongase in keratinocytes treated with candidate materials; and a step of determining a material which enhances the expression level of the elongase as a material which improves atopic dermatitis. [Reference numerals] (AA) Score; (BB) Control group;
Abstract translation: 目的：通过控制脂肪酸延伸酶和碳链的表达来筛选恢复特应性皮肤的皮肤屏障功能的材料，用于检测神经酰胺脂肪酸并准确筛选皮肤改善物质。 构成：筛选用于治疗特应性皮炎的材料的方法包括：鉴定用候选材料处理的角质形成细胞中延伸酶的表达水平的步骤; 以及确定提高延长酶的表达水平的材料作为改善特应性皮炎的材料的步骤。 （附图标记）（AA）得分; （BB）对照组;
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公开(公告)号：KR1020130025074A
公开(公告)日：2013-03-11
申请号：KR1020110088384
申请日：2011-09-01
Applicant: (주)아모레퍼시픽
IPC: A61K31/7034 , A61K8/60 , A61P17/00 , A61Q19/02
CPC classification number: A61K31/7048 , A61K8/602 , A61Q19/02
Abstract: PURPOSE: A composition containing an esculin derivative is provided to suppress tyrosinase activity and melanogenesis and to ensure an excellent skin whitening effect. CONSTITUTION: A composition for skin whitening contains an esculin derivative of chemical formula 1, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof as an active ingredient. In chemical formula 1, R is selected from a group consisting of C1-C30 alkyl, C2-C30 alkene, C3-C30 cycloalkyl, and C1-C30 haloalkyl.
Abstract translation: 目的：提供含有esculin衍生物的组合物以抑制酪氨酸酶活性和黑素生成，并确保优异的皮肤美白效果。 构成：皮肤美白用组合物含有化学式1的衍生物，其异构体，其药学上可接受的盐，其前药，其水合物或其溶剂合物作为活性成分。 在化学式1中，R选自C 1 -C 30烷基，C 2 -C 30烯烃，C 3 -C 30环烷基和C 1 -C 30卤代烷基。
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公开(公告)号：KR100672183B1
公开(公告)日：2007-02-28
申请号：KR1020050078842
申请日：2005-08-26
Applicant: (주)아모레퍼시픽
Inventor： 서영거 , 오우택 , 김희두 , 이지우 , 박형근 , 박옥희 , 이용실 , 박영호 , 주영협 , 최진규 , 임경민 , 김선영 , 김진관 , 고현주 , 모주현 , 정연수 , 이정범 , 오영임
IPC: A61K31/17 , C07C335/04
CPC classification number: C07D333/42 , C07C311/08 , C07C311/47 , C07C333/20 , C07C335/12 , C07C335/14 , C07C335/20 , C07C335/26 , C07C2601/14 , C07C2602/10 , C07D207/323 , C07D207/416 , C07D207/42 , C07D209/08 , C07D209/14 , C07D213/40 , C07D213/61 , C07D213/76 , C07D217/06 , C07D231/14 , C07D231/56 , C07D233/64 , C07D235/14 , C07D239/42 , C07D241/12 , C07D241/24 , C07D277/28 , C07D295/13 , C07D295/215 , C07D295/32 , C07D307/52 , C07D311/58 , C07D317/58 , C07D333/20
Abstract: 본 발명은 바닐로이드 수용체(Vanilloid Receptor; VR)에 대한 조절제로서 신규한 티오우레아 유도체 및 이를 함유하는 약제학적 조성물에 관한 것이다.
바닐로이드 수용체의 활성과 연관된 질환에는 통증, 급성 통증, 만성 통증, 신경병적 통증, 수술후 통증, 편두통, 관절통, 신경병증, 신경손상, 당뇨병성 신경병, 신경변성 질환, 신경성 피부질환, 뇌졸중, 방광과민증, 과민성 장증후군, 천식과 만성폐색성 폐질환등 호흡기 이상, 피부, 눈, 점막의 자극, 발열, 위-십이지장궤양, 염증성 장 질환 및 염증성 질환 등이 포함될 수 있다. 본 발명은 이들 질환의 예방, 치료를 위한 약제학적 조성물을 제공한다.
바닐로이드 수용체, 티오우레아 유도체, 통증, 염증, 궤양-
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公开(公告)号：KR101932248B1
公开(公告)日：2018-12-21
申请号：KR1020110098052
申请日：2011-09-28
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 후보 물질을 처리한 피부 각질 세포에서 연장 효소(elongase)의 발현 정도를 확인하는 단계를 포함하는 아토피 피부염 개선용 물질 스크리닝 방법을 개시한다. 또한 본 발명은 피부의 연장 효소 발현 정도 분석부를 포함하는 아토피 피부염 진단 키트를 개시한다.
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