公开(公告)号：KR1020110000715A

公开(公告)日：2011-01-05

申请号：KR1020100117490

申请日：2010-11-24

Applicant: (주)아모레퍼시픽

Inventor： 박선미 ,  신동욱 ,  이상민 ,  송민정 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61K36/54 ,  A61Q19/00

Abstract: PURPOSE: A composition containing medicinal herb extract for skin care or plasty is provided to promote differentiation of mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for promoting adipocyte differentiation contains Linderae Radix extract as an active ingredient. The composition increases fat tissue and promotes differentiation of mesenchymal stem cells to adipocytes. The mesenchymal stem cells are derived from human bone marrow.

Abstract translation: 目的：提供含有用于护肤或整形的药草提取物的组合物，以促进间充质干细胞向脂肪细胞的分化。 构成：用于促进脂肪细胞分化的组合物含有紫草提取物作为活性成分。 组合物增加脂肪组织并促进间充质干细胞向脂肪细胞的分化。 间充质干细胞衍生自人骨髓。

公开(公告)号：KR1020100060752A

公开(公告)日：2010-06-07

申请号：KR1020080119483

申请日：2008-11-28

Applicant: (주)아모레퍼시픽

Inventor： 최현 ,  여현주 ,  노민수 ,  김한곤

IPC: C12Q1/68 ,  A61K36/58

CPC classification number: G01N33/5023 ,  A61K36/58 ,  C12Q1/6844 ,  C12Q2600/136 ,  G01N33/15

Abstract: PURPOSE: A method for screening a material which relieves skin irritation by environmental harmful factor is provided to manufacture an external use formulation and to detoxify. CONSTITUTION: A method for screening a material which relieves skin irritation by environmental harmful factor comprises: a step of treating candidates which regulates intracellular factor in vitro; a step of treating the environmental harmful factor to test cells to induce overexpression of the factor; and a step of measuring expression level. The test cells are keratinocytes. The environmental harmful factor is pollen or yellow sand. The overexpressed factor is interleukin 6 or 8, GSTT1, NQ01, or hBD3. The screened material is Melia azedarach L. var. japonica Makino or Tussilago farfara L. extract.

Abstract translation: 目的：提供一种用于筛选由环境有害因素减轻皮肤刺激的物质的方法，以制造外用制剂和解毒。 构成：通过环境有害因子筛选缓解皮肤刺激的材料的方法包括：处理体外调节细胞因子的候选物的步骤; 治疗环境有害因素以测试细胞以诱导因子过表达的步骤; 以及测量表达水平的步骤。 测试细胞是角质形成细胞。 环境有害因素是花粉或黄沙。 过表达因子是白细胞介素6或8，GSTT1，NQ01或hBD3。 筛选的材料是Melia azedarach L. var。 粳稻或东方龙草L.提取物。

公开(公告)号：KR1020100059042A

公开(公告)日：2010-06-04

申请号：KR1020080117680

申请日：2008-11-25

Applicant: (주)아모레퍼시픽 ,  고려대학교 산학협력단

Inventor： 최현 ,  여현주 ,  노민수 ,  신화영 ,  김한곤 ,  도성재 ,  김원년

IPC: A61K31/195 ,  C12Q1/68 ,  A61K31/352

CPC classification number: A61K31/195 ,  A61K31/352 ,  C12Q1/6844 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/15 ,  G01N33/5023

Abstract: PURPOSE: A method for screening a material which induces skin irritation by yellow dust is provided to reduce skin irritative factor expression and to reduce skin irritation by yellow dust. CONSTITUTION: A method for screening a material which induces skin irritation by yellow dust comprises: a step of treating yellow dust to keratinocytes; and a step of screening a gene of which expression level is significantly changed comparing with the expression of normal keratinocytes through RT-PCR. The material which induces skin irritation by yellow dust is AhR or CYP. A method for screening a material which relieves skin irritation by yellow dust comprises: a step of treating yellow dust to test cells to induce overexpression of an irritative factor; a step of treating a candidate material to the overexpressed cells; a step of measuring expression level of the irritative factor by RT-PCR. The material which relieves skin irritation by yellow dust is Trichosanthis semen. An external use skin composition for relieving skin irritation contains 0.001-1 weight% of Trichosanthis semen.

Abstract translation: 目的：提供一种筛选黄色粉尘引起皮肤刺激的材料的方法，以减少皮肤刺激因子的表达，并减少黄色粉尘的皮肤刺激。 构成：用于筛选黄色粉尘引起皮肤刺激的材料的方法包括：将黄色粉末处理成角质形成细胞的步骤; 与通过RT-PCR的正常角质化细胞的表达相比，筛选其表达水平显着变化的基因的步骤。 黄色粉尘引起皮肤刺激的物质是AhR或CYP。 用于筛选减轻黄色粉尘对皮肤刺激的材料的方法包括：处理黄色粉尘以测试细胞以诱导刺激性因子的过度表达的步骤; 将候选材料处理到过表达细胞的步骤; 通过RT-PCR测定刺激因子的表达水平的步骤。 减轻黄色粉尘的皮肤刺激性的物质是Trichosanthis精液。 用于缓解皮肤刺激的外用皮肤组合物含有0.001-1重量％的Trichosanthis精液。

公开(公告)号：KR1020100010916A

公开(公告)日：2010-02-02

申请号：KR1020090067159

申请日：2009-07-23

Applicant: 한국과학기술원 ,  (주)아모레퍼시픽

Inventor： 나용주 ,  노민수 ,  김한곤 ,  신현정 ,  김미나

IPC: C12Q1/68 ,  G01N33/50

CPC classification number: C12Q1/6883 ,  C12Q2600/158

Abstract: PURPOSE: A method for screening dynamic stimulation for improving skin function is provided to measure biochemical change against external stimulation and screen kind, form, size, intensity, and time of dynamic stimulation. CONSTITUTION: A method for screening dynamic stimulation for improving skin function comprises: a first step of performing repeatitive dynamic stimulation to skin; a second step of measuring biochemical change of skin by dynamic stimulation; and a third step of selecting useful dynamic stimulation based on biochemical change. The measurement is performed by measuring mRNA expression level of fibroblast-derived gene. In the third step, nerve growth factor, neurotrophin 3, TIMP 1, TrkA, TrkC, TGF alpha, TGF beta1, TGF beta2 or TGF beta3 gene is selected as dynamic stimulation.

Abstract translation: 目的：提供一种用于筛选动态刺激以改善皮肤功能的方法，以测量对外部刺激和屏幕种类，形态，大小，强度和动态刺激时间的生物化学变化。 构成：用于筛选动态刺激以改善皮肤功能的方法包括：对皮肤进行重复动态刺激的第一步骤; 通过动态刺激测量皮肤生化变化的第二步; 以及基于生物化学变化选择有用的动态刺激的第三步。 通过测量成纤维细胞衍生基因的mRNA表达水平进行测量。 在第三步中，选择神经生长因子，神经营养因子3，TIMP1，TrkA，TrkC，TGFα，TGFβ1，TGFβ2或TGFβ3基因作为动态刺激。

公开(公告)号：KR1020080050786A

公开(公告)日：2008-06-10

申请号：KR1020060121508

申请日：2006-12-04

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  김대권 ,  성기사 ,  김혁 ,  조선아 ,  김광미 ,  노민수 ,  이창훈 ,  김정주

IPC: A61K31/133

Abstract: A method for inducing itch and a method for screening an itch inhibiting material using glucosylsphingosine are provided to be useful for studying and understanding the itch, thereby being very usefully used for developing a therapeutic agent for the itch and evaluating the effect of a medicine. A method for inducing itch comprises a step of administering at least one compound selected from the group consisting of glucosylsphingosine and a derivative thereof into an animal except human. A method for screening an itch inhibiting material comprises the steps of: (a) administering an itch inhibition candidate material to an animal where the itch is induced by administering at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof; and (b) counting a number when the animal scratches. A method for evaluating the itch inhibition effect comprises the steps of: (a) administering an itch inhibition material to an animal where the itch is induced by administering at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof; and (b) counting a number when the animal scratches. A composition for inducing itch comprises at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof as an effective ingredient.

Abstract translation: 提供诱导瘙痒的方法和使用葡糖基鞘氨醇来筛选瘙痒抑制物质的方法，可用于研究和理解瘙痒，从而非常有用地用于开发瘙痒治疗剂并评估药物的效果。 诱导瘙痒的方法包括向除人之外的动物中施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物的步骤。 筛选瘙痒抑制物质的方法包括以下步骤：（a）通过施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物，向瘙痒诱导的动物施用瘙痒抑制候选物质; 和（b）当动物划伤时计数。 评估瘙痒抑制效果的方法包括以下步骤：（a）向通过施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物诱导瘙痒的动物施用瘙痒抑制物质; 和（b）当动物划伤时计数。 用于诱导瘙痒的组合物包含至少一种选自葡糖基鞘氨醇及其衍生物的化合物作为有效成分。

公开(公告)号：KR102083438B1

公开(公告)日：2020-03-03

申请号：KR1020110114689

申请日：2011-11-04

Applicant: (주)아모레퍼시픽 ,  동국대학교 산학협력단

Inventor： 이애영 ,  노민수 ,  이태룡 ,  최현정

IPC: C12N15/63 ,  C12N15/861 ,  C12Q1/68 ,  G01N33/53

公开(公告)号：KR101904918B1

公开(公告)日：2018-10-08

申请号：KR1020110116647

申请日：2011-11-09

Applicant: (주)아모레퍼시픽

Inventor： 최현정 ,  최현 ,  한지연 ,  박주열 ,  신동욱 ,  이태룡 ,  노민수 ,  김광미

IPC: G01N33/68 ,  G01N33/15

Abstract: 본발명은피부색소침착조절물질을스크리닝하는방법에관한것이다. 본명세서에기재된기술을이용하면, 피부에유용한피부색소침착조절용물질을스크리닝할수 있다. 또한, 본발명의세포간, 세포내 신호전달인자및 전사인자를조절함으로써, 피부멜라닌양의감소또는증가에의하여발생하는저색소증또는과색소침착증등의질환을효과적으로개선할수 있다. 즉, 자외선에의한피부흑화뿐만아니라, 아토피나건선에의한 2차적인피부저색소증및 색소이상증, 피부염증이관여한다고알려져있는기미, 점(nevi), 흑자, 검버섯과같은피부과색소침착증, 백반증또는백모와같은색소결여증에유용한물질을스크리닝할수 있고그 스크리닝된 물질을사용하여상기증상들을개선, 치료할수 있다.

公开(公告)号：KR101784998B1

公开(公告)日：2017-10-16

申请号：KR1020100120142

申请日：2010-11-30

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  김윤경 ,  이명렬 ,  이종석 ,  박창훈 ,  이태룡 ,  김한곤 ,  노민수 ,  신동욱

IPC: C12Q1/68 ,  A61Q17/04

Abstract: 본발명은선스크린효능을평가하는방법에관한것으로, 보다상세하게는피부세포에서특정유전자발현을통해자외선뿐만아니라피부손상을가장많이유도하는 400∼500 nm 영역의블루/바이올렛라이트차단효능을함께평가함으로써보다정확하고높은신뢰도로선스크린효능을평가하는방법에관한것이다.

Abstract translation: 更具体地说，本发明涉及一种用于评估400-500nm范围内的蓝/紫光的功效的方法，其通过表达特定基因不仅诱导紫外线，而且还诱导皮肤细胞中最多的皮肤损伤。 更准确可靠地评估屏幕效能。

公开(公告)号：KR101601020B1

公开(公告)日：2016-03-09

申请号：KR1020080114594

申请日：2008-11-18

Applicant: (주)아모레퍼시픽

Inventor： 박준성 ,  박혜윤 ,  김동현 ,  이상민 ,  신동욱 ,  김신형 ,  노민수 ,  김덕희 ,  김한곤

IPC: A61K31/366 ,  A61K31/352 ,  A61P17/00

CPC classification number: A61K31/352 ,  A61K9/0014 ,  A61K31/366

Abstract: 본발명은오르토-디하이드록시이소플라본유도체를유효성분으로함유하는표피과증식억제용및 염증성피부질환개선용피부외용제조성물에관한것으로, 보다상세하게는오르토-디하이드록시이소플라본유도체인 4',6,7-트리하이드록시이소플라본, 3',4',7-트리하이드록시이소플라본또는이들의혼합물을함유함으로써 Wnt 신호전달을적절하게제어하는 DKK3 단백질및 FZD1단백질의발현을향상시켜표피의과도한증식을억제하고, 표피의과증식으로인한염증성피부질환을개선하는표피과증식억제용및 염증성피부질환개선용피부외용제조성물에관한것이다.

公开(公告)号：KR1020150135757A

公开(公告)日：2015-12-03

申请号：KR1020150162789

申请日：2015-11-19

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  송민정 ,  노민수 ,  이형호 ,  이상민 ,  양승하 ,  김한곤

IPC: A61K8/97 ,  A61K36/898 ,  A61Q19/00

Abstract: 본발명은인간중간엽줄기세포의지방세포로의분화를촉진하는조성물에관한것으로, 보다상세하게는건율, 권백, 노회, 단삼, 박하, 반하, 소맥, 어성초, 원지및 조각인추출물중 1종이상을유효성분으로함유하여인간중간엽줄기세포를지방세포로분화하는것을촉진시킴으로써지방체(Lipid droplet)를생성하여, 특정부위의피부의볼륨감을증대시키는미용또는성형용조성물에관한것이다.

Abstract translation: 本发明涉及促进人类间充质干细胞分化为脂肪细胞的组合物，更具体地说，涉及一种美容或美容手术的组合物，其通过包括一种或多种促进人间充质干细胞分化成脂肪细胞， 作为活性成分，在干栗子，卷柏卷心菜，芦荟L.，丹参，薄荷提取物中。 胡椒碱，​​苦参，白芷，小麦，鱼腥草，Polygala tenuifolia Willdenow和Gleditsia sinensis Lam，从而产生脂滴，从而增加特定区域的皮肤体积。